J. NRSA Training Core

J.NRSA 培训核心

• 批准号: 10673896
• 负责人: OLAF S. ANDERSEN
• 金额: $ 66.83万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-05 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10673896
• 关键词: 26S proteasome; Adolescent; Adult; Appointment; Black race; Brain; COVID-19; Career Choice; Center for Translational Science Activities; Clinic; Clinical; Clinical Research; Clinical Sciences; Collaborations; Communities; Creativeness; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Detection; Development; Discipline; Disease; Education; Educational Curriculum; Educational workshop; Entrepreneurship; Environment; Exposure to; Faculty; Fellowship; Food; Foundations; Genomics; Goals; Health; Hippocampus; Hospitals; Human; Impaired cognition; Impairment; Industry; Inflammatory; Informatics; Inherited; Institution; Justice; Latino; Leadership; Learning; Medical Students; Medicine; Mentors; Metadata; Methodology; Minority-Serving Institution; Mus; National Research Service Awards; New York; Nurses; Obesity; Operative Surgical Procedures; Peripheral; Point Mutation; Postdoctoral Fellow; Presbyterian Church; Printing; Process; Pseudohermaphroditism; Research; Research Methodology; Resources; Safety; Science; Services; Signal Transduction; Societies; Stress; Students; TNFSF15 gene; Teacher Professional Development; Technology; Testing; Testosterone 5-alpha-Reductase; Training; Training Programs; Training and Education; Translational Research; Tuberculosis; Underrepresented Populations; Validation; Woman; biopharmaceutical industry; career; certificate program; clinical investigation; clinical training; clinical translation; diversity and inclusion; effectiveness measure; electronic data; exome sequencing; externship; faculty mentor; genome sequencing; graduate school; graduate student; gut microbiota; health equity; innovation; insertion/deletion mutation; interest; male; man; medical schools; medicine man; men; news; pre-doctoral; preadolescence; precision medicine; precision oncology; prevent; programs; recruit; response; sabbatical; skills; symposium; tau Proteins; trend; whole genome

