Aspen Lung Conference: Asthma: Pathogenesis, Phenotypes, Therapies and Gaps

阿斯彭肺部会议：哮喘：发病机制、表型、治疗方法和差距

• 批准号: 10680832
• 负责人: ANTHONY N GERBER
• 金额: $ 3万
• 依托单位: NATIONAL JEWISH HEALTH
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-01 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10680832
• 关键词: Address; Asthma; Award; Basic Science; Biology; Cells; Cellular biology; Clinical; Clinical Research; Dedications; Development; Discipline; Disease; Environmental Impact; Environmental Risk Factor; Ethnic Population; Exposure to; Future; Generations; Genetic; Grant; Immune; Immune system; Immunology; Infectious Agent; International; Knowledge; Lung; Lung diseases; Measures; Mentorship; Minority; Molecular; Oral; Pathogenesis; Patients; Phenotype; Prevalence; Productivity; Publishing; Research; Research Personnel; Role; Scientific Advances and Accomplishments; Scientist; Series; Therapeutic; Translating; Translational Research; Translations; Travel; Underrepresented Minority; Woman; career; cell type; diversity and inclusion; early-career faculty; effective therapy; improved; interest; lectures; lung health; microbiome; molecular phenotype; novel strategies; posters; pre-clinical; programs; public health relevance; racial population; success; symposium

PROJECT SUMMARY/ABSTRACT With an emphasis on the integration of basic, translational, and clinical approaches, the 65th annual Aspen Lung Conference will focus on a central question: how can knowledge of the molecular, genetic, and environmental mechanisms that underlie the development and phenotypic diversity of asthma be translated into more effective therapies? To address this central question, the program is organized into a series of thematic sessions, with State of the Art speakers framing each topic. The thematic sessions will focus on (i) the developmental origins of asthma, (ii) the role of cell biology in defining asthma endotypes, (iii) microbiome and immune mechanisms underlying asthma pathogenesis, (iv) integrated cell and molecular mechanisms contributing to the clinical complexity of asthma, and (v) the future of asthma therapeutics. By addressing these topics, we seek to accomplish the following: 1) provide an international forum for leading basic, translational, and clinical researchers to exchange ideas regarding the development and cell type specific roles of the airway and immune system in the phenotypic and molecular manifestations of asthma; 2) stimulate interactions between scientific fields to identify emerging and shared interests that may lead to more efficient and productive research; 3) enhance the likelihood of success in translation of preclinical scientific advances into direct patient benefit by developing novel strategies to better understand disease pathogenesis and implement scientific advances in the treatment of asthma; and 4) challenge and stimulate the scientific interests of trainees and attract a new generation of early career investigators into the broad field of asthma, as well as underlying subdisciplines including airway and lung immune cell biology, genetics, and environmental impacts. We have identified 12 outstanding thought leaders to present State of the Art lectures (35 min) on these topics. Each presentation will be followed by 25 minutes of discussion - a hallmark of the Conference. The program continues the Aspen Lung Conference’s dedication to diversity and inclusivity: n=8/13 (62%) of State of the Art speakers/Summarizer are women, and at least 6 of our speakers are from underrepresented racial/ethnic groups. Participation of trainees and early career faculty is facilitated by two 15-minute oral abstracts, selected from submitted abstracts, following each State of the Art speaker (24 total). There will be two evening poster sessions for further presentation opportunities by early career faculty and trainees. The final presentation is provided by a Conference Summarizer, who reviews the impact and common themes of the Conference. The Conference Summary will be published for widespread dissemination, to serve as a “think tank” that not only summarizes the current state of the field, but also identifies key future directions for basic, translational, and clinical asthma research. Finally, and notably, registration for the Aspen Lung Conference is free, encouraging participation from a wide spectrum of trainees and early career investigators.

项目总结/摘要 第65届年度白杨肺学会强调基础、转化和临床方法的整合， 会议将集中讨论一个中心问题：如何将分子、遗传和 哮喘的发展和表型多样性的环境机制是 转化为更有效的治疗方法为了解决这个中心问题，该计划被组织成一个 一系列主题会议，由最新技术的发言者为每个主题提供框架。专题会议将侧重于 关于（i）哮喘的发育起源，（ii）细胞生物学在定义哮喘内型中的作用，（iii） 哮喘发病机制的微生物组和免疫机制，（iv）整合的细胞和分子 导致哮喘临床复杂性的机制，以及（v）哮喘治疗的未来。通过 针对这些主题，我们寻求实现以下目标：1）提供一个国际论坛， 翻译和临床研究人员就发展和细胞类型的具体作用交换意见 在哮喘的表型和分子表现中气道和免疫系统的作用; 2）刺激 科学领域之间的互动，以确定新出现的共同利益， 和生产性研究; 3）提高临床前科学进展转化为 通过开发新的策略来更好地了解疾病的发病机制， 哮喘治疗的科学进展;以及4）挑战和激发学员的科学兴趣 并吸引新一代的早期职业调查人员进入哮喘的广泛领域，以及潜在的 包括气道和肺免疫细胞生物学，遗传学和环境影响的子学科。我们有 确定了12位杰出的思想领袖，就这些主题进行最新技术讲座（35分钟）。每个 发言之后将进行25分钟的讨论-这是会议的一个特点。程序继续 白杨肺脏会议致力于多样性和包容性：n=8/13（62%）的最新技术水平 演讲者/总结者是女性，至少有6位演讲者来自代表性不足的种族/民族 组学员和早期职业教师的参与是由两个15分钟的口头摘要，选择 从提交的摘要中，在每位最新技术演讲者（共24位）之后。将有两个晚上的海报 会议为进一步介绍机会，由早期职业教师和学员。最后的介绍是 由会议总结员提供，他审查会议的影响和共同主题。的 会议摘要将出版广泛传播，作为一个“智囊团”，不仅 总结了该领域的现状，但也确定了基础，翻译和 临床哮喘研究最后，值得注意的是，白杨肺部会议的注册是免费的，令人鼓舞 广泛的受训人员和早期职业调查人员的参与。