Mechanisms Underlying Individual Variations of Taste and Smell in Obesity

肥胖中味觉和嗅觉个体差异的机制

• 批准号: 10922439
• 负责人: Paule Joseph
• 金额: $ 26.71万
• 依托单位: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10922439
• 关键词: Address; Affect; Age; Area; Behavioral; Blood; Data Analyses; Diet; Dietary Intervention; Eating; Eating Behavior; Enrollment; Food; Fostering; Hour; Individual; Inflammation; Institutional Review Boards; Intervention; Investigation; Measures; Neurons; Non obese; Obesity; Outcome Measure; Participant; Plasma; Prevention; Public Health; Risk Factors; Risk Reduction; Smell Perception; System; Taste Perception; Time; Unhealthy Diet; United States National Institutes of Health; Variant; Visit; Washington; chemokine; clinical center; cohort; comorbidity; cytokine; design; effective intervention; exosome; food consumption; gut microbiota; improved; individual variation; inflammatory marker; metropolitan; microbiome composition; microbiota; nasal microbiome; negative affect; novel; obese person; obesity development; obesity treatment; oral microbiome; pharmacologic; prevent; primary outcome; recruit; screening; secondary outcome; sex; success; transcriptomics

This IRB-approved study compares taste and smell measures between obese and non-obese individuals. Taste and smell perceptions will be assessed regarding their influence on food intake and choices. We hypothesize that obesity negatively affects taste and smell perception, thus affecting eating behavior. We will recruit a cohort of 124 obese individuals matched by age and sex with 124 healthy non-obese controls. Participants will be recruited from the Washington Metropolitan area and vicinity. This study will take place at the NIH Clinical Center. The study is expected to be completed in 60 months from the opening of enrollment to study completion, including data analysis. This study involves one screening visit and 2 study visits. The screening visit will last approximately 4-5 hours. Visits 1 and 2 will take about 4-6 hours each to be compelted. Currently enrolling

这项经irb批准的研究比较了肥胖和非肥胖个体的味觉和嗅觉测量。将评估味觉和嗅觉对食物摄入和选择的影响。我们假设肥胖会对味觉和嗅觉产生负面影响，从而影响饮食行为。我们将招募124名按年龄和性别匹配的肥胖者和124名健康非肥胖者作为对照。参与者将从华盛顿大都会区及周边地区招募。这项研究将在美国国立卫生研究院临床中心进行。该研究预计将在60个月内完成，从入学开始到研究完成，包括数据分析。本研究包括一次筛选访问和两次研究访问。筛选访问将持续约4-5小时。参观1及2需时约4-6小时。

项目成果

Beliefs and willingness towards participating in genetic testing for depression in low-income and racial/ethnic minority mothers at-risk.

低收入和少数族裔母亲有风险参与抑郁症基因检测的信念和意愿。

• DOI: 10.1016/j.apnu.2022.07.002
• 发表时间: 2022
• 期刊: Archives of psychiatric nursing
• 影响因子: 2.3
• 作者: Atkins,Rahshida;Kelly,Terri-Ann;Johnson,Shanda;Deatrick,JanetA;Wunnenberg,Mary;Joseph,PauleV;Pudasainee-Kapri,Sangita;Gage,Gale;Pontes,NancyMH;Cresse,Nancy;Williams,Wanda
• 通讯作者: Williams,Wanda

Impact of depression and stress on placental DNA methylation in ethnically diverse pregnant women.

• DOI: 10.2217/epi-2021-0192
• 发表时间: 2021-09
• 期刊: Epigenomics
• 影响因子: 3.8
• 作者: M. Tesfaye;Suvo Chatterjee;Xuehuo Zeng;Paule Valery Joseph;F. Tekola-Ayele

SeqEnhDL: sequence-based classification of cell type-specific enhancers using deep learning models.

• DOI: 10.1186/s13104-021-05518-7
• 发表时间: 2021-03-19
• 期刊: BMC research notes
• 影响因子: 1.8
• 作者: Wang Y;Jaime-Lara RB;Roy A;Sun Y;Liu X;Joseph PV
• 通讯作者: Joseph PV

Association of inflammation biomarkers with food cravings and appetite changes across the menstrual cycle.

炎症生物标志物与整个月经周期的食物渴望和食欲变化的关联。

• DOI: 10.1016/j.clnesp.2023.06.004
• 发表时间: 2023
• 期刊: Clinical nutrition ESPEN
• 影响因子: 3
• 作者: Agarwal,Khushbu;Franks,AlexisT;Zhang,Xuemin;Schisterman,Enrique;Mumfordd,SunniL;Joseph,PauleV
• 通讯作者: Joseph,PauleV

Inflammatory Markers in Substance Use and Mood Disorders: A Neuroimaging Perspective.

• DOI: 10.3389/fpsyt.2022.863734
• 发表时间: 2022
• 期刊: FRONTIERS IN PSYCHIATRY
• 影响因子: 4.7
• 作者: Agarwal, Khushbu;Manza, Peter;Chapman, Marquis;Nawal, Nafisa;Biesecker, Erin;McPherson, Katherine;Dennis, Evan;Johnson, Allison;Volkow, Nora D.;Joseph, Paule V.
• 通讯作者: Joseph, Paule V.