Building Interdisciplinary Research Careers in Women's Health

摘要 这是Vanderbilt-Meharry BIRCWH奖的补充，将支持第四位BIRCWH学者Ana博士 Serezani是一名拉丁裔，也是医学系的研究助理教授。她的研究 探讨适应性免疫反应和先天免疫反应在慢性肺部疾病中的作用。 对疾病病因学中的性别差异感兴趣。Serezani博士将扩大我们BIRCWH学者的多元化群体。 她得到了杰出的导师蒂莫西·布莱克韦尔博士和道恩·纽科姆博士的指导。Serezani博士是一位 非常适合我们的项目。她的工作涵盖了我们五个具有非凡机构实力的主题领域中的三个： 机制，性和性别生物学，以及精确医学研究。她加入了一个致力于 卓越的研究成果。项目环境为强大的机械性和治疗性创造了协同效应 研究提供实验室内外的发现。我们37位前任和现任学者进行了 各种研究包括狼疮的免疫学和遗传学方面，对阿尔茨海默氏症恢复力的性别差异， 性激素在哮喘发病和严重程度中T细胞分化和细胞因子表达中的作用。 学者中79%为女性，27%认同少数族裔、性取向或弱势群体 在研究中，地位历来被低估。几乎所有人都仍在研究中。在培训期间，学者们 平均每年出版8份出版物，校友获得107份校外补助金，价值超过5000万美元 合计。BIRCWH学者以女性健康和性别差异研究的基本原理为基础， 准备领导协作团队，接受培训以有效部署创新的跨学科方法 攻击和解决问题，并致力于研究，以优化所有妇女的健康。 学者是通过对早期职业教师的申请进行竞争性审查而选出的。培训是为 个人学者由结构化的跨学科导师指导，并由三名合作个人负责人监督，他们是 都是前BIRCWH学者。计划资源由无数机构资源进一步扩展，这些机构资源 确保我们的研究人员茁壮成长。学者们组成一个指导小组，参加每周一次的BIRCWH工作- 进步会议和研讨会，每年接受两次正式评估，每月参加两次职业生涯 与其他K奖获得者举办一系列发展研讨会，并定期接触负责任的案例研究 进行严谨和可重复的研究。他们可以访问：1)一系列核心；2)生物统计 咨询；3)稿件准备小组；4)成品的技术编辑；5)有专家的工作室 审查科学想法、目标和研究设计；6)校内试点资金；7)赠款撰写支持，包括 赠款讲习班、资助赠款图书馆和内部研究科；以及8)新的专家协商，以 设计完全个性化的培训计划，称为路径。我们部署评估工具以不断增强 我们的项目由一个咨询委员会和网站访问者监督。结合在一起，这确保了我们谨慎地 在像Serezani博士这样的下一代妇女健康研究人员中支持卓越和建立多样性。

ABSTRACT This supplement to the Vanderbilt-Meharry BIRCWH award will support a fourth BIRCWH Scholar, Dr. Ana Serezani, who is a Latina and a Research Assistant Professor in the Department of Medicine. Her research examines the contribution of adaptive and innate immune responses to chronic lung diseases, with a particular interest in sex differences in disease etiology. Dr. Serezani will expand our diverse group of BIRCWH scholars. She is being mentored by exceptional mentors Drs. Timothy Blackwell and Dawn Newcomb. Dr. Serezani is an ideal fit for our program. Her work spans three of our five thematic areas of exceptional institutional strength: mechanisms, sex and gender biology, and precision medicine research. She joins a cohort dedicated to research excellence. The program environment creates synergy for robust mechanistic and therapeutic research to deliver discoveries both inside and outside the lab. Our 37 former and current scholars conduct research as varied as immunologic and genetic aspects of lupus, sex differences in resilience to Alzheimer's, and role of sex hormones in T cell differentiation and cytokine expression in asthma onset and severity. Scholars are 79% women and 27% identify with minority race/ethnicity, sexual orientation, or disadvantaged status historically underrepresented in research. Nearly all remain in research. During training, scholars average 8 publications a year, and alumni have been awarded 107 extramural grants worth over $50 million total. BIRCWH Scholars are grounded in fundamentals of women's health and sex differences research, prepared to lead collaborative teams, trained to effectively deploy innovative interdisciplinary approaches to attack and solve problems, and committed to pursuing research that optimizes the health of all women. Scholars are selected by competitive review of applications from early career faculty. Training is tailored to the individual scholar guided by structured interdisciplinary mentorship and is overseen by a trio of Co-PIs who are all former BIRCWH Scholars. Program resources are further extended by myriad institutional resources that ensure our researchers thrive. Scholars form a mentoring panel, participate in weekly BIRCWH work-in- progress sessions and seminars, receive formal evaluation twice a year, attend twice-monthly career development seminar series with other K-awardees, and are regularly exposed to case studies on responsible conduct of rigorous and reproducible research. They have access to: 1) an array of cores; 2) biostatistics consults; 3) manuscript preparation groups; 4) technical editing of completed products; 5) studios with experts to vet scientific ideas, aims, and research designs; 6) intramural pilot funding; 7) grant writing support including grant workshops, a library of funded grants, and internal study sections; and 8) new expert consultations to design fully individualized training plans termed Pathways. We deploy evaluation tools to continuously enhance our program with oversight by an advisory committee and site visitors. Combined, this ensures we carefully support excellence and build diversity in the next generation of women's health researchers like Dr. Serezani.