Contact PD/PI: IMPERATO-MCGINLEY, JULIANNE L NRSA-Training-001 (244) J. TRAINING CORE (TL1) PROJECT SUMMARY/ ABSTRACT The fundamental goal of the Weill Cornell Clinical and Translational Science Center TL1 Training Core Program is to equip predoctoral and early postdoctoral trainees from diverse disciplines with the skills necessary to pursue transformative clinical and translational research before their career paths are established by offering distinct educational tracks culminating in advanced degrees that allow trainees to make an immediate impact in the clinic or in industry. The TL1 Training Program has trained highly successful predoctoral medical students, surgical residents and early graduate students, nurses and fellows recruited from all partner institutions. The TL1 trainees are fully integrated into CTSC activities and have access to all services provided by CTSC partners. Building on our successful training program developed over the last 14 years, we will introduce new courses, technologies and workshops geared towards team-based research, creativity, leadership, innovation, entrepreneurship, informatics, and precision medicine. The TL1 program offers a panoply of didactic programs available to TL1 Scholars including an Advanced Certificate in Clinical/Translational (C/T) Investigation intended for trainees who are interested in learning the fundamentals of Clinical and Translational Research; a Master’s Program in Clinical and Translational Investigation, the foundation of which is a Mentored Research Capstone Project in C/T research that is conducted in a team environment; an - MD/MS, program, a Summer Fellowship in C/T research; and innovative seminars, workshops, and courses offered throughout the year. Other groundbreaking training includes mentored research and externships/mini-sabbaticals with biopharmaceutical companies that will enrich trainees’ exposure to various career options in clinical and translational research. The diverse, highly skilled TL1 faculty and mentors are expertly trained to offer support for trainees throughout the program in order to help them pursue successful translational research careers. The CTSC has also established multiple collaborative resources to recruit and retain underrepresented populations. The enhanced TL1 will leverage the trainees to more rapidly advance in the field of Clinical and Translational Science. The planned duration of appointments is two years and, the projected number of trainees is 10 including 5 predoctoral, 5 postdoctoral trainees. Project Summary/Abstract Page 2570 Contact PD/PI: IMPERATO-MCGINLEY, JULIANNE L NRSA-Training-001 (244) REFERENCES: 1. Weill Cornell Medicine. Education & Training | Clinical & Translational Science Center, https://ctscweb.weill.cornell.edu/education-training (accessed June 22, 2021) 2. Advanced Certificate Program in Clinical & Translational Investigation | Clinical & Translational Science Center, https://ctscweb.weill.cornell.edu/education-training/programs/advanced-certificate-program-clinical- translational-investigation (accessed June 22, 2021) 3. Clinical Research Methodology Curriculum | Clinical & Translational Science Center, https://ctscweb.weill.cornell.edu/education-training/programs/clinical-research-methodology-curriculum (accessed June 22, 2021) 4. Cornell Cooperative Extension. Cornell Cooperative Extension | Serving communities in New York state and NYC, https://cals.cornell.edu/cornell-cooperative-extension (accessed June 22, 2021) 5. Imperato-McGinley J, Guerrero L, Gautier T, et al. Steroid 5alpha-reductase deficiency in man: an inherited form of male pseudohermaphroditism. Science 1974; 186: 1213–1215 6. Myeku N, Clelland CL, Emrani S, et al. Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling. Nat Med 2016; 22: 46–53 7. Wipperman MF, Bhattarai SK, Vorkas CK, et al. Gastrointestinal microbiota composition predicts peripheral inflammatory state during treatment of human tuberculosis. Nat Commun 2021; 12: 1141 8. Meyer HC, Odriozola P, Cohodes EM, et al. Ventral hippocampus interacts with prelimbic cortex during inhibition of threat response via learned safety in both mice and humans. Proc Natl Acad Sci USA. Epub ahead of print December 10, 2019. DOI: 10.1073/pnas.1910481116 9. Meyer HC, Gerhard DM, Amelio PA, et al. Pre-adolescent stress disrupts adult, but not adolescent, safety learning. Behav Brain Res 2021; 400: 113005 10. Weill Cornell Medicine. Englander Institute for Precision Medicine, https://eipm.weill.cornell.edu/ (accessed June 22, 2021) 11. Rennert H, Eng K, Zhang T, et al. Development and validation of a whole-exome sequencing test for simultaneous detection of point mutations, indels and copy-number alterations for precision cancer care. npj Genomic Med; 1. Epub ahead of print July 20, 2016. DOI: 10.1038/npjgenmed.2016.19 12. Weill Cornell Medicine, NewYork-Presbyterian Hospital and Illumina Collaborate on Scalable Clinical Whole-Genome Sequencing Initiative | Newsroom | Weill Cornell Medicine, https://news.weill.cornell.edu/news/2020/12/weill-cornell-medicine-newyork-presbyterian-hospital-and- illumina-collaborate-on (accessed June 22, 2021) 13. Harris PA, Taylor R, Thielke R, et al. Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inform 2009; 42: 377–381 14. NYC Health & Hospitals. Coler, https://www.nychealthandhospitals.org/coler/ (accessed June 22, 2021) 15. Overton J, Dickison M, Hootman K, Shukla A. Influences on Adolescent Food Decisions. Obesity November, 2020 28(S2):249 16. Berk RA, Berg J, Mortimer R, et al. Measuring the effectiveness of faculty mentoring relationships. Acad Med 2005; 80: 66–71 17. Gilmore-Bykovskyi A, Jackson JD, Wilkins CH. The Urgency of Justice in Research: Beyond COVID-19. Trends Mol Med. Epub ahead of print November 17, 2020. DOI: 10.1016/j.molmed.2020.11.004 18. Weill Cornell Medicine. Tri-Institutional Minority Society | Graduate School of Medical Sciences, https://gradschool.weill.cornell.edu/tri-institutional-minority-society (accessed June 22, 2021) 19. WCM Women In Medicine & Science | Office of Diversity and Inclusion, https://diversity.weill.cornell.edu/diverse-communities/women-medicine-science (accessed June 22, 2021) 20. SPARC Jr | Office of Diversity and Inclusion, https://diversity.weill.cornell.edu/student-diversity/enrichment- programs/sparc-jr (accessed June 22, 2021) 21. First Year of Diversity Faculty Development Mentoring Circles Program Completed | Weill Department of Medicine, https://medicine.weill.cornell.edu/news/first-year-diversity-faculty-development-mentoring-circles- program-completed (accessed June 22, 2021) 22. Black & Latino Men in Medicine Conference | Office of Diversity and Inclusion, https://diversity.weill.cornell.edu/communities/black-latino-men-medicine-conference (accessed June 22, 2021) 23. Diversity Mentoring Cascade | Cornell Center for Health Equity, https://centerforhealthequity.cornell.edu/education/diversity-center-of-excellence/diversity-mentoring- cascade/ (accessed June 22, 2021) References Cited Page 2571

