Mentoring the Next Generation of Geriatric Oncology and Supportive Care Researchers in Patient-Oriented Research to Improve the Care of Older Adults with Cancer

指导下一代老年肿瘤学和支持性护理研究人员进行以患者为导向的研究，以改善患有癌症的老年人的护理

• 批准号: 10807909
• 负责人: WILLIAM DALE
• 金额: $ 18.57万
• 依托单位: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-12-01 至 2028-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10807909
• 关键词: Achievement; Address; Age; Aging; American; American Society of Clinical Oncology; Award; Cancer Center; Cancer Patient; Caring; Cessation of life; Cities; Communities; Country; Data; Data Reporting; Databases; Dedications; Development; Development Plans; Diagnosis; Disease; Doctor of Philosophy; Educational process of instructing; Elderly; Ensure; Equity; Faculty; Fostering; Foundations; Funding; Future; Geriatric Assessment; Geriatrics; Goals; Grant; Guidelines; Health; Incidence; Individual; Infrastructure; Inherited; Institute of Medicine (U.S.); Intervention; Intervention Trial; Latinx; Lead; Leadership; Learning Skill; Left; Malignant Neoplasms; Mentored Patient-Oriented Research Career Development Award; Mentors; Mentorship; Mexico; Midcareer Investigator Award in Patient-Oriented Research; National Cancer Institute; National Institute on Aging; Oncology; Outcome; Patient-Centered Care; Patient-Focused Outcomes; Patients; Persons; Population; Provider; Publications; Publishing; Recommendation; Research; Research Personnel; Resources; Risk; Risk Factors; Scholarship; Secure; Site; Standardization; Supportive care; Surveys; Toxic effect; Toxicity due to chemotherapy; Training; United States National Institutes of Health; Update; Vision; Work; cancer therapy; career; career development; clinical implementation; clinical practice; community setting; driving force; evidence base; high risk; human old age (65+); improved; infrastructure development; innovation; meetings; member; mid-career faculty; multidisciplinary; next generation; older patient; patient navigation; patient oriented research; prevent; programs; scale up; skills; standard of care; treatment optimization

ABSTRACT I have two overall career goals, which directly align with the aims of this proposal: 1) to generate high quality patient- oriented research at the nexus of geriatric oncology and supportive care interventions, generating the critically needed evidence to inform and improve the care of older adults with cancer through the use of new infrastructure underlying the City of Hope’s Center for Cancer and Aging and the national Cancer and Aging Research Group (CARG), both of which I lead; and 2) to mentor the next generation of geriatric oncology and supportive care scholars and future leaders in patient-oriented research based on newly-created infrastructure to ensure a healthy cadre of well-trained researchers in aging and cancer poised to sustain the field. This is important because one in three Americans over the age of 60 will be diagnosed with cancer in their lifetime. From 2010 to 2030, cancer incidence is expected to rise 67% for individuals age ≥ 65, making cancer a disease of aging. Dr. Arti Hurria, my close colleague from whom I inherited this award, dedicated her career to developing and validating the CARG Geriatric Assessment (GA) and conducting evidence-based research showing the positive patient-centered outcomes of GA-guided care. I am carrying out her vision cut short with her death. Although GA is now considered the standard of care, only 20% of older patients with cancer receive a GA in the community setting. The goal of this K24 Renewal for the Midcareer Investigator Award in Patient-Oriented Research is to: 1) unite the fields of geriatrics, oncology, and supportive care by building and sustaining the infrastructure to provide equitable patient-centered care for an aging oncology population, and 2) mentor the next generation of geriatric oncology and supportive care investigators and future leaders using this infrastructure. There are three components proposed in this application. The first is a comprehensive mentoring program to foster the career development of trainees from diverse backgrounds by teaching patient-oriented research skills for geriatric oncology and supportive care. This includes the development of an individualized career development plan that will enable each mentee to learn the skills of patient-oriented research; 1:1 mentor-mentee meetings; and seminars and coursework to foster mentees’ career development. The second component is to leverage the recently received infrastructure grants (NIA R33 grant, Rising Tide Foundation GOTO Grant, PI: W. Dale) to support the conduct of patient-oriented research focused on improving the care of older adults with cancer. The third component is my own career development plan, which will include expanding recent interventional and implementation work’s impact by leveraging newly developed infrastructure, and expanding my skill set in national aging scholarship through 1:1 mentoring. The research, mentorship, and training proposed in this application address key priorities identified by the National Institute of Aging, National Cancer Institute, Institute of Medicine, and American Society of Clinical Oncology to improve the care of older adults with cancer.

