Decision Support Training for Advanced Cancer Family Caregivers: The CASCADE Factorial Trial

晚期癌症家庭护理人员的决策支持培训：CASCADE 析因试验

• 批准号: 10633116
• 负责人: James N. Dionne-Odom
• 金额: $ 52.44万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-15 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10633116
• 关键词: 2 arm randomized control trial; Address; Adult; Advance Directives; Advanced Malignant Neoplasm; Anxiety; Appointment; Cancer Family; Cancer Patient; Caregiver support; Caregivers; Caring; Clinical; Communication; Comprehensive Cancer Center; Conflict (Psychology); Consumption; Decision Making; Diagnosis; Distress; Effectiveness; Family; Family Caregiver; Friends; Health; Healthcare; Hospice Care; Hospitals; Interdisciplinary Study; Intervention; Location; Malignant Neoplasms; Measures; Mediator; Mental Depression; Methodology; NCI-Designated Cancer Center; Newly Diagnosed; Oncology; Operative Surgical Procedures; Outcome; Palliative Care; Patients; Persons; Process; Professional Practice; Quality of life; Randomized; Reporting; Reproducibility; Research; Research Design; Research Methodology; Self Efficacy; Social support; Testing; Time; Training; Training Support; Underrepresented Populations; cancer therapy; caregiver interventions; caregiving; cost; cost effective; end of life; experience; health care service utilization; improved; innovation; multiphase optimization strategy; novel; pilot test; preference; primary outcome; psychoeducation; psychoeducational; recruit; response; secondary outcome; skills; sociodemographics; telehealth; theories; therapy design

Project Summary/Abstract A priority in oncology and palliative care is preparing the 3.2 million U.S. family caregivers of persons with cancer to effectively support patients in health-related decision-making from diagnosis to the end of life, particularly in underserved settings. Over 70% of patients with cancer involve family in health decisions, including choices about treatments, surgery, location of care, accessing palliative care, and many others. Patients making these decisions with unprepared family caregivers may experience inadequate family decision support leading to heightened distress and receipt of care/treatments inconsistent with their values and preferences. This in turn may increase distress for family caregivers. There is a critical need to train cancer family caregivers to effectively support patient decision-making; however, few palliative care interventions have been tested to enhance caregiver skills in providing decision support. We have developed CASCADE (CAre Supporters Coached to be Adept DEcision partners), a lay navigator-led, telehealth early palliative care intervention to train advanced cancer caregivers how to effectively partner with patients in health decision- making. Evolving out of our prior early palliative care caregiving interventions, decision support relevant content for family caregivers includes principles of effective social support, communication, and Ottawa Decision Guide training; however we do not know which of these components and component interactions influences patient and caregiver decision-making outcomes. Traditional research approaches treat interventions as “bundled” treatment packages, making it difficult to assess definitively which intervention components can be reduced, eliminated, or replaced to improve efficiency. Hence, we propose a randomized 23 (2x2x2) factorial trial, the first such trial in oncology palliative care, using the Multiphase Optimization Strategy (MOST) to test components of CASCADE in order to assemble an optimized, scalable version of the intervention. 352 family caregivers of persons with newly-diagnosed advanced cancer will be randomized to receive one or more palliative care lay navigator-delivered decision partnering training components, based on the Ottawa Decision Support Framework and Social Support Effectiveness Theory: 1) psychoeducation on social support effectiveness in decision support (1 vs. 3 sessions); 2) decision support communication training (yes vs. no); and 3) Ottawa Decision Guide training (yes vs. no). We will determine CASCADE components (main effects/interactions) that contribute meaningfully to patient and caregiver outcomes, including patient healthcare utilization (Aim 1) and use those results to build a version of the CASCADE intervention that is maximally effective and scalable (Aim 2). To maximize recruitment, we will recruit from two NCI-designated comprehensive cancer centers in Birmingham, AL and Atlanta, GA. Using the innovative MOST framework will yield a highly novel and cost effective version of CASCADE primed for confirmatory RCT testing, scalability, and reproducibility.

项目总结/文摘