HD2A RASC-SUD Implementation Support Core

这项研究是NIH帮助结束成瘾长期(Hear)倡议的一部分，该倡议旨在加快科学解决国家阿片类药物公共健康危机的速度。NIH Hear Initiative支持整个NIH的研究，以改善阿片类药物滥用和成瘾的治疗，并制定能够为阿片类药物危机提供快速和持久解决方案的具体战略。SUD实施支持核心：项目摘要/摘要尽管联邦政府在开发和传播针对物质使用障碍(SUDS)的循证药理学和行为干预措施方面进行了大量投资，但药物过量死亡人数仍在继续上升。由于将研究知识和以证据为基础的SUD干预措施转化为公共卫生实践的挑战，对过量用药死亡的指导努力已经停滞不前。可悲的是，在整个美国医疗保健系统中，获得循证SUD干预措施的机会仍然非常有限，特别是对于黑人/非裔美国人、夏威夷原住民/太平洋岛民、亚裔美国人和未参保的历史边缘人群。公平地将研究成果转化为实践是传播和实施(D&I)科学的领域。作为HD2A研究采用支持中心(RASC)的核心组成部分，SUD实施支持(SUD-IS)核心将为创新项目带来最好的研发科学，以指导选择、实施和维持以证据为基础的、当地适当的SUD干预措施，以降低重灾区的过量用药风险。核心领导层将通过利用尖端的D&I措施和方法，并利用我们团队对团队科学的承诺，将实施科学家和SUD研究人员统一起来-近期目标是增强创新项目的影响，最终目标是改善公共健康。在主题和操作上，与RASC和其他核心一起，SUD-IS核心将通过评估、协助和推进的动态和迭代阶段来提升创新项目。我们将首先评估SUD干预措施的证据现状，以便：a)制定基于证据的和新出现的做法的系统目录；以及b)根据五个关键的D&I结构(例如，背景决定因素、干预的证据支持、利益相关者参与、实施战略和实施结果，包括公平和耻辱)，为创新项目和任何SUD干预实施项目制定一份SUD干预D&I资源指南。然后，我们将利用评估阶段收集的信息协助创新项目，以便：a)增强动力，利用利用核心专业知识的量身定制的D&I方法来加强其研究；b)提供D&I实施支持计划，并使用共享的决策方法来确定如何最好地提供技术援助；以及c)共同领导RASC学习协作。最后，我们将推进创新项目在可持续、公平和减少污名方面的活动：将项目与整个领域联系起来，促进对政策/融资的影响，并促进利益攸关方持续参与宣传。与RASC完全一致，我们共同朝着弥合长期和不公平的差距迈出了重要的一步，获得经过验证的SUD药物和心理社会治疗的机会。

This study is part of the NIH’s Helping to End Addiction Long-term (HEAL) initiative to speed scientific solutions to the national opioid public health crisis. The NIH HEAL Initiative bolsters research across NIH to improve treatment for opioid misuse and addiction and to develop concrete strategies capable of providing rapid and durable solutions to the opioid crisis. SUD IMPLEMENTATION SUPPORT CORE: PROJECT SUMMARY/ABSTRACT Drug overdose fatalities have continued to rise despite massive federal investment in developing and disseminating evidence-based pharmacological and behavioral interventions for substance use disorders (SUDs). Attempts to move the needle on overdose deaths have stalled because of challenges translating research knowledge and evidence-based SUD interventions into public health practice. Access to evidence- based SUD interventions remains woefully limited throughout the U.S. health care system, particularly for historically marginalized populations such as Black/African-Americans, Native Hawaiians/Pacific Islanders, Asian Americans, and the uninsured. Equitable translation of research findings into practice is the domain of dissemination and implementation (D&I) science. A core component of the HD2A Research Adoption Support Center (RASC), the SUD Implementation Support (SUD-IS) Core will bring the best of D&I science to the Innovation Projects to guide the selection, implementation, and sustainment of evidence-based, locally appropriate SUD interventions to reduce overdose risk in hard hit communities. Core leadership will unify implementation scientists and SUD researchers - with the proximal goal of enhancing the impact of the Innovation Projects and the ultimate goal of improving public health - by leveraging cutting-edge D&I measures and methods, and capitalizing on our team’s commitment to team science. Thematically and operationally in tandem with the RASC and other cores, the SUD-IS Core will elevate the Innovation Projects through dynamic and iterative phases of ASSESS, ASSIST, and ADVANCE. We will first ASSESS the current state of evidence for SUD interventions in order to: a) develop a systematic catalog of evidence-based and emerging practices; and b) develop an SUD Intervention D&I Resource Guide for the Innovation Projects and any SUD intervention implementation project based on five key D&I constructs (e.g., contextual determinants, evidentiary support for the intervention, stakeholder engagement, implementation strategies, and implementation outcomes including equity and stigma). We will then ASSIST the Innovation Projects using information gathered in the ASSESS phase in order to: a) enhance motivation to enhance their studies with tailored D&I approaches that draw upon Core expertise; b) provide a D&I Implementation Support Plan and use a shared decision-making approach to determine how best to offer technical assistance; and c) co-lead the RASC Learning Collaborative. Finally, we will ADVANCE the Innovation Projects’ activities with respect to sustainment, equity, and stigma reduction: linking projects with the field at large, promoting impacts on policy/financing and facilitating ongoing stakeholder engagement towards advocacy. Perfectly aligned with the RASC, together we take a major step toward closing the persistent and inequitable gap of access to proven pharmacologic and psychosocial treatments for SUD.