Physician Scientist Training in Cancer Research

癌症研究医师科学家培训

• 批准号: 10668481
• 负责人: Jennifer R Brown
• 金额: $ 53.9万
• 依托单位: DANA-FARBER CANCER INST
• 依托单位国家: 美国
• 财政年份: 1978
• 资助国家: 美国
• 起止时间: 1978-07-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10668481
• 关键词: Physicians; Scientist; Training; anticancer research

Summary With this competitive renewal application, we are seeking five years of support for a Training Program with the new Title of “Physician Scientist Training in Cancer Research” that has been continually funded since 1975. Since that time, more than 600 physicians and physician-scientists who were part of fellowship training programs in medical oncology received, through this funding mechanism, the essential support and protected time that they required to launch an academic career. Of the 117 trainees who have been supported by this T32 Award during the past 15 years, 13 continue as post-doctoral fellows in training. Of the remaining 104, 10 have left academia to pursue leadership positions in industry focused on cancer medicine, 6 are clinicians at major medical centers, 2 hold positions at the National Cancer Institute, and the remaining 86 are in academic positions including 2 Professors, 22 Associate Professors, 39 Assistant Professors, and 23 Instructors. Excluding fellows still in training, 90 former trainees of the remaining 104 have received external funding for their research including 37 that have been awarded an individual NIH K-type award. With the present application, we seek to continue this tradition of training the leaders in academic oncology. The future of cancer research will continue to depend on the continued training of highly-talented and creative physician-scientists who possess an understanding of the clinical aspects of neoplastic disease, are able to apply these concepts to appropriate laboratory studies within the many areas of tumor biology and emerge as academic leaders with sufficient skills to direct research programs, patient care, and educational efforts. The development of such individuals can only be accomplished within an environment where physicians and scientists work in physically adjacent areas, exchanging ideas and collaborating on a wide array of endeavors. The program will build on a foundation of excellence in Medical Oncology established during clinical training in the Dana-Farber/Massachusetts General Brigham Medical Oncology Fellowship Program. All of these candidates have already received an MD or MD/PhD degree, completed 2 or 3 years of Internal Medicine residency, and at least one year of clinical training in Medical Oncology. The training grant program will select the most highly qualified candidates from this pool who wish to pursue laboratory research or clinical investigation at the Dana-Farber Cancer Institute or nearby surrounding institutions. The program will provide outstanding mentored laboratory and clinical investigation research experiences from senior and experienced junior faculty and support for the recruitment and mentorship of under-represented minority fellows. It is expected that at the conclusion of their training, those individuals supported by this training program will have the ability to design, initiate, and complete individual clinical or laboratory research projects, will be able to function independently or with minimal supervision, and will be positioned to soon establish themselves as independent research investigators.

摘要 通过此竞争性续订申请，我们正在寻求对以下培训计划的五年支持 “癌症研究中的内科科学家培训”的新称号 1975年。从那时起，参加团契培训的600多名医生和内科科学家 通过这一资助机制，内科肿瘤学项目得到了必要的支持和保护 他们开始学术生涯所需的时间。在获得该基金资助的117名学员中 T32奖在过去的15年里，有13人继续作为博士后研究员参加培训。在剩下的104人中，有10人 离开学术界，转而追求专注于癌症药物的行业领导职位，6人是临床医生 主要的医疗中心，2个在国家癌症研究所任职，其余86个在学术界 职位包括2名教授、22名副教授、39名助理教授和23名讲师。 不包括仍在接受培训的研究员，其余104人中的90名前实习生已获得外部资金，用于 他们的研究包括37项被授予NIH K型个人奖的研究。带着现在 应用，我们寻求延续这一传统的培训领导在学术肿瘤学。 癌症研究的未来将继续取决于对高才华和 富有创造力的内科医生--对肿瘤疾病的临床方面有一定了解的科学家 能够将这些概念应用到肿瘤生物学和许多领域的适当实验室研究中 成为具有足够技能来指导研究计划、患者护理和教育的学术领袖 努力。这些人的发展只能在以下环境中完成 医生和科学家在物理相邻的地区工作，交流思想并在广泛的 一系列的努力。该计划将建立在卓越的内科肿瘤学基础上 在达纳-法伯/马萨诸塞州普通布里格姆医学肿瘤学奖学金的临床培训期间 程序。所有这些候选人都已经获得了医学博士或医学博士学位，完成了2到3年的 内科住院医师，至少一年的内科肿瘤学临床培训。 培训补助金计划将从这个人才库中挑选最合格的候选人，他们希望 在达纳-法伯癌症研究所或附近从事实验室研究或临床研究 机构。该计划将提供优秀的指导实验室和临床调查研究 资深和有经验的初级教员的经验和对招聘和指导的支持 代表不足的少数族裔研究员。预计在他们的训练结束后，这些人 在此培训计划的支持下，将有能力设计、启动和完成个人临床或 实验室研究项目，将能够独立或在最低限度的监督下运作，并将 准备很快确立自己作为独立研究调查人员的地位。

项目成果

Addressing spirituality within the care of patients at the end of life: perspectives of patients with advanced cancer, oncologists, and oncology nurses.

• DOI: 10.1200/jco.2011.40.3766
• 发表时间: 2012-07-10
• 期刊: Journal of clinical oncology : official journal of the American Society of Clinical Oncology
• 作者: Phelps AC;Lauderdale KE;Alcorn S;Dillinger J;Balboni MT;Van Wert M;Vanderweele TJ;Balboni TA
• 通讯作者: Balboni TA

Cost-effectiveness of immune checkpoint inhibitors for microsatellite instability-high/mismatch repair-deficient metastatic colorectal cancer.

• DOI: 10.1002/cncr.31795
• 发表时间: 2019-01-15
• 期刊: Cancer
• 影响因子: 6.2

Circulating Tumor DNA Provides a Sneak Peek into Treatment Responses in Non-Small Cell Lung Cancer.

• DOI: 10.1158/0008-5472.can-19-0231
• 发表时间: 2019-03-15
• 期刊: Cancer research
• 影响因子: 11.2

Bridging the Divide: Student Grand Rounds at the Interface of Basic Science and Clinical Medicine.

• DOI: 10.1097/acm.0000000000003116
• 发表时间: 2020-04
• 期刊: Academic medicine : journal of the Association of American Medical Colleges

Functional genomics and cancer drug target discovery.

• 发表时间: 2010-06
• 期刊: Current opinion in molecular therapeutics
• 作者: S. Moody;J. Boehm;D. Barbie;W. Hahn