NEI UCI Center Core Grant for Vision Research

NEI UCI 中心视觉研究核心资助

• 批准号: 10676893
• 负责人: Vladimir Jivkov Kefalov
• 金额: $ 62.43万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2027-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10676893
• 关键词: Acceleration; Area; California; Cell Culture Techniques; Center Core Grants; Collaborations; Communities; Core Facility; Data; Educational process of instructing; Ensure; Equipment; Faculty Recruitment; Funding; Future; Health Services Accessibility; Human Resources; Image; Individual; Infrastructure; Institution; Laboratories; Maintenance; Mass Spectrum Analysis; Methods; Microanatomy; Ophthalmology; Postdoctoral Fellow; Productivity; Proteomics; Research; Research Methodology; Research Personnel; Research Project Grants; Research Support; Research Technics; Resources; Sampling; Scientist; Services; Stains; Structure; Students; Technical Expertise; Techniques; Testing; Time; Training; Universities; Use of New Techniques; Vision; Vision research; Voting; Work; career; catalyst; cost effectiveness; empowerment; improved; instrument; instrumentation; lipidomics; medical schools; mid-career faculty; new technology; ocular imaging; prevent; programs; recruit; research facility; research faculty; tool

ABSTRACT This P30 application seeks support for the Cores of Vision Research within the University of California Irvine (UCI) that will strengthen and enhance NEI R01-funded research. The project also aims to support the major expansion of vision research currently under way at UCI. It will broaden and optimize research capabilities, support and expand existing research projects, and help establish new studies, ultimately boosting productivity and strengthening vision research at UCI. Three research Core modules have been identified that would provide substantial benefit to current and future NEI R01-funded projects at UCI: (i). Ocular Microanatomy; (ii) Visual Function and Non-invasive Ocular Imaging; and (iii) Ocular Mass Spectrometry, Lipidomics, and Proteomics. In addition, an Administrative Group will be established to facilitate and support the function of these research Cores. The three research Cores were selected by majority votes of all current NEI R01-funded investigators, and other investigators who are directly or indirectly involved in ophthalmic research at UCI. The most requested services were developed into the Cores described in this P30 application. The vision research community at UCI has grown significantly over the past several years with the recruitment of 4 senior and 2 junior investigators and the formation of the Center for Translational Vision Research (CTVR), with at least two more mid-career faculty recruitments in the works. This expansion has been made possible by the exceptional institutional support from the Department of Ophthalmology and the School of Medicine, who have committed significant financial and infrastructure resources to bolster the vision research community at UCI. The services provided by the Cores for Vision Research will meet the scientific needs of the NEI R01-funded researchers as well as of early-stage investigators, and will increase efficiency, accelerate progress, and encourage new research directions and scientific collaborations at UCI. The Cores will also provide training and access to state-of-the-art experimental tools for students and postdoctoral scholars and will help prepare them for successful careers in ocular research.

抽象的 该P30应用程序寻求支持加利福尼亚大学视觉研究的支持 Irvine（UCI）将加强和增强NEI R01资助的研究。该项目还旨在支持 目前在UCI正在进行的视力研究的主要扩展。它将扩大和优化研究 能力，支持和扩展现有研究项目，并帮助建立新的研究 提高生产力并加强UCI的视力研究。三个研究核心模块已经 确定这将为UCI的当前和未来NEI R01资助的项目提供可观的好处：（i）。 眼微解剖； （ii）视觉功能和非侵入性眼成像； （iii）眼质量 光谱，脂质组学和蛋白质组学。此外，将建立一个行政小组 促进和支持这些研究核心的功能。这三个研究核心是由 当前所有由NEI R01资助的调查人员和其他直接或直接的调查人员的多数票 间接参与UCI的眼科研究。最要求的服务已发展到 该P30应用中描述的核心。 UCI的视觉研究界在 过去几年，招募了4名高级和2名初级调查员，并成立了 翻译视觉研究（CTVR），其中至少有两个中期的教师招募。 该部门的卓越机构支持使这一扩展成为可能 眼科和医学院，他们承诺了大量的财务和基础设施 加强UCI视觉研究社区的资源。核心提供的服务 研究将满足NEI R01资助的研究人员以及早期的科学需求 调查人员，并将提高效率，提高进度并鼓励新的研究方向 和UCI的科学合作。核心还将提供培训和最先进的访问 学生和博士后学者的实验工具，并将为成功的职业做好准备 在眼部研究中。

项目成果

A novel quantification method for retinal pigment epithelium phagocytosis using a very-long-chain polyunsaturated fatty acids-based strategy.

• DOI: 10.3389/fnmol.2023.1279457
• 发表时间: 2023
• 期刊: FRONTIERS IN MOLECULAR NEUROSCIENCE
• 影响因子: 4.8
• 作者: Gao, Fangyuan;Tom, Emily;Lieffrig, Stephanie A.;Finnemann, Silvia C.;Skowronska-Krawczyk, Dorota
• 通讯作者: Skowronska-Krawczyk, Dorota

Saving eyesight, one gene at a time.

• DOI: 10.1016/j.molmed.2023.04.008
• 发表时间: 2023-07
• 期刊: TRENDS IN MOLECULAR MEDICINE
• 影响因子: 13.6
• 作者: Holubowicz, Rafal;Palczewski, Krzysztof
• 通讯作者: Palczewski, Krzysztof