Geriatric Oncology Research Infrastructure to Improve Clinical Care

摘要 这项为期五年的R33拨款提案的总体目标是“改善老年肿瘤学研究基础设施”， 代表癌症和衰老研究小组（CARG; mycarg.org）提交的“临床护理”报告旨在 进一步扩大CARG的国家研究基础设施，以支持创新的研究人员，领导者， 和项目，以回答重大的跨学科研究问题，在老龄化和癌症 接口.该提案是对PAR 20-071的回应，支持“高级阶段的开发和利用， 新的研究基础设施，以推进需要跨学科的特定领域的老龄科学 合作或合作”。即使在建立了强大的老龄化和癌症研究基础设施之后， 在过去五年中，通过R21/33机制，仍有大量未满足的需求， 扩大这一基础设施，在老龄化和癌症界面开展高影响力的研究。的 总体目标仍然是通过以下措施显著和迅速改善老年癌症患者的生活 奖学金和领导通过扩大CARG的影响。在R21/33机制的支持下， 多名主要研究者（MPI：Dale、Mohile、Hurria/Klepin）完成了一项协调的、基础广泛的 将衰老原理注入肿瘤学研究的战略。通过原始赠款的目的，CARG已 成为一个公认的国际领导者的导师和奖学金在老龄化和癌症。CARG是一个 老龄化和癌症学者联盟致力于：1）将跨学科研究人员联系在一起; 2） 设计，实施和传播老龄化和癌症研究; 3）指导新的跨学科 该领域的调查人员; 4）传播和倡导对老年人的公平研究和护理。 为了超越R21/R33奖项的目标，CARG成功地从基础设施开发过渡到 (R21)建立（R33），围绕六个核心和一个领导团队。此次R33更新是 寻求通过以下目标扩大CARG的影响：1）扩大基础设施的覆盖范围， 使用核心，以促进CARG的衰老和癌症研究的设计和严谨性; 2）促进高优先级， 在老龄化和癌症的接口有影响力的研究，通过试点奖励和大型，有竞争力的行为， 多中心研究; 3）识别，培养和指导CARG研究人员在老龄化和癌症研究中的领导地位 培养该领域的下一代领导者; 4）增强与老年患者接触的能力 通过CARG的患者倡导小组（SCOREboard）与癌症和护理人员合作，进一步发展以患者为中心的 老龄化和癌症研究;和5）开发和传播老年肿瘤学的具体内容，包括最好的 临床实践，研究结果，以及通过一个强大的合作和宣传机会， 沟通战略。最终，拟议的活动将大大扩大CARG的基础设施， 推进旨在改善全球老年癌症患者护理的高影响力研究。

ABSTRACT The overall goal of this five year R33 grant proposal, “Geriatric Oncology Research Infrastructure to Improve Clinical Care,” submitted on behalf of the Cancer and Aging Research Group (CARG; mycarg.org), is to further expand CARG’s national research infrastructure to support innovative investigators, leaders, and projects to answer significant interdisciplinary research questions at the aging and cancer interface. This proposal, in response to PAR 20-071, supports “advanced-stage development and utilization of novel research infrastructure to advance the science of aging in specific areas requiring interdisciplinary partnerships or collaborations.” Even after creating a robust aging and cancer research infrastructure over the last five years through the R21/33 mechanism, there remains substantial unmet need to expand this infrastructure to develop high-impact research at the aging and cancer interface. The overall goal remains to significantly and rapidly improve the lives of older adults with cancer through scholarship and leadership by expanding CARG’s impact. With the support of the R21/33 mechanism, the multiple Principal Investigators (MPI: Dale, Mohile, Hurria/Klepin) completed a coordinated, broad-based strategy to infuse aging principles into oncology research. Through the original grant’s Aims, CARG has become a recognized international leader for mentorship and scholarship in aging and cancer. CARG is a coalition of aging and cancer scholars dedicated to: 1) connecting interdisciplinary investigators together; 2) designing, implementing, and disseminating aging and cancer research; 3) mentoring new interdisciplinary investigators in the field; and 4) disseminating and advocating for equitable research and care for older adults. In exceeding the aims of the R21/R33 award, CARG successfully transitioned from infrastructure development (R21) to establishment (R33), centering around six Cores and a Leadership Team. This R33 renewal is sought to expand CARG’s impact through the following Aims: 1) Expand the reach of the infrastructure, using the Cores, to facilitate the design and rigor of CARG’s aging and cancer research; 2) Facilitate high-priority, impactful research at the interface of aging and cancer through pilot awards and the conduct of large, competitive multi-site studies; 3) Identify, cultivate, and mentor CARG investigators for leadership in aging and cancer research to develop the next generation of leaders in the field; 4) Build greater capacity for engagement with older patients with cancer and caregivers through CARG’s patient advocacy group (SCOREboard) to further grow patient-centered aging and cancer research; and 5) Develop and disseminate geriatric oncology-specific content including best clinical practices, research findings, and opportunities for collaboration and advocacy through a robust communication strategy. Ultimately, the proposed activities will substantially expand CARG’s infrastructure to advance high-impact research aimed at improving the care of older adults with cancer globally.