Data and Analytical Core

数据和分析核心

• 批准号: 10633812
• 负责人: Zhe Sage Chen
• 金额: $ 34.7万
• 依托单位: PRINCETON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-03 至 2028-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10633812
• 关键词: Animals; Attention; Behavioral; Brain; Brain Diseases; Brain region; Cognition; Cognitive; Collaborations; Communication; Communities; Complex; Computer Models; Computer software; Data; Data Analyses; Data Analytics; Data Set; Decision Making; Dedications; Documentation; Electrophysiology (science); Functional Magnetic Resonance Imaging; Glues; Human; Image; Individual; Lead; Link; Machine Learning; Methods; Modeling; Monkeys; Multivariate Analysis; National Institute of Mental Health; Neurons; Neurosciences; Play; Population; Postdoctoral Fellow; Primates; Process; Publications; Pulvinar structure; Pythons; Recording of previous events; Reporting; Reproducibility; Research; Research Personnel; Research Project Grants; Resource Sharing; Resources; Rodent; Role; Source; Structure; Techniques; Testing; Thalamic Nuclei; Thalamic structure; Travel; Tupaiidae; analytical tool; attentional control; cognitive control; data archive; data curation; data format; data pipeline; data sharing; executive function; high standard; human imaging; human-in-the-loop; innovation; machine learning method; meetings; multimodal data; multimodality; neural; neuroimaging; neuroregulation; statistical and machine learning; statistics; theories; tool; tool development; virtual; web site

The thalamus plays a critical role in attention, cognitive control and decision-making, serving as an important hub of temporal integration and coordination across nodes of large-scale cortical and subcortical networks. Identification of functional connectivity between thalamocortical networks across tasks and species is key to understanding complex thalamic computation at both single-unit and population levels. The Data and Analytic Core of the Conte Center project will contribute to attaining the Center objectives in multiple directions. We will establish a data curation/sharing pipeline and develop advanced statistical and data-driven machine learning tools for analyses of various sources of neural recordings from higher-order thalamic nuclei (especially the mediodorsal thalamus and pulvinar) in both nonhuman and human primates. In Aim 1, we will establish a semi-automated human-in-the-loop pipeline for data curation, documentation, and sharing. In Aim 2, we will develop multivariate data analysis toolkits with open-access software and documentation. In Aim 3, we will develop integrated tools to test the role of higher order thalamic nuclei in regulating thalamo-cortical functional connectivity. The Data and Analytic Core will collaborate with other project PIs and provide strong support for data sharing, analysis and tool development for both animals’ electrophysiological and humans’ neuroimaging data. Accomplishment of these aims will advance our understanding of thalamo- cortical communications in healthy and diseased brains.

丘脑在注意力、认知控制和决策方面起着关键作用， 大规模皮层神经元节点间时间整合和协调的重要枢纽 和皮层下网络。丘脑-皮质功能连接的鉴定 跨任务和物种的网络是理解复杂的丘脑计算的关键， 单位和人口水平。Conte Center项目的数据和分析核心 将有助于在多个方向实现中心的目标。我们会建立一个数据库 策展/共享管道，并开发先进的统计和数据驱动的机器学习 用于分析来自高级丘脑核团的各种神经记录源的工具 （尤其是中背丘脑和枕）在非人类和人类灵长类动物。在 目标1，我们将建立一个半自动化的人在回路管道进行数据管理， 文档和共享。在目标2中，我们将开发多变量数据分析工具包， 开放获取软件和文档。在目标3中，我们将开发集成工具来测试 丘脑高级核团在调节丘脑-皮质功能连接中的作用。的 数据和分析核心将与其他项目PI合作，并为以下方面提供强有力的支持 为动物的电生理和人类的数据共享、分析和工具开发 神经成像数据。这些目标的实现将促进我们对thalamo的理解- 健康和患病大脑中的皮层通讯。