肥胖中味觉和嗅觉个体差异的机制-猫眼课题宝

肥胖中味觉和嗅觉个体差异的机制

批准号：

10699641

负责人：

Paule Joseph

金额：

$16.18万

依托单位：

NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

依托单位国家：

美国

项目类别：

财政年份：

资助国家：

美国

项目状态：

未结题

起止时间：

至

来源：

https://reporter.nih.gov/project-details/10699641

关键词：

Address Affect Age Americas Area Blood Data Analyses Diet Dietary Intervention Eating Eating Behavior Enrollment Food Fostering Hour Individual Inflammation Institutional Review Boards Intervention Investigation Lead Measures Neurons Non obese Obesity Outcome Measure Participant Plasma Prevention Public Health Risk Risk Factors Smell Perception System Taste Perception Time Unhealthy Diet United States National Institutes of Health Variant Visit Washington behavioral pharmacology chemokine clinical center cohort comorbidity cytokine design effective intervention exosome food consumption gut microbiota improved individual variation inflammatory marker metropolitan microbiome composition microbiota nasal microbiome negative affect novel obese person obesity development obesity treatment oral microbiome prevent primary outcome recruit screening secondary outcome sex success transcriptomics

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英文摘要

This IRB approved study involves comparison of taste and smell measures between obese and non-obese individuals. Taste and smell perceptions will be assessed in terms of their influence on food intake and food choices. We hypothesize that obesity negatively affects taste and smell perception thus affecting eating behavior. We will recruit a cohort of 124 obese individuals matched by age and sex with 124 healthy non-obese controls. Participants will be recruited from the Washington Metropolitan area and vicinity. This study will take place at the NIH Clinical Center. The study is expected to be completed in 60 months from opening of enrollment to study completion of data analysis. This study involves one screening visit and 2 study visits. The screening visit will last approximately 4-5 hours. Visits 1 and 2 will take approximately 4-6 hours each to complete. Currently enrolling

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