Cognitive Thalamus

认知丘脑

• 批准号: 10633804
• 负责人: SABINE KASTNER
• 金额: $ 326.69万
• 依托单位: PRINCETON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-03 至 2028-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10633804
• 关键词: Anatomy; Animal Model; Animals; Area; Attention; Basal Ganglia; Behavior; Behavioral; Brain; Brain Diseases; Brain imaging; Cell Nucleus; Cells; Cerebral cortex; Cognition; Cognitive; Communication; Communities; Complement; Computer Models; Computing Methodologies; Data; Data Collection; Decision Making; Diagnosis; Disease; Disease model; Dissection; Dorsal; Education and Outreach; Electrodes; Electrophysiology (science); Elements; Etiology; Glues; Goals; Human; Image; Impaired cognition; Impairment; Link; Macaca; Macaca mulatta; Maps; Medial Dorsal Nucleus; Memory; Methods; Modeling; Neurons; Office of Administrative Management; Optics; Output; Parietal Lobe; Patients; Perception; Performance; Play; Positioning Attribute; Primates; Property; Prosencephalon; Pulvinar structure; Regulation; Research Personnel; Role; Route; Schizophrenia; Seminal; Sensory Process; Shapes; Stimulus; Stream; Structure; Symptoms; Thalamic Nuclei; Thalamic structure; Therapeutic Intervention; Training Activity; Translating; Tupaia; Tupaiidae; Visual Cortex; Visual System; Visual attention; cognitive control; cognitive process; data sharing; executive function; extrastriate visual cortex; frontal lobe; human disease; imaging study; insight; multimodality; neglect; neural; neural circuit; neuroimaging; nonhuman primate; optogenetics; response; theories; transmission process

PROJECT SUMMARY The Pulvinar (PUL) and Mediodorsal (MD) nuclei are higher order thalamic structures that are known to play critical roles in various cognitive domains. However, the precise mechanisms are unknown, with theories suggesting their role in either gating or facilitating functional connectivity across their cortical targets. Imoprtantly, recent evidence from schizophrenia patients suggests that these higher order thalamic-cortical interactions are perturbed and may even be causative to disease etiology. In this Center, we have assembled a group of investigators who will utilize behavior, electrophysiology, imaging in human and non-human animals to 1. Identify cognitive functional organization principles of higher-order thalamic nuclei in interacting with cortex; 2. Translate thalamic functionality from animal models to the healthy and diseased human brain; and 3. Develop a biologically plausible model for the human higher-order thalamus. The Center will be divided into 5 Scientific Projects and 3 Cores. Project 1 (PI Usrey) will combine electrophysiology and optical perturbations to study interactions between PUL and early visual cortical areas during attentional processing. Project 2 (PI Kastner) will take a large-scale network approach in the macaque to study interactions between the primate-specific mdPUL subdivision and fronto-parietal networks in attention, and also study interactions between the MD and frontal cortical areas in hierarchical reasoning and task switching. Project 3 (PI Halassa) will combine optical perturbations, electrophysiology and disease modeling in Tupaia to study interactions between PUL regulation of dorsal vs. ventral stream selection in attention, and MD regulation of frontal cortical interactions in hierarchical reasoning. Project 4 (PI Collins/Arcaro) will combine functional neuroimaging and behavior in humans to interrogate PUL and MD engagement with their cortical partners in attention and hierarchical reasoning, respectively. This will begin an exciting endeavor of determining what types of higher order thalamic contributions to cognition have expanded in the human brain. Project 5 (PI Woodward) will examine behavior-brain relationships (attention-PUL and decision making-MD) in schizophrenia patients, where the structural integrity of higher order thalamic connectivity to cortical partners is known to be impaired. Core A (PIs Kastner, Halassa and Usrey) will administratively manage this Center and involve important outreach and training activities. Core B (PI Chen) will provide analytical support for all projects and streamline data collection, curation and sharing across PIs with common format, as well as allow for data sharing with the broader community. Core C (PI Kopell) will generate computational models that will be iteratively refined by the collected data and provide testable prediction on an ongoing basis. Altogether, successful launching of this Center promises to provide new frameworks for the neural circuitry underlying cognitive processing and how the thalamus may be a target for enhancing cognition in schizophrenia.

项目摘要 pulvinar（pul）和中型核（MD）核是已知可以发挥的高阶丘脑结构 在各种认知领域的关键作用。但是，精确的机制是未知的，有理论 表明它们在跨皮质靶标的门控或促进功能连通性中的作用。 不可避免的是，精神分裂症患者的最新证据表明这些高阶丘脑皮层 相互作用受到干扰，甚至可能是疾病病因的原因。在这个中心，我们已经组装了 一组研究人员将利用人类和非人类的行为，电生理学，成像 动物至1。确定相互作用的高阶丘脑核的认知功能组织原理 与皮质； 2。将丘脑功能从动物模型转换为健康和患病的人脑； 和3。为人类高阶丘脑开发一个生物学上合理的模型。中心将分开 进入5个科学项目和3个核心。项目1（Pi Usrey）将结合电生理学和光学 注意力处理过程中PUL和早期视觉皮质区域之间的相互作用的扰动。 项目2（Pi Kastner）将采用猕猴的大规模网络方法来研究 引起人们注意的灵长类动物特异性MDPUL细分和额叶网络，还研究了相互作用 在层次推理和任务切换中的MD和额叶皮质区域之间。项目3（pi halassa） 将结合图帕的光学扰动，电生理学和疾病建模来研究相互作用 在注意力中的脉冲调节与腹侧的脉冲调节之间，以及额叶皮质的MD调节 分层推理中的相互作用。项目4（PI Collins/Arcaro）将结合功能性神经影像学和 人类的行为以询问PUL和MD与皮质伴侣的互动和MD的关注和 分别分别推理。这将开始一项令人兴奋的努力，以确定哪种类型的更高类型 丘脑对认知的秩序贡献在人脑中已扩大。项目5（Pi Woodward）将 检查精神分裂症患者中的行为 - 脑关系（注意力-PUL和决策-MD）， 高阶丘脑连通性与皮质伴侣的结构完整性受到损害。 核心A（PIS Kastner，Halassa和Usrey）将在行政上管理这个中心，并涉及重要 推广和培训活动。 Core B（Pi Chen）将为所有项目提供分析支持 跨PI的数据收集，策划和共享以通用格式，并允许与数据共享 更广泛的社区。 Core C（Pi Kopell）将生成将迭代精制的计算模型 通过收集的数据，并持续提供可测试的预测。总共成功启动 该中心有望为基础认知处理的神经电路提供新的框架 以及丘脑如何成为增强精神分裂症认知的目标。