Adult Changes in Thought (ACT) Research Program Core F: Data and Analysis Core

CORE F.数据和分析核心摘要 成人思想变化（ACT）U19研究计划旨在更好地了解大脑衰老， 影响认知结果和痴呆症的整个生命过程的因素。U19计划将 通过利用研究现有的丰富纵向数据和改进研究队列来实现这一目标 多样性、数据来源、科学和方法范围以及数据共享能力。U19将 通过三个研究项目回答新的重要科学问题，包括： 24小时活动模式与认知和功能老化之间的关系（项目1）; 在认知定义的阿尔茨海默病亚组中存在差异的因素，以更好地了解异质性 疾病及其影响（项目2）;以及评估普通药物 课程可能会影响大脑和认知（项目3）。为了使这项奋进可能，ACT U19计划包括六个资源核心。核心F：数据和分析核心是其中之一， 通过与所有其他核心和项目的接口来发挥作用。数据和分析核心的主要功能是帮助 ACT U19计划实现了三个目标：（1）管理一个安全、多域ACT存储库， 最高质量的临床、生物和电子健康记录数据;（2）提供全面的 提供生物统计和方案支持，以进行分析，回答感兴趣的科学问题， 开发方法并进行必要的创新，以解决项目的复杂性;（3）促进高效 与外部研究人员共享数据，以促进ACT U19数据的广泛使用，从而履行承诺， 这一独特的公共资助资源有助于增加对痴呆症的了解。的数据和分析 核心是围绕这三个职能组织起来的，它将自己分为一个信息学股，一个生物统计学股， 和数据共享单元。这些单位很适合担任这些角色，因为核心的成员 将能够利用他们广泛的生物统计领导经验，他们的科学知识， 痴呆症和阿尔茨海默病，他们的编程知识和对相关数据的深入了解， ACT，以及他们通过数据共享支持公共研究的承诺。雄心勃勃的 ACT U19计划的研究议程需要一个数据和分析核心团队，能够促进高， 完整的数据收集和复杂的分析框架，我们有信心 我们已经组建了一支能够应对这些挑战并指导ACT U19计划取得成功的团队。

CORE F. DATA AND ANALYSIS CORE ABSTRACT The Adult Changes in Thought (ACT) U19 Research Program aims to better understand brain aging and factors across the life course that influence cognitive outcomes and dementia. The ACT U19 Program will achieve this aim by leveraging the study’s existing rich longitudinal data and by improving the study’s cohort diversity, data sources, scientific and methodological scope, and capacity for data sharing. The ACT U19 will answer new important scientific questions through its three research Projects that involve: understanding relationships between 24-hour activity patterns and cognitive and functional aging (Project 1); assessment of factors that differ across cognitively defined Alzheimer’s disease subgroups to better understand heterogeneity in disease and its impacts (Project 2); and evaluation of the mechanisms by which common medication classes may impact the brain and cognition (Project 3). To make this research endeavor possible, the ACT U19 Program includes six resource Cores. Core F: Data and Analysis Core is one of these and plays a key role by interfacing with all other Cores and Projects. The Data and Analysis Core’s primary functions in helping the ACT U19 Program achieve its aims are three-fold: (1) manage a secure, multi-domain ACT Repository of clinical, biological, and electronic health record data that are of the highest quality; (2) provide comprehensive biostatistical and programmatic support to conduct analyses that answer the scientific questions of interest, developing methods and innovating as necessary to address project complexities; and (3) facilitate efficient data sharing with external researchers to promote broad use of ACT U19 data, thus upholding the promise that this unique, publicly-funded resource holds for increasing understanding of dementia. The Data and Analysis Core is organized around these three functions by structuring itself into an Informatics Unit, a Biostatistics Unit, and a Data Sharing Unit. These Units are well positioned for serving these roles because the Core’s members will be able to leverage their extensive biostatistical leadership experience, their scientific knowledge of dementia and Alzheimer’s disease, their programmatic know-how and deep knowledge of data relevant for ACT, and their demonstrated commitment to supporting public research through data sharing. The ambitious research agenda of the ACT U19 Program requires a Data and Analysis Core team capable of facilitating high- integrity data collection and sophisticated analytical frameworks that embrace complexity, and we are confident that we have assembled a team that can meet these challenges and guide the ACT U19 Program to success.