Short-term Mentored Career Development Award: Iron Metabolism, Brain Energetics,

短期指导职业发展奖：铁代谢、脑能量学、

• 批准号: 8213978
• 负责人: MICHAEL J WENGER
• 金额: $ 10.97万
• 依托单位: UNIVERSITY OF OKLAHOMA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-20 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8213978
• 关键词: Accounting; Affect; Area; Attention; Behavior; Biochemistry; Brain; Cognition; Cognitive; Collaborations; Complex; Computer Simulation; Consumption; Data; Development; Elderly; Electrophysiology (science); Elements; Energy Metabolism; Experimental Psychology; Goals; Infant; Iron; K-Series Research Career Programs; Knowledge; Learning; Link; Literature; Magnetic Resonance; Measurement; Measures; Mentors; Metabolic; Metabolism; Methods; Military Personnel; Modeling; Pattern; Perception; Performance; Physiological; Physiology; Population; Population Heterogeneity; Reading; Research; Research Personnel; Role; Spectrometry; Structure; Supplementation; Testing; Training; Validation; Woman; Work; Writing; brain behavior; brain metabolism; experience; improved; iron metabolism; mathematical model; meetings; men; micronutrient deficiency; research study

DESCRIPTION (provided by applicant): Iron deficiency (ID) is a highly-prevalent micronutrient deficiency, affecting a large proportion of the world's population. Of the numerous effects of ID, a class that has recently begun to receive systematic attention has been the impact on perceptual and cognitive performance, with a concomitant concern for brain structure and function. This research has documented both substantial deficits associated with ID and substantial restorative effects of iron repletion on perceptual and cognitive performance. It has also increased our knowledge of the effects of iron depletion and repletion on brain metabolism and function. However, what is currently missing in the literature is a means of systematically and mechanistically relating the effects of iron depletion and repletion on changes in brain states and perceptual and cognitive performance. Mathematical and computational modeling offers the means for relating these disparate levels of analysis (body, brain, and behavior). Ideally, modeling these kinds of complex relations is best done in multi-disciplinary collaborations, and one key to creating successful cross-disciplinary collaborations is a shared set of knowledge about the core elements of the research question. My training and experience in experimental psychology, mathematical modeling, and electrophysiology (EEG) has allowed me to develop an initial set of collaborations around the modeling of perceptual and cognitive effects of iron depletion and repletion. However, my ability to fully participate in these collaborations is limited by my lack of knowledge of iron physiology and the experimental methods and measures used to assess its sequelae. As such, I am requesting one year of support in order to be mentored in these areas by two internationally-recognized experts in ID. The immediate goals for this project are three: (a) Acquire knowledge of the foundational biochemistry and physiological and metabolic measurements needed for an understanding of iron physiology and the measurement of the effects of iron depletion and repletion. (b) Integrate this foundational knowledge with new and ongoing research in the field. (c) Apply all of the knowledge gained to a research question linking the three levels of analysis-body, brain, and behavior- needed for developing mechanistic models of the effects of iron depletion and repletion on perception and cognition. The long-term goal is to develop experimentally-testable mathematical models for the mechanistic role of iron in brain function and perceptual and cognitive behaviors. PUBLIC HEALTH RELEVANCE: The proposed project will investigate the potential for using patterns of EEG to estimate brain energy expenditures and energetic efficiency in the context of iron deficiency. This work will advance our understanding of the role of iron in the functioning of both compromised and healthy brains, and the ways in which iron repletion can improve brain function.

描述（由申请人提供）：缺铁（ID）是一种高度流行的微量营养素缺乏症，影响了世界上很大一部分人口。在ID的众多影响中，最近开始受到系统关注的一类是对感知和认知表现的影响，同时关注大脑结构和功能。这项研究记录了与ID相关的实质性缺陷和铁补充对感知和认知表现的实质性恢复作用。它也增加了我们对铁缺乏和铁补充对大脑代谢和功能影响的认识。然而，目前在文献中缺少的是一种系统地和机械地将铁缺乏和补充对大脑状态变化以及感知和认知表现的影响联系起来的方法。 数学和计算建模提供了将这些不同层次的分析（身体，大脑和行为）联系起来的方法。理想情况下，对这些复杂关系进行建模最好是在多学科合作中进行，而创建成功的跨学科合作的关键之一是共享有关研究问题核心要素的知识。我在实验心理学、数学建模和电生理学（EEG）方面的训练和经验使我能够围绕铁消耗和补充的感知和认知影响的建模开展初步合作。然而，由于我缺乏铁生理学知识以及用于评估其后遗症的实验方法和措施，我完全参与这些合作的能力受到限制。因此，我请求一年的支持，以便在这些领域得到两位国际公认的ID专家的指导。该项目的近期目标有三个：（a）获得了解铁生理学和测量铁消耗和补充的影响所需的基础生物化学和生理代谢测量的知识。(b)将这些基础知识与该领域新的和正在进行的研究相结合。(c)将获得的所有知识应用于一个研究问题，该研究问题将身体、大脑和行为三个层次的分析联系起来，这三个层次是开发铁缺乏和铁补充对感知和认知影响的机械模型所需的。长期目标是开发实验可测试的数学模型，用于铁在大脑功能和感知和认知行为中的机械作用。 公共卫生相关性：拟议的项目将调查使用脑电图模式来估计缺铁情况下的大脑能量消耗和能量效率的潜力。这项工作将促进我们对铁在受损和健康大脑功能中的作用的理解，以及铁补充可以改善大脑功能的方式。