Geriatric Oncology Research Infrastructure to Improve Clinical Care

这项为期5年的R21/R33拨款提案的总体目标是：“老年肿瘤研究基础设施 代表癌症和老龄化研究小组(CARG)提交的《改善临床护理》旨在建立 可持续的国家研究基础设施，以促进和支持重大创新项目 老龄化和癌症界面的关键跨学科研究问题。这项建议解决了一个关键问题 在PAR 16-367中强调了科学优先事项，即“发展研究基础设施，以促进临床 涉及老年癌症人群的研究。尽管老年癌症人口迅速增长， 有大量未得到满足的需求需要协调资源、专业知识和数据以支持老龄化研究 和癌症的接口。该提案的首席调查员(多PI)Dale博士、Hurria博士和Mohile博士， 认识到这一需要，开始了两项主要努力。首先，在2007年，他们领导了 GARG(www.mycarg.org)的研究人员联盟致力于：1)将现有的跨学科老龄化联系起来 和癌症研究人员共同努力；2)支持高质量老龄化和癌症研究的发展； 3)培养老龄化和癌症领域的新研究人员。值得注意的是，这种草根方法创造了 成功超越了其有限的、主要是当地的资源。其次，多项私人投资机构获得了为期5年的U13拨款(U13 AG038151；PI：Hurria，共同PI：Mohile and Dale)，《改善临床护理的老年肿瘤学研究》，in 与国家老龄研究所和国家癌症研究所合作，支持3 会议，将各国领导人聚集在一起，确定老龄化和癌症的研究重点。这个 发展联合评估小组，并通过U13赠款确定研究重点，奠定了坚实的基础； 然而，为了加快研究工作，需要更强大的基础设施来促进和促进 在老龄化和癌症方面的跨学科、协作研究，专注于研究人员的职业发展 扩大这一领域，并广泛传播研究成果。因此，这项建议的目的是：1. 以核心的形式巩固基础设施和专业知识，以促进有效老化和 基于U13优先事项的癌症研究；2.利用可持续的基础设施促进 在全国范围内开展跨学科调查，以加快老龄化和癌症方面的创新研究； 支持和指导老龄化与癌症交界处的高优先级研究项目，为 竞争性多点研究；4.识别、培养和指导衰老和癌症研究方面的研究人员；以及5. 通过有效的沟通策略传播研究成果和数据共享机会 对更大的社区来说。最终，这些拟议的活动将导致一个可持续的基础设施 支持旨在改善对患有癌症的老年人的护理的高影响力研究。

The overall goal of this 5-year R21/R33 grant proposal, “Geriatric Oncology Research Infrastructure to Improve Clinical Care,” submitted on behalf of the Cancer and Aging Research Group (CARG), is to establish a sustainable national research infrastructure to facilitate and support significant innovative projects addressing key interdisciplinary research questions at the aging and cancer interface. This proposal addresses a key scientific priority highlighted in PAR 16-367, the “development of research infrastructure to facilitate clinical studies involving geriatric cancer populations.” Despite the rapid growth of the older adult cancer population, there is a substantial unmet need to coordinate resources, expertise, and data to support research at the aging and cancer interface. The Principal Investigators (Multi-PIs) of this proposal, Drs. Dale, Hurria, and Mohile, recognized this need and embarked on two major efforts. First, in 2007, they led the creation and development of CARG (www.mycarg.org), a coalition of investigators dedicated to: 1) linking existing interdisciplinary aging and cancer researchers together; 2) supporting the development of high quality aging and cancer research; and 3) fostering new researchers in aging and cancer. Remarkably, this grassroots approach has created success beyond its modest, mostly local resources. Second, the Multi-PIs secured a 5-year U13 grant (U13 AG038151; PI: Hurria, co-PIs: Mohile and Dale) “Geriatric Oncology Research to Improve Clinical Care,” in collaboration with the National Institute on Aging and the National Cancer Institute which supported 3 conferences, bringing together national leaders to identify research priorities in aging and cancer. The development of CARG and the identification of research priorities through the U13 grant set a solid foundation; however, to accelerate research efforts, a more robust infrastructure is needed to facilitate and foster interdisciplinary, collaborative research in aging and cancer, focus on the career development of investigators to grow the field, and widely disseminate the research findings. Therefore, the aims of the proposal are to: 1. Solidify the infrastructure and expertise, in the form of Cores, needed to facilitate the design of impactful aging and cancer research based on U13 priorities; 2. Utilize the sustainable infrastructure to foster collaborations among a range of interdisciplinary investigators across the nation to accelerate innovative research in aging and cancer; 3. Support and guide high-priority research projects at the interface of aging and cancer to lay the foundation for competitive multi-site studies; 4. Identify, cultivate, and mentor investigators in aging and cancer research; and 5. Disseminate through effective communication strategies the research findings and data-sharing opportunities to the larger community. Ultimately, these proposed activities will lead to a sustainable infrastructure that supports high-impact research aimed at improving the care of older adults with cancer.