High-Speed, Low-Cost, Image Remapping Spectral Domain Full-Field Optical Coherence Tomography for Retinal Imaging

用于视网膜成像的高速、低成本图像重映射谱域全场光学相干断层扫描

• 批准号: 10670648
• 负责人: Brian E. Applegate
• 金额: $ 25.04万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10670648
• 关键词: 3-Dimensional; 3D Print; Adoption; Algorithms; Angiography; Clinical; Defect; Developing Countries; Development; Diagnostic Imaging; Diameter; Diamond; Doctor of Philosophy; Early Diagnosis; Engineering; Environment; Fiber; Frequencies; General Practitioners; Human; Image; Interferometry; Labyrinth; Lasers; Lateral; Light; Maps; Measures; Microfabrication; Microscope; Morphologic artifacts; Motion; Noise; Operative Surgical Procedures; Optical Coherence Tomography; Optics; Optometrist; Patients; Performance; Phase; Population; Printing; Refractive Errors; Resolution; Retina; Retinal Diseases; Rural; Sampling; Scanning; Scientist; Signal Transduction; Source; Speed; Structure; Surface; System; Techniques; Technology; Time; Validation; Visual; Work; accurate diagnosis; adaptive optics; clinical application; clinical imaging; commercialization; cost; design; digital; experience; fabrication; human data; human imaging; imaging system; improved; instrument; lithography; manufacture; meter; middle ear; nano; new technology; novel; novel strategies; pediatric patients; photonics; remote sensing; retinal imaging; sample fixation; screening; sensor; standard of care; technology development; tissue phantom; trend; vibration

Optical Coherence Tomography (OCT) has profoundly impacted diagnostic imaging of the human retina, enabling accurate and early diagnosis of retinal disease. The relatively high cost of current clinical instruments limits its use in cost sensitive environments, e.g. screening in the optometrist's or general practitioner's office, underserved or rural US populations and developing countries. Motion of the patient and/or interferometer strongly effects phase stability and image quality, impacting the common approaches which scan a focused beam across the retinal surface. Collecting the entire field at once via an approach such as Full-Field Optical Coherence Tomography (FF-OCT), would obviate this issue and provide high spatial phase stability. Here we propose a novel solution that not only overcomes these issues (poor phase stability and coherent artifact) but promises to do so while reducing costs and increasing imaging speed. We will take advantage of rapid development in two key technologies, additive manufacturing for optical components and extremely high megapixel CMOS arrays. Building on concepts from our prior work, we will develop an FF- OCT system by mapping the 3-dimensions (x,y, and k) onto a 2-D CMOS array within an imaging spectrometer. This will in turn allow us to utilize inexpensive spatially incoherent light sources which do not produce coherence artifacts, but heretofore were limited to use with time-domain FF-OCT systems. This will be accomplished via 3 Specific Aims. Aim 1, Develop a 3-D printed structure for image remapping in FF-OCT: We will deploy a micro- optical design consisting of arrays of 3-D printed single mode fibers that map x,y in the image plane, to spaced columns. The space between the columns will enable dispersion in k within the 2-D spectrometer developed in Aim 2. This structure will enable volumetric OCT imaging with a single camera exposure by mapping x, y, and k onto a 2-D array. Aim 2, Develop an imaging spectrometer and spectral domain FF-OCT system around a high megapixel (Mp) CMOS sensor: We will design and develop an imaging spectrometer that will be compatible with the structure(s) from aim 1, integrating the structures as they become available. Aim 3, System validation and human retinal imaging: After validation on tissue phantoms, pilot human data from a spectrum of retinal diseases will be acquired and compared with standard-of-care clinical imaging systems. We expect the completed system to have an FOV of 5 mm diameter, 15.5 µm lateral sampling, 7.5 µm axial resolution and be able to collect a volume image in as little as 200 µs at 48 volumes per second.

光学相干层析成像(OCT)对人体的诊断成像产生了深远的影响 视网膜，使准确和早期诊断视网膜疾病成为可能。当前相对较高的成本 临床仪器限制了其在成本敏感环境中的使用，例如在 验光师或全科医生办公室，服务不足或美国农村人口和发展中国家 国家。患者和/或干涉仪的运动强烈影响相位稳定性和图像 质量，影响常见的扫描聚焦光束穿过视网膜表面的方法。 通过全场光学相干性等方法一次采集整个场 层析成像(FF-OCT)将避免这一问题，并提供高空间相位稳定性。在这里我们 提出一种新的解决方案，不仅克服了这些问题(相位稳定性差和相干 人工制品)，但承诺这样做，同时降低成本和提高成像速度。我们会带上 两项关键技术快速发展的优势：光学加成制造 元器件和极高的百万像素cmos阵列。以我们以前的概念为基础 我们将通过将3维(x、y和k)映射到2-D来开发一个FF-OCT系统 成像光谱仪内的cmos阵列。这反过来将使我们能够利用廉价的 空间非相干光源，不产生相干伪影，但到目前为止 仅限于与时间域FF-OCT系统一起使用。这将通过三个具体目标来实现。 目标1，开发一种用于FF-OCT图像重新映射的3D打印结构：我们将部署一种微型 由3-D打印的单模光纤阵列组成的光学设计，这些光纤在图像中映射x，y 平面，到间隔的柱。列之间的间隔将使k中的色散在 在AIM 2中开发的2-D光谱仪。这种结构将使体积OCT成像具有 通过将x、y和k映射到2-D阵列进行单次相机曝光。 目的2、研制一台成像光谱仪和光谱域FF-OCT系统 百万像素(MP)CMOS传感器：我们将设计和开发一种成像光谱仪，它将是 与目标1中的结构(S)兼容，在结构可用时进行集成。 目标3，系统验证和人类视网膜成像：在组织模体上验证后， 将从一系列视网膜疾病中获取试点人类数据，并与 医疗标准临床影像系统。我们预计完成的系统的FOV将为5 毫米直径，15.5微米横向取样，7.5微米轴向分辨率，能够采集体积 S以每秒48卷的速度拍摄图像，最小可达200µm。