摘要 我有两个总体的职业目标，这直接符合本提案的目标：1）产生高质量的病人- 以老年肿瘤学和支持性护理干预措施的关系为导向的研究， 需要证据通过使用新的基础设施来告知和改善老年癌症患者的护理 作为希望之城癌症与衰老中心和国家癌症与衰老研究小组的基础， （CARG），这两个都是我领导的; 2）指导下一代老年肿瘤学和支持性护理学者 和未来的领导者在以病人为导向的研究基础上新创建的基础设施，以确保健康的干部， 训练有素的衰老和癌症研究人员准备维持这一领域。这很重要，因为三分之一的人 60岁以上的美国人一生中将被诊断出患有癌症。2010年至2030年，癌症发病率为 年龄≥ 65岁的人预计会增加67%，使癌症成为一种衰老疾病。阿尔蒂胡里亚医生，我的亲密同事 我从她那里继承了这个奖项，她的职业生涯致力于开发和验证CARG老年评估 (GA)并进行循证研究，显示GA指导的护理以患者为中心的积极成果。我 我正在实现她的梦想，但她的死却打断了我虽然GA现在被认为是标准的护理，但只有20%的 患有癌症的老年患者在社区环境中接受GA。本次K24职业中期更新的目标是 研究者奖以患者为导向的研究是：1）团结老年医学，肿瘤学和支持领域 通过建立和维持基础设施，为老年肿瘤提供公平的以患者为中心的护理 人口，2）指导下一代老年肿瘤学和支持性护理研究者和未来 领导者使用这些基础设施。在本申请中提出了三个组件。第一个是 全面的辅导计划，以促进来自不同背景的学员的职业发展， 教授老年肿瘤学和支持性护理的以患者为导向的研究技能。这包括发展 个性化的职业发展计划，使每个学员都能学习以病人为导向的技能， 研究; 1：1导师-学员会议;以及促进学员职业发展的研讨会和课程。的 第二个组成部分是利用最近收到的基础设施赠款（NIA R33赠款，涨潮基金会 后藤格兰特，PI：W。戴尔），以支持开展以病人为导向的研究，重点是改善老年人的护理 患有癌症的成年人。第三个组成部分是我自己的职业发展计划，其中将包括扩大最近的 通过利用新开发的基础设施，扩大我的 通过1：1指导获得国家老龄奖学金的技能。建议的研究、指导和培训 本申请解决了由国家老龄化研究所，国家癌症研究所， 医学研究所和美国临床肿瘤学会，以改善老年人的护理， 癌

项目成果

Signal Variability and Cognitive Function in Older Long-Term Survivors of Breast Cancer with Exposure to Chemotherapy: A Prospective Longitudinal Resting-State fMRI Study.

• DOI: 10.3390/brainsci12101283
• 发表时间: 2022-09-23
• 期刊: BRAIN SCIENCES
• 影响因子: 3.3
• 作者: Chen, Bihong T.;Chen, Zikuan;Deng, Frank;Patel, Sunita K.;Sedrak, Mina S.;Root, James C.;Ahles, Tim A.;Razavi, Marianne;Kim, Heeyoung;Sun, Can-Lan;Dale, William
• 通讯作者: Dale, William

Improving Care for Spanish-Speaking Older Adults with Breast Cancer: Feasibility, Reliability, and Validity of a Self-Administered Spanish Language Geriatric Assessment.

• DOI: 10.3390/cancers13112685
• 发表时间: 2021-05-29
• 期刊: Cancers
• 影响因子: 5.2
• 作者: Soto-Perez-de-Celis E;Vazquez J;Kim H;Sun CL;Charles K;Celis A;Katheria V;Li D;Dale W;Sedrak MS
• 通讯作者: Sedrak MS

The epidemiology of social isolation and loneliness among older adults during the last years of life.

• DOI: 10.1111/jgs.17366
• 发表时间: 2021-11
• 期刊: Journal of the American Geriatrics Society
• 影响因子: 6.3
• 作者: Kotwal AA;Cenzer IS;Waite LJ;Covinsky KE;Perissinotto CM;Boscardin WJ;Hawkley LC;Dale W;Smith AK
• 通讯作者: Smith AK

Predictors of hospital readmission among older adults with cancer.

• DOI: 10.1016/j.jgo.2020.03.008
• 发表时间: 2020-09
• 期刊: Journal of geriatric oncology
• 影响因子: 3
• 作者: Burhenn P;Sun CL;Scher KS;Hsu J;Pandya P;Chui CY;Arsenyan A;Mitani D;Morrison R;Katheria V;Hurria A
• 通讯作者: Hurria A

Association between patient-reported hearing and visual impairments and functional, psychological, and cognitive status among older adults with cancer.

• DOI: 10.1002/cncr.31540
• 发表时间: 2018-08-01
• 期刊: Cancer
• 影响因子: 6.2
• 作者: Soto-Perez-de-Celis E;Sun CL;Tew WP;Mohile SG;Gajra A;Klepin HD;Owusu C;Gross CP;Muss HB;Lichtman SM;Chapman AE;Cohen HJ;Dale W;Kim H;Fernandes S;Katheria V;Hurria A
• 通讯作者: Hurria A