Role of Retinoic Acid in the Regulation of the Blood-Retinal Barrier.
Role of Retinoic Acid in the Regulation of the Blood-Retinal Barrier.
批准号:
10011815
负责人:
BELA ANAND-APTE
金额:
$41.3万
依托单位国家:
美国
项目类别:
财政年份:
2016
资助国家:
美国
项目状态:
已结题
起止时间:
2016-09-01 至 2022-08-31
关键词:
AddressAstrocytesBiological ModelsBlindnessBlood TestsBlood VesselsBlood-Retinal BarrierCellsCommunicationCuesCultured CellsDataDevelopmentDevelopmental ProcessDiseaseEndothelial CellsEnvironmentEnzymesExtravasationGenesGeneticGoalsHandHealthHemorrhageIn SituLaboratoriesLasersLeadMaintenanceMammalsModelingMolecularNatural regenerationOphthalmoscopyPathway interactionsPatternPerfusionPericytesPhasePhenotypePhysiologicalPhysiological ProcessesPlasmaPlayProcessProductionPropertyRegulationReportingResearchRetinaRodentRoleScanningSignal PathwaySignal TransductionTestingTight JunctionsTimeTissuesTransgenic OrganismsTretinoinValidationVegf InhibitorVisualizationWNT Signaling PathwayZebrafishbasecourse developmentenhanced green fluorescent proteinin vitro Modelin vivoin vivo Modelin vivo imaginginsightneurovascular unitnoveloverexpressionretina blood vessel structureretinal imagingsealtool
中文摘要
点击翻译按钮获取中文摘要
英文摘要
Project Summary
An intact blood-retinal barrier (BRB) is critical for the maintenance of the health of the retina. The endothelial
cells of the retinal blood vessels along with the surrounding pericytes and astrocytes form a neurovascular unit
with strong barrier properties. Very little is known about the molecular and cellular mechanisms that regulate
the development and maintenance of the BRB. We hypothesize that retinoic acid (RA) plays a critical role in
the regulation of BRB formation as well as maintenance. We will test this hypothesis using a novel zebrafish
model that we have developed, which allows the longitudinal in vivo visualization and testing of the BRB.
期刊论文(1)
专著(0)
科研奖励(0)
会议论文
Deep Learning Algorithm Detects Presence of Disorganization of Retinal Inner Layers (DRIL)-An Early Imaging Biomarker in Diabetic Retinopathy.
深度学习算法检测出视网膜内层(DRIL)的混乱的存在 - 糖尿病性视网膜病中的早期成像生物标志物。
DOI:
10.1167/tvst.12.7.6
发表时间:
2023-07-03
期刊:
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
影响因子:
3
作者:
[Singh, Rupesh, Singuri, Srinidhi, Batoki, Julia, Lin, Kimberly, Luo, Shiming, Hatipoglu, Dilara, Anand-Apte, Bela, Yuan, Alex]
通讯作者:
Yuan, Alex
Regulation of Choroidal Neovascularization in Sorsby's Fundus Dystrophy
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批准号:9900004
-
项目类别:
-
资助金额:$39.63万
-
财政年份:2017
-
负责人:BELA ANAND-APTE
-
依托单位:
FGF and hyaluronan-mediated alterations in epithelial-mesenchymal transition and metabolism of RPE cells in Sorsby Fundus Dystrophy.
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批准号:10408757
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项目类别:
-
资助金额:$62.17万
-
财政年份:2017
-
负责人:BELA ANAND-APTE
-
依托单位:
FGF and hyaluronan-mediated alterations in epithelial-mesenchymal transition and metabolism of RPE cells in Sorsby Fundus Dystrophy.
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批准号:10636830
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项目类别:
-
资助金额:$61.01万
-
财政年份:2017
-
负责人:BELA ANAND-APTE
-
依托单位:
Role of Retinoic Acid in the Regulation of the Blood-Retinal Barrier.
