NEI UCI Center Core Grant for Vision Research

NEI UCI 中心视觉研究核心资助

• 批准号: 10676893
• 负责人: Vladimir Jivkov Kefalov
• 金额: $ 62.43万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2027-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10676893
• 关键词: Acceleration; Area; California; Cell Culture Techniques; Center Core Grants; Collaborations; Communities; Core Facility; Data; Educational process of instructing; Ensure; Equipment; Faculty Recruitment; Funding; Future; Health Services Accessibility; Human Resources; Image; Individual; Infrastructure; Institution; Laboratories; Maintenance; Mass Spectrum Analysis; Methods; Microanatomy; Ophthalmology; Postdoctoral Fellow; Productivity; Proteomics; Research; Research Methodology; Research Personnel; Research Project Grants; Research Support; Research Technics; Resources; Sampling; Scientist; Services; Stains; Structure; Students; Technical Expertise; Techniques; Testing; Time; Training; Universities; Use of New Techniques; Vision; Vision research; Voting; Work; career; catalyst; cost effectiveness; empowerment; improved; instrument; instrumentation; lipidomics; medical schools; mid-career faculty; new technology; ocular imaging; prevent; programs; recruit; research facility; research faculty; tool

ABSTRACT This P30 application seeks support for the Cores of Vision Research within the University of California Irvine (UCI) that will strengthen and enhance NEI R01-funded research. The project also aims to support the major expansion of vision research currently under way at UCI. It will broaden and optimize research capabilities, support and expand existing research projects, and help establish new studies, ultimately boosting productivity and strengthening vision research at UCI. Three research Core modules have been identified that would provide substantial benefit to current and future NEI R01-funded projects at UCI: (i). Ocular Microanatomy; (ii) Visual Function and Non-invasive Ocular Imaging; and (iii) Ocular Mass Spectrometry, Lipidomics, and Proteomics. In addition, an Administrative Group will be established to facilitate and support the function of these research Cores. The three research Cores were selected by majority votes of all current NEI R01-funded investigators, and other investigators who are directly or indirectly involved in ophthalmic research at UCI. The most requested services were developed into the Cores described in this P30 application. The vision research community at UCI has grown significantly over the past several years with the recruitment of 4 senior and 2 junior investigators and the formation of the Center for Translational Vision Research (CTVR), with at least two more mid-career faculty recruitments in the works. This expansion has been made possible by the exceptional institutional support from the Department of Ophthalmology and the School of Medicine, who have committed significant financial and infrastructure resources to bolster the vision research community at UCI. The services provided by the Cores for Vision Research will meet the scientific needs of the NEI R01-funded researchers as well as of early-stage investigators, and will increase efficiency, accelerate progress, and encourage new research directions and scientific collaborations at UCI. The Cores will also provide training and access to state-of-the-art experimental tools for students and postdoctoral scholars and will help prepare them for successful careers in ocular research.

摘要 此P30应用程序寻求对加州大学视觉研究核心的支持 欧文大学（UCI）将加强和提高NEI R 01资助的研究。该项目还旨在支持 UCI目前正在进行的视觉研究的主要扩展。它将拓宽和优化研究 能力，支持和扩大现有的研究项目，并帮助建立新的研究，最终 提高生产力，加强UCI的视觉研究。三个研究核心模块已被 确定将为UCI当前和未来的NEI R 01资助项目提供实质性利益：（i）。 眼部显微解剖学;（ii）视觉功能和非侵入性眼部成像;以及（iii）眼部肿块 光谱学、脂质组学和蛋白质组学。此外，将设立一个行政小组， 促进和支持这些研究中心的运作。这三个研究核心是由 所有当前NEI R 01资助的研究者的多数票，以及直接或 间接参与了UCI的眼科研究。要求最多的服务已发展成为 本P30申请中描述的核心。UCI的视觉研究社区在2008年以来显着增长， 在过去几年中，招聘了4名高级调查员和2名初级调查员，并成立了 翻译视觉研究（CTVR），至少有两个以上的职业生涯中期教师招聘的作品。 这一扩展之所以能够实现，是因为该部提供了特殊的机构支助， 眼科和医学院，谁承诺了重大的财政和基础设施 资源，以支持在UCI的视觉研究社区。由Cores for Vision提供的服务 研究将满足NEI R 01资助的研究人员以及早期阶段的科学需求 研究人员，并将提高效率，加快进展，并鼓励新的研究方向， 和科学合作。核心小组还将提供培训， 为学生和博士后学者提供实验工具，并将帮助他们为成功的职业生涯做好准备 在眼科研究中。

项目成果

A novel quantification method for retinal pigment epithelium phagocytosis using a very-long-chain polyunsaturated fatty acids-based strategy.

一种新型的定量方法，用于使用非常长的链多不饱和脂肪酸的策略，用于视网膜色素上皮细胞增多症。

• DOI: 10.3389/fnmol.2023.1279457
• 发表时间: 2023
• 期刊: FRONTIERS IN MOLECULAR NEUROSCIENCE
• 影响因子: 4.8
• 作者: Gao, Fangyuan;Tom, Emily;Lieffrig, Stephanie A.;Finnemann, Silvia C.;Skowronska-Krawczyk, Dorota
• 通讯作者: Skowronska-Krawczyk, Dorota

Saving eyesight, one gene at a time.

• DOI: 10.1016/j.molmed.2023.04.008
• 发表时间: 2023-07
• 期刊: TRENDS IN MOLECULAR MEDICINE
• 影响因子: 13.6
• 作者: Holubowicz, Rafal;Palczewski, Krzysztof
• 通讯作者: Palczewski, Krzysztof