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Project Summary An intact blood-retinal barrier (BRB) is critical for the maintenance of the health of the retina. The endothelial cells of the retinal blood vessels along with the surrounding pericytes and astrocytes form a neurovascular unit with strong barrier properties. Very little is known about the molecular and cellular mechanisms that regulate the development and maintenance of the BRB. We hypothesize that retinoic acid (RA) plays a critical role in the regulation of BRB formation as well as maintenance. We will test this hypothesis using a novel zebrafish model that we have developed, which allows the longitudinal in vivo visualization and testing of the BRB.
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Deep Learning Algorithm Detects Presence of Disorganization of Retinal Inner Layers (DRIL)-An Early Imaging Biomarker in Diabetic Retinopathy.
深度学习算法检测出视网膜内层(DRIL)的混乱的存在 - 糖尿病性视网膜病中的早期成像生物标志物。
DOI: 10.1167/tvst.12.7.6
发表时间: 2023-07-03
期刊: TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
影响因子: 3
作者: [Singh, Rupesh, Singuri, Srinidhi, Batoki, Julia, Lin, Kimberly, Luo, Shiming, Hatipoglu, Dilara, Anand-Apte, Bela, Yuan, Alex]
通讯作者: Yuan, Alex
Regulation of Choroidal Neovascularization in Sorsby's Fundus Dystrophy
  • 批准号:
    9900004
  • 项目类别:
  • 资助金额:
    $39.63万
  • 财政年份:
    2017
  • 负责人:
    BELA ANAND-APTE
  • 依托单位:
FGF and hyaluronan-mediated alterations in epithelial-mesenchymal transition and metabolism of RPE cells in Sorsby Fundus Dystrophy.
  • 批准号:
    10408757
  • 项目类别:
  • 资助金额:
    $62.17万
  • 财政年份:
    2017
  • 负责人:
    BELA ANAND-APTE
  • 依托单位:
FGF and hyaluronan-mediated alterations in epithelial-mesenchymal transition and metabolism of RPE cells in Sorsby Fundus Dystrophy.
  • 批准号:
    10636830
  • 项目类别:
  • 资助金额:
    $61.01万
  • 财政年份:
    2017
  • 负责人:
    BELA ANAND-APTE
  • 依托单位:
Role of Retinoic Acid in the Regulation of the Blood-Retinal Barrier.
  • 批准号:
    9769753
  • 项目类别:
  • 资助金额:
    $41.3万
  • 财政年份:
    2016
  • 负责人:
    BELA ANAND-APTE
  • 依托单位:
国内基金
海外基金
Ascl1介导Wnt/beta-catenin通路在TLE海马硬化中反应性Astrocytes异常增生的作用及调控机制
  • 批准号:
    31760279
  • 项目类别:
    地区科学基金项目
  • 资助金额:
    35.0万元
  • 批准年份:
    2017
  • 负责人:
    丁银秀
  • 依托单位: