High-Resolution Whole Heart Quantitative CMR Perfusion Imaging in Ischemic Heart Disease
缺血性心脏病的高分辨率全心定量 CMR 灌注成像
基本信息
- 批准号:10585807
- 负责人:
- 金额:$ 69.42万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-02-01 至 2025-01-31
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
7. Project Summary
As greater than 8 million Americans suffer from angina due to obstructive coronary artery disease (CAD) or
microvascular disease (MVD), which are both associated with an increased risk for adverse cardiovascular
events, accurate non-invasive assessment of the presence and functional significance of obstructive CAD and
evaluation of MVD is of substantial clinical importance. While both CAD and MVD are characterized by
abnormal coronary flow reserve (CFR), this parameter alone is insufficient to distinguish between these two
conditions which have different management strategies. High-resolution whole-heart quantitative adenosine
stress cardiac magnetic resonance (CMR) has the potential to provide a new tool to differentiate between
these entities based on its ability to quantify differences between endocardial and epicardial perfusion.
However, 3D quantitative adenosine stress CMR still suffers from a number of important limitations including
limited spatial coverage, low in-plane spatial resolution, long temporal acquisition windows, and sensitivity to
cardiac and respiratory motion. We have been developing efficient high-resolution 2D spiral CMR perfusion
pulse sequences to overcome these limitations while providing whole-heart coverage.
The broad long-term objective of this project is to develop robust high-resolution quantitative CMR perfusion
techniques with whole-heart coverage to understand the development of perfusion abnormalities in animal
models of microvascular disease and obstructive CAD, and to utilize these CMR techniques to improve the
non-invasive diagnosis and risk stratification of patients with CAD and MVD. Improved diagnostic techniques
for assessing myocardial perfusion in CAD and MVD could significantly reduce the need for invasive coronary
angiography among patients being evaluated for angina.
The specific aims for this project are: (1) To develop an efficient high-resolution 2D spiral-based perfusion
technique for robust, motion-insensitive and accurate measurements of myocardial perfusion and endocardial
to epicardial (endo:ep) perfusion ratio. (2) To test the hypothesis that CMR accurately measures endo:epi
perfusion ratios and detects a lower endo:epi ratio in obstructive CAD as compared to MVD in a porcine model.
(3) To develop an algorithm using CMR derived MPR and endo:epi perfusion ratios to differentiate CAD from
MVD in patients presenting with angina and known or suspected CAD.
Successful completion of this project will result in an efficient, robust, and well-validated technique for high-
resolution whole-heart quantification of myocardial perfusion able to accurately detect endo:epi perfusion
gradients, quantify MPR and myocardial ischemic burden, and differentiate obstructive CAD from MVD. The
very short temporal footprint and motion-insensitive reconstruction will enable robust perfusion quantification in
patients with increased heart rates and inability to perform breath-holding extending the applicability of CMR.
7.项目摘要
超过800万美国人因阻塞性冠状动脉疾病(CAD)或
微血管疾病(MVD),两者均与不良心血管疾病风险增加相关。
事件,准确无创评估阻塞性CAD的存在和功能意义,
MVD的评估具有重要的临床意义。虽然CAD和MVD的特征在于
冠状动脉血流储备(CFR)异常,仅此参数不足以区分这两者
有不同的管理策略。高分辨率全心定量腺苷
负荷心脏磁共振(CMR)有可能提供一种新的工具,以区分
这些实体基于其量化心内膜和心外膜灌注之间差异的能力。
然而,3D定量腺苷应激CMR仍然受到许多重要限制,包括
有限的空间覆盖范围、低平面内空间分辨率、长时间采集窗口以及对
心脏和呼吸运动。我们一直在开发高效的高分辨率2D螺旋CMR灌注
脉冲序列,以克服这些限制,同时提供全心脏覆盖。
该项目的广泛长期目标是开发强大的高分辨率定量CMR灌注
全心脏覆盖技术,以了解动物灌注异常的发展
微血管疾病和阻塞性CAD模型,并利用这些CMR技术来改善
CAD和MVD患者的无创诊断和风险分层。改进诊断技术
用于评估CAD和MVD中的心肌灌注可以显著减少对侵入性冠状动脉造影的需求。
正在评估心绞痛患者的血管造影。
本课题的具体目标是:(1)开发一种高效的高分辨率二维螺旋灌注成像系统
用于心肌灌注和内皮素的稳健、运动不敏感和精确测量的技术
与心外膜(endo:ep)灌注比。(2)检验CMR准确测量endo:epi的假设
与猪模型中的MVD相比,在阻塞性CAD中检测到更低的endo:epi比率。
(3)开发一种算法,使用CMR导出的MPR和Endo:Epi灌注比区分CAD和
心绞痛和已知或疑似CAD患者的MVD。
该项目的成功完成将导致一个高效,强大,以及验证技术的高,
能够准确检测Endo:EPI灌注的心肌灌注的分辨率全心脏量化
梯度,量化MPR和心肌缺血负荷,并区分梗阻性CAD与MVD。的
非常短的时间足迹和运动不敏感的重建将使鲁棒的灌注量化,
心率增加和无法屏气的患者,扩展了CMR的适用性。
项目成果
期刊论文数量(10)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(1)
DEep learning-based rapid Spiral Image REconstruction (DESIRE) for high-resolution spiral first-pass myocardial perfusion imaging.