-
批准号:9769753
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项目类别:
-
资助金额:$41.3万
-
财政年份:2016
-
负责人:BELA ANAND-APTE
-
依托单位:
NEI CENTER CORE GRANT FOR VISION RESEARCH
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批准号:9336307
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项目类别:
-
资助金额:$63.4万
-
财政年份:2016
-
负责人:BELA ANAND-APTE
-
依托单位:
NEI Center Core Grant for Vision Research
-
批准号:10273076
-
项目类别:
-
资助金额:$64.4万
-
财政年份:2016
-
负责人:BELA ANAND-APTE
-
依托单位:
CORE A - Administrative Core
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批准号:10273077
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项目类别:
-
资助金额:$2.26万
-
财政年份:2016
-
负责人:BELA ANAND-APTE
-
依托单位:
NEI Center Core Grant for Vision Research
-
批准号:10670892
-
项目类别:
-
资助金额:$64.4万
-
财政年份:2016
-
负责人:BELA ANAND-APTE
-
依托单位:
Role of Retinoic Acid in the Regulation of the Blood-Retinal Barrier.
-
批准号:9334214
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项目类别:
-
资助金额:$41.3万
-
财政年份:2016
-
负责人:BELA ANAND-APTE
-
依托单位:
Cole Eye Institute Vision Science Training Program
-
批准号:10407662
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项目类别:
-
资助金额:$0.15万
-
财政年份:2015
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负责人:BELA ANAND-APTE
-
依托单位:
Cole Eye Institute Vision Science Training Program
-
批准号:10595051
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项目类别:
-
资助金额:$3.62万
-
财政年份:2015
-
负责人:BELA ANAND-APTE
-
依托单位:
Cole Eye Institute Vision Science Training Program
-
批准号:9027846
-
项目类别:
-
资助金额:$17.4万
-
财政年份:2015
-
负责人:BELA ANAND-APTE
-
依托单位:
Cole Eye Institute Vision Science Training Program
-
批准号:9262929
-
项目类别:
-
资助金额:$12.6万
-
财政年份:2015
-
负责人:BELA ANAND-APTE
-
依托单位:
Cole Eye Institute Vision Science Training Program
-
批准号:8855069
-
项目类别:
-
资助金额:$16.87万
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财政年份:2015
-
负责人:BELA ANAND-APTE
-
依托单位:
Role of betacellulin in diabetic macular edema
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批准号:8231532
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项目类别:
-
资助金额:$39.25万
-
财政年份:2011
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负责人:BELA ANAND-APTE
-
依托单位:
Role of betacellulin in diabetic macular edema
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批准号:8107705
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项目类别:
-
资助金额:$39.25万
-
财政年份:2011
-
负责人:BELA ANAND-APTE
-
依托单位:
Role of betacellulin in diabetic macular edema
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批准号:8449210
-
项目类别:
-
资助金额:$37.29万
-
财政年份:2011
-
负责人:BELA ANAND-APTE
-
依托单位:
Role of betacellulin in diabetic macular edema
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批准号:8657047
-
项目类别:
-
资助金额:$38.47万
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财政年份:2011
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负责人:BELA ANAND-APTE
-
依托单位:
CAN CD 133 CELLS PREVENT HYPOXIA DRIVEN RETINAL NEOVASCULARISATION IN A RODENT MO
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批准号:7405687
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项目类别:
-
资助金额:$31.06万
-
财政年份:2007
-
负责人:BELA ANAND-APTE
-
依托单位:
Inhibition of VEGF Mediated Angiogenesis by TIMP-3
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批准号:7112292
-
项目类别:
-
资助金额:$26.82万
-
财政年份:2005
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负责人:BELA ANAND-APTE
-
依托单位:
国内基金
海外基金
Ascl1介导Wnt/beta-catenin通路在TLE海马硬化中反应性Astrocytes异常增生的作用及调控机制
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批准号:31760279
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项目类别:地区科学基金项目
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资助金额:35.0万元
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批准年份:2017
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负责人:丁银秀
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依托单位: