Geriatric Oncology Research Infrastructure to Improve Clinical Care

改善临床护理的老年肿瘤学研究基础设施

• 批准号: 10180832
• 负责人: WILLIAM DALE
• 金额: $ 83.49万
• 依托单位: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-04-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10180832
• 关键词: Address; Age; Aging; Applications Grants; Award; Caring; Clinical Research; Collaborations; Communication; Communities; Country; Data; Development; Elderly; Financial Support; Fostering; Foundations; Goals; Grant; Group Identifications; Individual; Infrastructure; Interdisciplinary Study; Knowledge; Link; Malignant Neoplasms; Manuscripts; Mentors; National Cancer Institute; National Institute on Aging; Oncology; Paper; Patients; Phase; Population; Primary Health Care; Principal Investigator; Productivity; Research; Research Infrastructure; Research Personnel; Research Priority; Research Project Grants; Research Support; Resources; Secure; Series; Site; Solid; anticancer research; base; cancer care; career development; clinical care; design; improved; innovation; member; older patient; rapid growth; research and development; response; success; symposium

The overall goal of this 5-year R21/R33 grant proposal, “Geriatric Oncology Research Infrastructure to Improve Clinical Care,” submitted on behalf of the Cancer and Aging Research Group (CARG), is to establish a sustainable national research infrastructure to facilitate and support significant innovative projects addressing key interdisciplinary research questions at the aging and cancer interface. This proposal addresses a key scientific priority highlighted in PAR 16-367, the “development of research infrastructure to facilitate clinical studies involving geriatric cancer populations.” Despite the rapid growth of the older adult cancer population, there is a substantial unmet need to coordinate resources, expertise, and data to support research at the aging and cancer interface. The Principal Investigators (Multi-PIs) of this proposal, Drs. Dale, Hurria, and Mohile, recognized this need and embarked on two major efforts. First, in 2007, they led the creation and development of CARG (www.mycarg.org), a coalition of investigators dedicated to: 1) linking existing interdisciplinary aging and cancer researchers together; 2) supporting the development of high quality aging and cancer research; and 3) fostering new researchers in aging and cancer. Remarkably, this grassroots approach has created success beyond its modest, mostly local resources. Second, the Multi-PIs secured a 5-year U13 grant (U13 AG038151; PI: Hurria, co-PIs: Mohile and Dale) “Geriatric Oncology Research to Improve Clinical Care,” in collaboration with the National Institute on Aging and the National Cancer Institute which supported 3 conferences, bringing together national leaders to identify research priorities in aging and cancer. The development of CARG and the identification of research priorities through the U13 grant set a solid foundation; however, to accelerate research efforts, a more robust infrastructure is needed to facilitate and foster interdisciplinary, collaborative research in aging and cancer, focus on the career development of investigators to grow the field, and widely disseminate the research findings. Therefore, the aims of the proposal are to: 1. Solidify the infrastructure and expertise, in the form of Cores, needed to facilitate the design of impactful aging and cancer research based on U13 priorities; 2. Utilize the sustainable infrastructure to foster collaborations among a range of interdisciplinary investigators across the nation to accelerate innovative research in aging and cancer; 3. Support and guide high-priority research projects at the interface of aging and cancer to lay the foundation for competitive multi-site studies; 4. Identify, cultivate, and mentor investigators in aging and cancer research; and 5. Disseminate through effective communication strategies the research findings and data-sharing opportunities to the larger community. Ultimately, these proposed activities will lead to a sustainable infrastructure that supports high-impact research aimed at improving the care of older adults with cancer.

这项为期5年的R21/R33拨款提案的总体目标是“老年肿瘤学研究基础设施， 改善临床护理，”代表癌症和衰老研究小组（CARG）提交，是为了建立 可持续的国家研究基础设施，以促进和支持重大创新项目， 在衰老和癌症界面的关键跨学科研究问题。这项提案涉及一个关键问题， PAR 16-367中强调的科学优先事项，“发展研究基础设施，促进临床 涉及老年癌症人群的研究。”尽管老年癌症患者人数迅速增长， 在协调资源、专业知识和数据以支持老龄化研究方面， 和癌症接口。本提案的主要研究者（多PI）Dale、Hurria和Mohile博士， 认识到这一需要，并开始了两项重大努力。首先，在2007年，他们领导了创建和开发 CARG（www.mycarg.org）是一个研究人员联盟，致力于：1）将现有的跨学科老龄化联系起来 2）支持高质量的老龄化和癌症研究的发展; （3）培养衰老和癌症的新研究人员。值得注意的是，这种基层方法创造了 成功超越了其有限的，主要是当地资源。第二，多项目研究所获得了为期5年的U13赠款（U13 AG 038151; PI：Hurria，co-PI：Mohile和Dale）“老年肿瘤学研究以改善临床护理”， 与国家老龄化研究所和国家癌症研究所合作， 会议，汇集国家领导人，确定衰老和癌症的研究优先事项。的 CARG的发展和通过U13赠款确定研究优先事项奠定了坚实的基础; 然而，为了加快研究工作，需要一个更强大的基础设施，以促进和促进 跨学科，在老龄化和癌症的合作研究，重点是研究人员的职业发展 扩大研究领域，广泛传播研究成果。因此，该提案的目的是：1. 以核心的形式巩固基础设施和专业知识，以促进有影响力的老化设计， 基于U13优先事项的癌症研究; 2.利用可持续的基础设施，促进 一系列跨学科的研究人员在全国范围内，以加快创新研究的老化和癌症; 3。 支持和指导老龄化和癌症界面的高优先级研究项目，为以下方面奠定基础 竞争性多中心研究; 4.识别，培养，并指导研究人员在老龄化和癌症研究;和5。 通过有效的沟通策略传播研究成果和数据共享机会 到更大的社区。最终，这些拟议的活动将导致可持续的基础设施， 支持旨在改善老年癌症患者护理的高影响力研究。