Individual Variations of Taste and Smell Perception in Alcohol Use Disorder (AUD)

这项由机构审查委员会批准的研究比较了患有和没有AUD的个体之间的味觉和嗅觉测量以及酒精摄入量的测量。该研究计划招募264名AUD患者和132名非AUD患者。该校计划于2023年秋季开始招生。研究小组一直致力于完成3个关键领域的工作，以期招募第一个研究参与者，这些领域是开发临床操作和标准操作程序，设计数据收集工具和系统，并准备好研究用品和设备。所有业务和监管方面的考虑，包括员工培训，都在进行中。此外，研究小组一直在通过与NIH以外的第三方招聘专家合作制定招聘和保留计划。因此，已经设计了创新的、更有效的招聘和预筛选方法，并将在未来1-2个月内进行测试。

This Institutional Review Board-approved study compares taste and smell measures and measures of alcohol intake between individuals with and without AUD. The study plans to enroll 264 individuals with AUD and 132 individuals without AUD. Enrollment is planned to open in fall 2023. The study team has been working on finalizing 3 key areas in anticipation of enrolling the first research participant, these are develop clinic operations and SOPs, design data collection tools and systems, and make study supplies and equipment ready. All operational and regulatory considerations, including staff training, are underway. Moreover, the study team has been working on recruitment and retention plans through collaborating with third party recruitment experts outside the NIH. Consequently, innovative, and more efficient ways of recruitment and prescreening have been designed and will be tested in the next 1-2 months. This study will take place at the NIH clinical Center and is expected to be completed in 60 months from opening of enrollment. The study involves one screening visit and 2 study visits. Individuals will be screened under the NIAAA Natural History study, 14-AA-0181. Visits 1 and 2 will last approximately 4-6 hours.