Data and Analytical Core

丘脑在注意力、认知控制和决策中起着关键作用， 大规模大脑皮层节点间时间整合和协调的重要枢纽 和皮质下网络。丘脑皮质功能连接性的鉴定 跨任务和物种的网络是理解复杂的丘脑计算的关键 无论是单一单位水平还是人口水平。Conte Center项目的数据和分析核心 将在多个方向上为实现中心的目标作出贡献。我们将建立一个数据 管理/共享渠道并开发高级统计和数据驱动的机器学习 用于分析来自高阶丘脑核团的各种神经记录来源的工具 (尤其是丘脑和枕部的内侧)在非人和人类灵长类动物中。在……里面 目标1，我们将建立一个半自动的人在环路管道，用于数据管理， 文档和共享。在目标2中，我们将开发多变量数据分析工具包 开放获取软件和文档。在目标3中，我们将开发集成工具来测试 丘脑高级核团在调节丘脑-皮质功能连接中的作用。这个 Data and Analytic Core将与其他项目PI协作，并为 动物和人类电生理的数据共享、分析和工具开发 神经成像数据。这些目标的实现将促进我们对丘脑- 健康和患病大脑中的皮质通讯。

The thalamus plays a critical role in attention, cognitive control and decision-making, serving as an important hub of temporal integration and coordination across nodes of large-scale cortical and subcortical networks. Identification of functional connectivity between thalamocortical networks across tasks and species is key to understanding complex thalamic computation at both single-unit and population levels. The Data and Analytic Core of the Conte Center project will contribute to attaining the Center objectives in multiple directions. We will establish a data curation/sharing pipeline and develop advanced statistical and data-driven machine learning tools for analyses of various sources of neural recordings from higher-order thalamic nuclei (especially the mediodorsal thalamus and pulvinar) in both nonhuman and human primates. In Aim 1, we will establish a semi-automated human-in-the-loop pipeline for data curation, documentation, and sharing. In Aim 2, we will develop multivariate data analysis toolkits with open-access software and documentation. In Aim 3, we will develop integrated tools to test the role of higher order thalamic nuclei in regulating thalamo-cortical functional connectivity. The Data and Analytic Core will collaborate with other project PIs and provide strong support for data sharing, analysis and tool development for both animals’ electrophysiological and humans’ neuroimaging data. Accomplishment of these aims will advance our understanding of thalamo- cortical communications in healthy and diseased brains.