Advanced in Vivo Cancer Models

先进的体内癌症模型

• 批准号: 10674541
• 负责人: Michael T. Lewis
• 金额: $ 23.28万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10674541
• 关键词: 3-Dimensional; Adoptive Cell Transfers; Animal Model; Area; Bioinformatics; Biological; Biology; CRISPR/Cas technology; Cancer Biology; Cancer Center; Cancer Center Support Grant; Cancer Model; Catchment Area; Cell Line; Cells; Charge; Chick; Chickens; Clinic; Clinical; Collaborations; Collection; Communities; Comprehensive Cancer Center; Credentialing; DNA; DNA sequencing; Data; Development; Disease; Embryo; Embryo Transfer; Emerging Technologies; Ensure; Equipment; Evaluation; Faculty; Fertilization in Vitro; Freezing; Funding; Generations; Genes; Genetic Engineering; Genetically Engineered Mouse; Genome; Hepatic; Human; Immune system; Immunocompromised Host; International; Invaded; Investigational Therapies; Knock-in; Knock-out; Lung; Maintenance; Malignant Neoplasms; Medicine; Methods; Microinjections; Modeling; Molecular; Mus; Mutation; Neoplasm Metastasis; Organoids; Patients; Pre-Clinical Model; Process; Proteomics; Protocols documentation; Reproducibility; Research Personnel; Resource Sharing; Resources; Science; Service delivery model; Services; Site; System; Techniques; Technology; Therapeutic Studies; Tissues; Transformed Cell Line; Transgenes; Transgenic Organisms; Translating; Treatment Efficacy; Validation; Work; Xenograft Model; angiogenesis; animal resource; anticancer research; cell immortalization; chicken egg; chimeric antigen receptor T cells; chorioallantoic membrane; college; computer infrastructure; conditional knockout; cost; cost effective; embryo cryopreservation; embryonic stem cell; exome; experimental study; gene replacement; genome editing; in vivo; in vivo Model; interest; metabolomics; mouse model; multiple omics; nuclease; patient derived xenograft model; preservation; rat genome; reconstitution; repository; response; sperm cryopreservation; tissue resource; transcriptome sequencing; tumor; tumor xenograft; whole genome

PROJECT SUMMARY: Advanced In Vivo Cancer Models (AICM) Shared Resource The Advanced In Vivo Cancer Models (AICM) Shared Resource of the Dan L Duncan Comprehensive Cancer Center (DLDCCC) is constructed to meet the needs of Cancer Center investigators wishing to use experimentally demanding, state-of-the-art, in vivo cancer models that require specialized techniques, and a high degree of experimental ingenuity. These models include genetically engineered mice (“knockout,” “knockin,” and transgenics), and patient-derived tumor xenografts (PDX) grown either in immunocompromised mice, or in alternative platforms such as the chicken egg chorioallantoic membrane (CAM). Both mouse and human-derived models require substantial validation work to “credential” that they are reflective of the biology of the disease or process under study. Since patient-derived tissues used to generate the models have considerable associated clinical and “omic” information, computational infrastructure is also required to abstract, store, organize, retrieve, and display such information so that investigators can make rational choices as to which model(s) to use, and to help interpret their results. The AICM Shared Resource will coordinate these activities for the Cancer Center to enhance in vivo model access, use, and utility in a cost-effective manner.

项目摘要：高级体内癌症模型（AICM）共享资源 Dan L Duncan综合癌症的先进体内癌症模型（AICM）共享资源 构建中心（DLDCCC）是为了满足希望使用的癌症中心调查人员的需求 实验要求的，最先进的体内癌症模型，需要专门的技术，A 高度的实验性。这些模型包括基因工程的小鼠（“敲除” 在免疫功能低下生长 小鼠，或在替代平台中，例如鸡蛋绒毛膜甲状腺膜（CAM）。鼠标和 人类衍生的模型需要大量验证工作才能“证明”它们反映生物学 正在研究的疾病或过程。由于用来生成模型的患者衍生组织具有 相当相关的临床和“ OMIC”信息，计算基础架构也需要 摘要，商店，组织，检索和显示此类信息，以便调查人员可以做出合理的选择 关于要使用哪种模型，并帮助解释其结果。 AICM共享资源将协调 这些活动为癌症中心增强体内模型的访问，使用和实用性，以具有成本效益 方式。