Deep learning enabled, deep ultraviolet scanning microscopy for intraoperative assessment of margin status during breast cancer surgery

支持深度学习的深紫外扫描显微镜用于乳腺癌手术期间边缘状态的术中评估

基本信息

  • 批准号:
    10697381
  • 负责人:
  • 金额:
    $ 40.12万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-09-06 至 2026-05-31
  • 项目状态:
    未结题

项目摘要

Women with positive margins after breast-conserving surgery (BCS) have a 2-fold increased risk of cancer recurrence and are recommended to undergo additional re-excision surgery to achieve negative margins. Additional surgery is associated with significant emotional, cosmetic and financial burdens for patients and their caregivers. Although radiography, frozen section, touch prep and MarginProbe are available for intraoperative margin assessment, their accuracy is variable and most, except radiographic examination, are time- and labor- intensive and not routinely used. Since publication of the 2014 SSO-ASTRO guidelines for invasive cancer recommending re-excision for positive margins only, the re-excision rates have decreased but remain substantial (14-18%) with significant variation among surgeons. Because the size of BCS specimens varies significantly (a few to >40 cm2 per margin) and positive margins often include one or multiple sites/foci, a device with both variable margin coverage and microscopic resolution that can accurately evaluate an entire surgical specimen within a few minutes is highly desirable. While new technologies have been proposed, they are either point or high resolution devices with a very small field-of-view that requires excessive time to scan a specimen, or wide- field devices with low resolution and poor sensitivity. None has demonstrated the capability of analyzing an entire lumpectomy specimen with both adequate resolution and time efficiency in a clinical setting. Our goal is to develop a deep learning (DL) enabled, deep ultraviolet (DUV) scanning microscope (DDSM) for subcellular resolution and rapid (<5 min) examination of freshly excised tumor specimens during BCS. We hypothesize that there are significant subcellular optical contrasts that can be identified by the DDSM to differentiate breast cancer cells from normal tissue. Our preliminary DUV images demonstrate excellent contrasts and accuracy for identification of breast cancer cells. We propose that large and variable margin coverage, microscopic resolution and high speed are achieved by using: 1) DUV light for surface excitation of fresh specimens; 2) parallel imaging of two margins; 3) a low optical manification for fast speed; and 4) DL and sparse-sampling (SS) to rapidly search for pathological features of cancer cells. In Aim 1, a novel DDSM instrument will be developed and used to image 120 fresh breast tissues. DL classification algorithms will be developed and validated using the 120 tissue samples in Aim 2. Aim 3 will integrate DL and SS algorithms into the DDSM and demonstrate for fast detection of variable amount of cancer cells on the surfaces of breast tumor specimens. DDSM is highly innovative, combining DUV microscopy, parallel imaging, DL classification, and SS in a fast, compact, automated design. During initial BCS, if the DDSM accurately and efficiently identifies positive margins, additional breast tissue would be removed from the surgical cavity until negative margins are achieved and unnecessary removal of additional tissue would be avoided, thus decrease the need for additional surgery. DDSM is a platform technology that can be used with other imaging modalities or adapted for detection of other cancer or noncancer conditions.
保乳手术(BCS)后边缘呈阳性的妇女患癌症的风险增加了2倍

项目成果

期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Deep learning classification of deep ultraviolet fluorescence images toward intra-operative margin assessment in breast cancer.
  • DOI:
    10.3389/fonc.2023.1179025
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    4.7
  • 作者:
    To, Tyrell;Lu, Tongtong;Jorns, Julie M.;Patton, Mollie;Schmidt, Taly Gilat;Yen, Tina;Yu, Bing;Ye, Dong Hye
  • 通讯作者:
    Ye, Dong Hye
Analysis of Deep Ultraviolet Fluorescence Images for Intraoperative Breast Tumor Margin Assessment.
用于术中乳腺肿瘤边缘评估的深紫外荧光图像分析。
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Dong Hye Ye其他文献

Dong Hye Ye的其他文献

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{{ truncateString('Dong Hye Ye', 18)}}的其他基金

Deep learning enabled, deep ultraviolet scanning microscopy for intraoperative assessment of margin status during breast cancer surgery
支持深度学习的深紫外扫描显微镜用于乳腺癌手术期间边缘状态的术中评估
  • 批准号:
    10567960
  • 财政年份:
    2022
  • 资助金额:
    $ 40.12万
  • 项目类别:

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