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The experience of human subjects with brain organoid research

人类受试者进行脑类器官研究的经验

基本信息

批准号：
10674018
负责人：
Kate E. MacDuffie
金额：
$ 24.52万
依托单位：
SEATTLE CHILDREN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-01 至 2025-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10674018
关键词：
3-Dimensional Acceleration Address Alzheimer&apos s Disease Animal Model Animals Attitude Award BRAIN initiative Back Basic Science Behavior Belief Belief System Bioethics Biological Brain Brain Diseases Cell Line Cell model Cells Child Childhood Clinical Clinical Data Code Communication Consent Forms DNA Data Data Collection Development Disease Education Environment Ethical Issues Ethics Faculty Family Family member Functional disorder Future Genes Goals Human Imaging Techniques In Vitro Individual Informed Consent Interview Joubert syndrome Kidney Knowledge Laboratories Learning Link Lung Master of Science Measures Mentors Modeling Modification Morals Nerve Degeneration Neurodegenerative Disorders Neurodevelopmental Disorder Neurosciences Neurosciences Research Organ Organoids Participant Pathology Patients Pattern Phase Play Policies Positioning Attribute Process Protocols documentation Registries Research Role Sampling Scientist Specimen Structure Surveys Technology Time Tissues Training Universities Washington autism spectrum disorder biobank brain based career clinical application efficacy testing experience human model human subject improved in vitro Model induced pluripotent stem cell innovation insight multidisciplinary nervous system disorder neural neural network neurodevelopment neuroethics neurotechnology non-invasive imaging patient engagement pilot test preference self organization skills sociodemographic factors sociodemographics stakeholder perspectives stem cells surrogate decision maker three-dimensional modeling working group

项目摘要

PROJECT SUMMARY Efforts to understand the mechanisms of brain-based disease have been hindered by the limited ability of animal models to reflect the full complexity of human brain and behavior. Brain organoids represent a potential solution, allowing scientists to model human neurodevelopmental and disease processes in-vitro. These multicellular, three-dimensional tissue structures are derived from induced pluripotent stem cells and self-organize to recapitulate aspects of human cortical development. Brain organoids are linked to their original human donor through shared DNA, and also through what they can reveal about individual-specific patterns of brain development and dysfunction. Given the central role the brain plays in personal identity, it is critical to understand what human donors think and feel about brain organoids grown from their cells, and consider whether organoid models of the brain deserve unique moral status compared to, for example, lung or kidney organoids. The proposed research seeks to engage participants and other stakeholders to explore ethical issues in brain organoid research, and thus addresses a core principle of BRAIN Initiative: considering the ethical implications of neuroscience research. In Aim 1, qualitative interviews with current participants will be conducted to explore their perspectives towards brain organoid research including beliefs about meaning, moral status, and permissible uses of organoid tissue. In Aim 2, an educational video that describes brain organoids will be imbedded into an online survey and used to measure attitudes in larger groups of stakeholders who represent future participants in brain organoid research. In Aim 3, insights learned from participants and stakeholders about preferences for brain organoid research will be compared to current research practices and modifications to guide the field going forward will be proposed. The long-term goal is to ensure that brain organoid research can achieve its scientific potential and proceed in accordance with donor beliefs and values. The proposed research and training plan will leverage expertise of an interdisciplinary team of mentors and strong bioethics/neuroethics research environment across the University of Washington Center for Neurotechnology and the Treuman Katz Center for Pediatric Bioethics at Seattle Children’s. During the mentored phase of the award, the applicant will gain new content knowledge in the basic science of brain organoids, learn new skills for neuroscience communication, and complete a master’s degree in bioethics. This additional training will equip the applicant with the skills necessary to conduct the proposed research and transition into an independent faculty position.

项目总结