基于深度学习的快速螺旋图像重建(DESIRE),用于高分辨率螺旋首过心肌灌注成像。
- DOI:10.1002/nbm.4661
- 发表时间:2022
- 期刊:
- 影响因子:2.9
- 作者:Wang,Junyu;Weller,DanielS;Kramer,ChristopherM;Salerno,Michael
- 通讯作者:Salerno,Michael
Adenosine stress CMR perfusion imaging of the temporal evolution of perfusion defects in a porcine model of progressive obstructive coronary artery occlusion.
腺苷应激 CMR 灌注成像显示渐进性阻塞性冠状动脉闭塞猪模型中灌注缺陷的时间演变。
- DOI:10.1002/nbm.4136
- 发表时间:2019
- 期刊:
- 影响因子:2.9
- 作者:VanHouten,M;Yang,Y;Hauser,A;Glover,DK;Gan,L-M;Yeager,M;Salerno,M
- 通讯作者:Salerno,M
Diagnostic Performance of Extracellular Volume, Native T1, and T2 Mapping Versus Lake Louise Criteria by Cardiac Magnetic Resonance for Detection of Acute Myocarditis: A Meta-Analysis.
通过心脏磁共振检测急性心肌炎的细胞外体积,天然T1和T2映射与路易丝湖标准的诊断性能:一项荟萃分析。
- DOI:10.1161/circimaging.118.007598
- 发表时间:2018-07
- 期刊:
- 影响因子:0
- 作者:Pan JA;Lee YJ;Salerno M
- 通讯作者:Salerno M
Content-aware compressive magnetic resonance image reconstruction.
- DOI:10.1016/j.mri.2018.06.008
- 发表时间:2018-10
- 期刊:
- 影响因子:2.5
- 作者:Weller DS;Salerno M;Meyer CH
- 通讯作者:Meyer CH
Inline Quantitative Myocardial Perfusion by CMR: Coming Online Soon?
CMR 在线定量心肌灌注:即将上线?
- DOI:10.1016/j.jcmg.2019.06.011
- 发表时间:2019
- 期刊:
- 影响因子:0
- 作者:Salerno,Michael
- 通讯作者:Salerno,Michael
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Michael Salerno其他文献
Michael Salerno的其他文献
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{{ truncateString('Michael Salerno', 18)}}的其他基金
Rapid Free-Breathing Self-Gated Spiral Pulse Sequences for Simultaneous Cine and T1 mapping
用于同步电影和 T1 映射的快速自由呼吸自选通螺旋脉冲序列
- 批准号:
10397984 - 财政年份:2021
- 资助金额:
$ 69.42万 - 项目类别:
Rapid Free-Breathing Self-Gated Spiral Pulse Sequences for Simultaneous Cine and T1 mapping
用于同步电影和 T1 映射的快速自由呼吸自选通螺旋脉冲序列
- 批准号:
10677550 - 财政年份:2021
- 资助金额:
$ 69.42万 - 项目类别:
Generalizing Deep Learning Reconstruction for Free-Breathing and Quantitative MRI
推广自由呼吸和定量 MRI 的深度学习重建
- 批准号:
10007241 - 财政年份:2019
- 资助金额:
$ 69.42万 - 项目类别:
High-Resolution Whole Heart Quantitative CMR Perfusion Imaging in Ischemic Heart Disease
缺血性心脏病的高分辨率全心定量 CMR 灌注成像
- 批准号:
9240289 - 财政年份:2017
- 资助金额:
$ 69.42万 - 项目类别:
Quantitative Adenosine Stress CMR with Spiral Pulse Sequences
螺旋脉冲序列定量腺苷应激 CMR
- 批准号:
8879192 - 财政年份:2012
- 资助金额:
$ 69.42万 - 项目类别:
Quantitative Adenosine Stress CMR with Spiral Pulse Sequences
螺旋脉冲序列定量腺苷应激 CMR
- 批准号:
8466371 - 财政年份:2012
- 资助金额:
$ 69.42万 - 项目类别:
Quantitative Adenosine Stress CMR with Spiral Pulse Sequences
螺旋脉冲序列定量腺苷应激 CMR
- 批准号:
8279056 - 财政年份:2012
- 资助金额:
$ 69.42万 - 项目类别:
Quantitative Adenosine Stress CMR with Spiral Pulse Sequences
螺旋脉冲序列定量腺苷应激 CMR
- 批准号:
8700494 - 财政年份:2012
- 资助金额:
$ 69.42万 - 项目类别:
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