联系PD/PI: IMPERATO-MCGINLEY， JULIANNE L NRSA-Training-001 （244）

项目成果

Simulation of preoperative flexion contracture in a computational model of total knee arthroplasty: Development and evaluation.

• DOI: 10.1016/j.jbiomech.2021.110367
• 发表时间: 2021-05-07
• 期刊: Journal of biomechanics
• 影响因子: 2.4
• 作者: Elmasry SS;Chalmers BP;Kahlenberg CA;Mayman DJ;Wright TM;Westrich GH;Cross MB;Sculco PK;Imhauser CW
• 通讯作者: Imhauser CW

Fluorinated Alcohols' Effects on Lipid Bilayer Properties.

氟化醇对脂质双层特性的影响。

• DOI: 10.1016/j.bpj.2018.07.010
• 发表时间: 2018
• 期刊: Biophysical journal
• 影响因子: 3.4
• 作者: Zhang,Mike;Peyear,Thasin;Patmanidis,Ilias;Greathouse,DeniseV;Marrink,SiewertJ;Andersen,OlafS;Ingólfsson,HelgiI
• 通讯作者: Ingólfsson,HelgiI

Regulation of social interaction in mice by a frontostriatal circuit modulated by established hierarchical relationships.

• DOI: 10.1038/s41467-023-37460-6
• 发表时间: 2023-04-29
• 期刊: NATURE COMMUNICATIONS
• 影响因子: 16.6
• 作者: Fetcho, Robert N.;Hall, Baila S.;Estrin, David J.;Walsh, Alexander P.;Schuette, Peter J.;Kaminsky, Jesse;Singh, Ashna;Roshgodal, Jacob;Bavley, Charlotte C.;Nadkarni, Viraj;Antigua, Susan;Huynh, Thu N.;Grosenick, Logan;Carthy, Camille;Komer, Lauren;Adhikari, Avishek;Lee, Francis S.;Rajadhyaksha, Anjali M.;Liston, Conor
• 通讯作者: Liston, Conor

Trends in clinical presentation of children with COVID-19: a systematic review of individual participant data.

• DOI: 10.1038/s41390-020-01161-3
• 发表时间: 2022-03
• 期刊: Pediatric research
• 影响因子: 3.6
• 作者: Christophers B;Gallo Marin B;Oliva R;Powell WT;Savage TJ;Michelow IC
• 通讯作者: Michelow IC

Characterization of mesenchymal stem cells and fibrochondrocytes in three-dimensional co-culture: analysis of cell shape, matrix production, and mechanical performance.

• DOI: 10.1186/s13287-016-0301-8
• 发表时间: 2016-03-12
• 期刊: Stem cell research & therapy
• 影响因子: 7.5
• 作者: McCorry MC;Puetzer JL;Bonassar LJ
• 通讯作者: Bonassar LJ