Building Interdisciplinary Research Careers in Women's Health

计划摘要 范德比尔特BIRCWH学者计划的目标是增加准备充分的调查员队伍 致力于通过进步性和性别生物学来增进对女性健康的了解。我们的意图是 为了将性别/性别差异的研究整合到整个科学领域蓬勃发展的研究项目中， 以实现对女童和妇女的个性化预防、诊断和治疗。我们是 建立在包括大规模卫生系统数据在内的卓越研究传统的基础上；持续的队列， 有超过9万人参与的几个项目，如南方社区队列研究和上海妇女 和男性健康研究；20年的医疗补助数据记录联系；DNA样本与临床联系 220,000多名患者的数据；强大的组织和生物标志物银行和财团访问；以及 50个核心，支持跨学科团队在实验室内外进行基础性发现。我们的 25名前任和现任学者在狼疮的免疫学方面、性别等领域进行研究 女性和女性在ICU护理结果、步态和假体翻修需求方面的差异 男性截肢者，性激素在T细胞分化和细胞因子表达中的作用，以及 比较女性和男性痴呆症的进展和抵抗。我们所有的校友都留在理工科或 工业。在学者中，所有人都获得过校外奖项，88%是由联邦资金资助的，总共有更多 超过3200万美元的校外研究支持。BIRCWH学者的基础是 妇女健康和性别差异研究，准备领导协作团队，接受有效培训 部署创新的跨学科方法来应对和解决问题，并致力于 使女性的个性化护理更接近现实的研究。学者是由竞争对手选出的 对职业生涯初期教师的申请进行审查。培训是为个别学者量身定做的，由 有组织的跨学科指导，并由PI、计划主任和助理计划监督 主任(每名前BIRCWH学者)。学者们组成一个指导小组，制定个性化的职业计划， 每周参加BIRCWH正在进行的工作演示和研讨会，接受正式评估 每年参加两次职业发展研讨会，每月与其他K奖获得者一起参加，并定期 接触到关于负责任地进行严谨和可重复研究的案例研究。他们可以访问： 1)一系列岩芯；2)生物统计学咨询；3)手稿准备小组；4)技术编辑 完成的产品；5)有专家的工作室，以审查科学想法、目标和研究设计；6)内部 试点和可行性资金；以及7)赠款编写支助，包括赠款讲习班、一个有经费的赠款图书馆和 内部研究部分。有适当的工具来评估学员和导师，并不断提高 我们的节目。监督由一个咨询委员会和两年一次的外部审查提供。将这些组合在一起 努力确保我们能够继续培养优秀的下一代妇女健康研究人员。

PROGRAM SUMMARY The goal of the Vanderbilt BIRCWH Scholars Program is to increase the pool of well-prepared investigators dedicated to advancing knowledge about women's health via advances in sex and gender biology. Our intent is to integrate the study of sex/gender differences into thriving research programs across the scientific spectrum, in order to actualize personalized prevention, diagnostics, and therapeutics for girls and women. We are building on a tradition of research excellence that includes large-scale health system data; ongoing cohorts, several with more than 90,000 participants like the Southern Community Cohort Study and Shanghai Women's and Men's Health Studies; two decades of Medicaid data record linkages; DNA samples linked with clinical data for more than 220,000 patients; robust tissue and biomarker banks and consortia access; and more than 50 cores that support interdisciplinary teams making fundamental discoveries inside and outside the lab. Our 25 former and current scholars conduct research in areas as diverse as immunologic aspects of lupus, gender differences in outcomes of ICU care, differences in gait and needs for prosthetic revision among female and male amputees, role of sex hormones in T cell differentiation and cytokine expression, and patterns of progression and resistance to dementia comparing women and men. All our alumni remain in science or industry. Of those in academics, all have had extramural awards, 88% with federal funding, for a total of more than $32 million in extramural research support. BIRCWH Scholars are grounded in the fundamentals of women's health and sex differences research, prepared to lead collaborative teams, trained to effectively deploy innovative interdisciplinary approaches to attack and solve problems, and committed to pursuing research that brings individualized care for women closer to reality. Scholars are selected by competitive review of applications from among early-career faculty. Training is tailored to the individual scholar guided by structured interdisciplinary mentorship, and is overseen by the PI, Program Director and Associate Program Director (each former BIRCWH Scholars). Scholars form a mentoring panel, craft an individualized career plan, participate in weekly BIRCWH work-in-progress presentations and seminars, receive formal evaluation each year, attend twice-monthly career development seminar series with other K-awardees, and are regularly exposed to case studies on responsible conduct of rigorous and reproducible research. They have access to: 1) an array of cores; 2) biostatistics consults; 3) manuscript preparation groups; 4) technical editing of completed products; 5) studios with experts to vet scientific ideas, aims, and research designs; 6) intramural pilot and feasibility funding; and 7) grant writing support including grant workshops, a funded grant library, and internal study sections. Tools are in place to evaluate both mentees and mentors and to continuously enhance our program. Oversight is provided by an advisory committee and biennial external reviews. Combined these efforts ensure we can continue to foster excellence in the next generation of women's health researchers.