Iron Status at Perimenopause: Effects on Brain and Behavior

围绝经期的铁状况：对大脑和行为的影响

• 批准号: 9788455
• 负责人: MICHAEL J WENGER
• 金额: $ 19.57万
• 依托单位: UNIVERSITY OF OKLAHOMA
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-30 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9788455
• 关键词: Address; Adverse effects; Affect; Age; Amenorrhea; Attention; Behavior; Behavioral; Blood; Brain; Brain region; Brain scan; Cognition; Cognitive; Data; Dependence; Deposition; Disease; Elderly; Ferritin; Hemorrhage; Impaired cognition; Iron; Iron deficiency anemia; Learning; Life; Link; Literature; Longitudinal Studies; Measures; Memory; Menarche; Menopause; Motivation; National Health and Nutrition Examination Survey; Nature; Nerve Degeneration; Oxidative Stress; Parkinson Disease; Performance; Perimenopause; Physical Performance; Play; Postmenopause; Premenopause; Race; Rest; Risk; Role; Structure; System; Testing; Time; Variant; Woman; Work; age group; age related; behavior measurement; brain behavior; brain health; brain tissue; child bearing; cognitive function; cognitive performance; examination questions; high risk; iron deficiency; neurophysiology; procedural memory; recruit

Project summary/abstract From the onset of menarche, through the child-bearing years, a substantial number of women worldwide are challenged by iron deficiency (ID) or iron deficiency anemia (IDA). The negative effects of ID include deficits in cognitive and physical performance. At and following menopause, however, the nature of the relationship between iron status and both cognitive performance and brain health is much more ambiguous, and the literature on these relationships is quite sparse, in spite of evidence suggesting that brain iron accumulation may play a role in neural degeneration and cognitive decline. One intriguing potential regularity in the literature is an inverse relationship between systemic levels of ferritin and performance on a range of memory tasks in peri- and post-menopausal women. This suggests that amenorrhea may produce differential changes in brain iron for women who are ID or IDA at or prior to menopause relative to those who are not. There are at least two competing possibilities. First, when blood loss stops, brain iron levels may accelerate in a manner inversely proportional to systemic iron levels. For ID women, this may reverse any deficits that may be due to ID, but accelerate the negative effects of iron deposits (including oxidative stress) in specific brain regions, including those critical to attention and memory. Second, the rate of brain iron accumulation may have no relationship to iron status at menopause. For women who are ID, this would mean that brain iron levels, although increasing over time (and thus, eventually, reversing any ID-related deficits) would remain lower than those of women who are iron sufficient (IS), possibly conferring a protective benefit with respect to the adverse effects of accumulating iron on brain tissue and function. The ability to address these possibilities depends on the feasibility of measuring relationships among levels of iron in the blood, levels of iron in brain in regions known to be involved in specific aspects of cognition, brain dynamics during cognitive work and at rest, and behavioral measures of specific aspects of cognition. This project will be, to our knowledge, the first to assess the feasibility of assessing all of these relationships. A set of non-anemic pre-, peri-, and post-menopausal women, half of whom have low levels of blood iron and half of whom are sufficient, will provide structural brain scans for region-specific estimates of brain iron. They will be tested on behavioral measures of cognitive performance that selectively engage those regions while having brain activity measured using electroencephelography (EEG), and will also have EEG recorded during two periods of rest. All of this will allow for the first known quantitative characterization of the relationships among blood and brain iron levels, brain dynamics (both at work and at rest), and behavior, all relative to the onset of menopause. This cross-sectional characterization will provide the data that are critically needed for an efficient longitudinal examination of these questions, and will represent a unique contribution to a now-sparse literature on the relationship between iron and brain health and cognition in women in later life.

项目概要/摘要 从初潮开始到生育年龄，全世界有相当多的女性 受到缺铁（ID）或缺铁性贫血（IDA）的挑战。 ID 的负面影响包括 认知和身体表现。然而，在更年期及绝经后，两者之间关系的性质 铁的状态以及认知表现和大脑健康的情况要模糊得多，有关这些的文献 尽管有证据表明脑铁积累可能在神经系统中发挥作用，但这种关系相当稀疏。 退化和认知能力下降。 文献中一个有趣的潜在规律是铁蛋白全身水平之间的反比关系 以及围绝经期和绝经后妇女在一系列记忆任务中的表现。这表明闭经可能会对绝经前或绝经前患有 ID 或 IDA 的女性产生脑铁的差异变化 对于那些不是的人。至少存在两种​​相互竞争的可能性。首先，当失血停止时，脑铁水平 可能以与全身铁水平成反比的方式加速。对于 ID 女性来说，这可能会扭转任何 缺陷可能是由于ID引起的，但会加速铁沉积物（包括氧化应激）的负面影响 特定的大脑区域，包括那些对注意力和记忆至关重要的区域。其次，脑铁积累率可能与绝经期铁状态无关。对于智力障碍女性来说，这意味着大脑 铁含量虽然随着时间的推移而增加（因此，最终扭转任何与 ID 相关的缺陷），但仍将保持不变 低于铁充足（IS）的女性，可能对铁质有保护作用 铁积累对脑组织和功能的不利影响。 解决这些可能性的能力取决于衡量级别之间关系的可行性 血液中铁的含量、大脑中已知参与认知、大脑特定方面的区域的铁水平 认知工作和休息期间的动态，以及认知特定方面的行为测量。这个项目 据我们所知，将是第一个评估评估所有这些关系的可行性的人。一组非贫血的绝经前、围绝经期和绝经后女性，其中一半的血铁水平较低，一半的女性 就足够了，将为脑铁的特定区域估计提供结构性脑扫描。他们将接受测试 认知表现的行为测量，在大脑活动时选择性地参与这些区域 使用脑电图（EEG）进行测量，并且还将在两个休息期间记录脑电图。全部 这将有助于对血液和脑铁之间的关系进行首次已知的定量表征 水平、大脑动态（工作时和休息时）和行为，所有这些都与更年期的开始有关。这种横截面表征将提供有效纵向检查所必需的数据 这些问题，并将为现在稀疏的关于两者之间关系的文献做出独特的贡献 铁与女性晚年的大脑健康和认知。