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NEI Center Core Grant for Vision Research

NEI 中心视觉研究核心资助

基本信息

批准号：
10670892
负责人：
BELA ANAND-APTE
金额：
$ 64.4万
依托单位：
CLEVELAND CLINIC LERNER COM-CWRU
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-09-01 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10670892
关键词：
Affect Award Basic Science Blindness Center Core Grants Clinic Clinical Collaborations Core Facility Core Grant Data Development Diabetic Retinopathy Disease Eligibility Determination Environment Equipment Eye Faculty Fostering Foundations Funding Generations Goals Grant Health Services Accessibility Image Individual Informatics Infrastructure Institution Laboratories Measures Mission Modification Molecular Productivity Publications Reporting Research Research Infrastructure Research Personnel Research Support Resolution Resource Sharing Resources Retinopathy of Prematurity Scientist Series Services Source Structure Techniques Technology Vision Vision research Visual System Work base cost cost effective experience inherited retinal degeneration instrumentation new technology ocular imaging operation prevent programs sight restoration skills square foot success translational research program vision science

项目摘要

Overall Core Project Summary The overall aim of the Cole Eye Institute (CEI) Core Facilities for Vision Research is to facilitate the analysis of the structure, function and disease mechanisms that affect the visual system by providing centralized assess to shared resources. The Core Facilities will provide resources, expertise and equipment to aid in the research endeavors of a vibrant and highly collaborative group of vision science investigators at CEI of the Cleveland Clinic Foundation. The long-term goal of the investigators served by this grant is to prevent blindness and restore vision in diseases such as Retinopathy of Prematurity, Diabetic Retinopathy. AMD and Inherited Retinal Degenerations. To this end we have developed a series of Core modules that will continue to provide state-of-the-art instrumentation and technologies required for vision research. The three Core modules are: (1) Ocular Imaging Core; (2) Functional Vision Core; and (3) Molecular Informatics Core. These Cores contain equipment that is maintained and operated by highly skilled technicians that are supervised by established research scientists. Consolidating these technologies into the three Cores allows us to bring these techniques and skills to all potential users in our program, which we anticipate will continue to increase productivity in the user laboratories and avoid duplication of equipment and effort. Successful operation of these three Cores will bring the best of these technologies to each of the NEI RO1 supported laboratories in this institution. We also envision that these Core modules will continue to enhance and sustain the collaborative scientific environment that is a strong feature of the CEI Vision research group. The Cores will also enhance productivity among the participating investigators as in the previous grant cycle and allow junior investigators to have access to services and research strategies that will help generate preliminary data to support new RO1 applications.

整体核心项目总结

项目成果

期刊论文数量（121）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Topical Losartan and Corticosteroid Additively Inhibit Corneal Stromal Myofibroblast Generation and Scarring Fibrosis After Alkali Burn Injury.

DOI：
10.1167/tvst.11.7.9
发表时间：
2022-07-08
期刊：
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
影响因子：
3
作者：
Sampaio, Lycia Pedral;Hilgert, Guilherme S. L.;Shiju, Thomas Michael;Santhiago, Marcony R.;Wilson, Steven E.
通讯作者：
Wilson, Steven E.

Corneal fibroblast collagen type IV negative feedback modulation of TGF beta: A fibrosis modulating system likely active in other organs.

DOI：
10.1016/j.matbio.2022.04.002
发表时间：
2022-04
期刊：
Matrix biology : journal of the International Society for Matrix Biology
影响因子：
0
作者：
S. Wilson;T. M. Shiju;L. P. Sampaio;G. L. Hilgert
通讯作者：
S. Wilson;T. M. Shiju;L. P. Sampaio;G. L. Hilgert

Texture-Based Radiomic SD-OCT Features Associated With Response to Anti-VEGF Therapy in a Phase III Neovascular AMD Clinical Trial.

DOI：
10.1167/tvst.13.1.29
发表时间：
2024-01-02
期刊：
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
影响因子：
3
作者：
Kar, Sudeshna Sil;Cetin, Hasan;Srivastava, Sunil K.;Madabhushi, Anant;Ehlers, Justis P.
通讯作者：
Ehlers, Justis P.

Visual imaging as a predictor of neurodegeneration in experimental autoimmune demyelination and multiple sclerosis.