Data and Analytical Core
Data and Analytical Core
批准号:
10633812
负责人:
Zhe Sage Chen
金额:
$34.7万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2023
资助国家:
美国
项目状态:
未结题
起止时间:
2023-04-03 至 2028-03-31
关键词:
AnimalsAttentionBehavioralBrainBrain DiseasesBrain regionCognitionCognitiveCollaborationsCommunicationCommunitiesComplexComputer ModelsComputer softwareDataData AnalysesData AnalyticsData SetDecision MakingDedicationsDocumentationElectrophysiology (science)Functional Magnetic Resonance ImagingGluesHumanImageIndividualLeadLinkMachine LearningMethodsModelingMonkeysMultivariate AnalysisNational Institute of Mental HealthNeuronsNeurosciencesPlayPopulationPostdoctoral FellowPrimatesProcessPublicationsPulvinar structurePythonsRecording of previous eventsReportingReproducibilityResearchResearch PersonnelResearch Project GrantsResource SharingResourcesRodentRoleSourceStructureTechniquesTestingThalamic NucleiThalamic structureTravelTupaiidaeanalytical toolattentional controlcognitive controldata archivedata curationdata formatdata pipelinedata sharingexecutive functionhigh standardhuman imaginghuman-in-the-loopinnovationmachine learning methodmeetingsmultimodal datamultimodalityneuralneuroimagingneuroregulationstatistical and machine learningstatisticstheoriestooltool developmentvirtualweb site
中文摘要
丘脑在注意力、认知控制和决策中起着关键作用,
大规模大脑皮层节点间时间整合和协调的重要枢纽
和皮质下网络。丘脑皮质功能连接性的鉴定
跨任务和物种的网络是理解复杂的丘脑计算的关键
无论是单一单位水平还是人口水平。Conte Center项目的数据和分析核心
将在多个方向上为实现中心的目标作出贡献。我们将建立一个数据
管理/共享渠道并开发高级统计和数据驱动的机器学习
用于分析来自高阶丘脑核团的各种神经记录来源的工具
(尤其是丘脑和枕部的内侧)在非人和人类灵长类动物中。在……里面
目标1,我们将建立一个半自动的人在环路管道,用于数据管理,
文档和共享。在目标2中,我们将开发多变量数据分析工具包
开放获取软件和文档。在目标3中,我们将开发集成工具来测试
丘脑高级核团在调节丘脑-皮质功能连接中的作用。这个
Data and Analytic Core将与其他项目PI协作,并为
动物和人类电生理的数据共享、分析和工具开发
神经成像数据。这些目标的实现将促进我们对丘脑-
健康和患病大脑中的皮质通讯。
英文摘要
The thalamus plays a critical role in attention, cognitive control and decision-making, serving as
an important hub of temporal integration and coordination across nodes of large-scale cortical
and subcortical networks. Identification of functional connectivity between thalamocortical
networks across tasks and species is key to understanding complex thalamic computation at
both single-unit and population levels. The Data and Analytic Core of the Conte Center project
will contribute to attaining the Center objectives in multiple directions. We will establish a data
curation/sharing pipeline and develop advanced statistical and data-driven machine learning
tools for analyses of various sources of neural recordings from higher-order thalamic nuclei
(especially the mediodorsal thalamus and pulvinar) in both nonhuman and human primates. In
Aim 1, we will establish a semi-automated human-in-the-loop pipeline for data curation,
documentation, and sharing. In Aim 2, we will develop multivariate data analysis toolkits with
open-access software and documentation. In Aim 3, we will develop integrated tools to test the
role of higher order thalamic nuclei in regulating thalamo-cortical functional connectivity. The
Data and Analytic Core will collaborate with other project PIs and provide strong support for
data sharing, analysis and tool development for both animals’ electrophysiological and humans’
neuroimaging data. Accomplishment of these aims will advance our understanding of thalamo-
cortical communications in healthy and diseased brains.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Predictive Biosignature for Endoscopic Therapy for Chronic Pancreatitis Pain
-
批准号:10794609
-
项目类别:
-
资助金额:$124.48万
-
财政年份:2023
-
负责人:Zhe Sage Chen
-
依托单位:
Cortical information integration as a model for pain perception and behavior
-
批准号:10205303
-
项目类别:
-
资助金额:$197.82万
-
财政年份:2021
-
负责人:Zhe Sage Chen
-
依托单位:
CRNS: An Integrative Study of Hippocampal-Neocortical Memory Coding during Sleep
-
批准号:10401807
-
项目类别:
-
资助金额:$33.68万
-
财政年份:2018
-
负责人:Zhe Sage Chen
-
依托单位:
CRNS: An Integrative Study of Hippocampal-Neocortical Memory Coding during Sleep
-
批准号:9920779
-
项目类别:
-
资助金额:$35.85万
-
财政年份:2018
-
负责人:Zhe Sage Chen
-
依托单位:
CRCN: Dissecting Neural Circuits for Acute Pain
-
批准号:9313960
-
项目类别:
-
资助金额:$37.08万
-
财政年份:2016
-
负责人:Zhe Sage Chen
-
依托单位:
CRCN: Dissecting Neural Circuits for Acute Pain
-
批准号:9242180
-
项目类别:
-
资助金额:$37.08万
-
财政年份:2016
-
负责人:Zhe Sage Chen
-
依托单位:
国内基金
海外基金
多模态超声VisTran-Attention网络评估早期子宫颈癌保留生育功能手术可行性
-
批准号:--
-
项目类别:青年科学基金项目
-
资助金额:30万元
-
批准年份:2022
-
负责人:郑巧
-
依托单位:
Ultrasomics-Attention孪生网络早期精准评估肝内胆管癌免疫治疗的研究
-
批准号:--
-
项目类别:面上项目
-
资助金额:52万元
-
批准年份:2022
-
负责人:陈立达
-
依托单位: