Midcareer Investigator Patient-oriented Research Award in Bronchiolitis & Asthma

职业生涯中期研究员毛细支气管炎患者导向研究奖

• 批准号: 7451393
• 负责人: Tina V Hartert
• 金额: $ 15.91万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-03-15 至 2013-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7451393
• 关键词: Adult; Asthma; Award; Bronchiolitis; Causations; Child; Childhood; Childhood Asthma; Clinical; Clinical Research; Development; Disease; Environment; Environmental Risk Factor; Etiology; Genes; Genetic; Goals; Incidence; Infant; Infection; Intervention; Lower Respiratory Tract Infection; Mentors; Midcareer Investigator Award in Patient-Oriented Research; Natural History; Persons; Predisposition; Preventive; Recurrence; Research Activity; Research Project Grants; Resistance; Respiratory Tract Infections; Respiratory syncytial virus; Rhinovirus; Risk; Risk Factors; Role; Severities; Thinking; Time; Translating; Variant; Viral; Virus; Virus Diseases; Wheezing; career; design; disorder prevention; functional outcomes; infancy; pathogen; respiratory

DESCRIPTION (provided by applicant): Immediate Goals: To determine the role of environmental and genetic factors on the development of both bronchiolitis and asthma, with the goal of designing and implementing more effective preventive therapies to reduce the incidence and severity of both infant viral infections and childhood asthma. Career Development Goals: To provide sufficient time for mentoring and research activities. Research Project: Asthma is thought to result from host (genetic) and environment interactions. Viral infections are one important, and modifiable environmental factor that have been established to be important causes of asthma exacerbations in both children and adults; lower respiratory tract infections (LRTI), caused by viruses such as respiratory syncytial virus (RSV) and rhinovirus (RV), are a leading cause of bronchiolitis in infants. Infants hospitalized with bronchiolitis are at significantly increased risk for both recurrent wheezing and childhood asthma. It is not known whether viral respiratory infections directly contribute to asthma causation or simply identify persons at risk for subsequent wheezing. Thus, many possible determinants exist that may contribute to the severity of bronchiolitis and the subsequent development of asthma. This proposal uses a combined, parallel clinical and experimental approach to evaluate the contribution of, causality, and mechanism of how viruses contribute to asthma causation and natural history, all relating to the central hypothesis that viruses, as one significant environmental factor, alter the risk for developing asthma, as well as the natural history of prevalent disease. Specific testable questions related to this hypothesis include: 1) the respiratory viral pathogen, environmental factors, and timing of infection during infancy impact the risk of developing childhood asthma; 2) lower respiratory viral infection during infancy, and the severity of that infection correlates with an increased risk of childhood asthma; 3) allelic variations at genes involved with severity of respiratory viral infection will correlate with a predisposition or resistance to both infant bronchiolitis and childhood asthma. The aims of the mentored award will be met by allowing the PI to translate her experimental expertise to direct clinical studies of progression and functional outcome of childhood viral illness and asthma, with the next goal to make the transition from risk factor determination to intervention and disease prevention.

描述(由申请人提供)：近期目标：确定环境和遗传因素在毛细支气管炎和哮喘发展中的作用，目的是设计和实施更有效的预防性治疗，以降低婴儿病毒感染和儿童哮喘的发病率和严重程度。 职业发展目标：为指导和研究活动提供充足的时间。 研究项目：哮喘被认为是宿主(遗传)和环境相互作用的结果。病毒式传播 感染是一个重要的、可改变的环境因素，已被确定为儿童和成人哮喘恶化的重要原因；由呼吸道合胞病毒(RSV)和鼻病毒(RV)等病毒引起的下呼吸道感染(LRTI)是婴儿毛细支气管炎的主要原因。因毛细支气管炎住院的婴儿患反复喘息和儿童哮喘的风险显著增加。目前尚不清楚病毒呼吸道感染是直接导致哮喘的原因，还是只是确定有可能随后出现喘息的人。因此，存在许多可能的决定因素，这些因素可能导致毛细支气管炎的严重程度和随后的哮喘发展。这项建议采用临床和实验相结合的方法，评估病毒对哮喘病因和自然病史的贡献、因果关系和机制，所有这些都与一个中心假设有关，即病毒作为一个重要的环境因素，改变了哮喘的发病风险，以及流行疾病的自然病史。与这一假设相关的具体可检验问题包括：1)婴儿期呼吸道病毒病原体、环境因素和感染时间影响儿童哮喘的发病风险；2)婴儿期下呼吸道病毒感染，且感染的严重程度与儿童哮喘风险增加相关；3)与呼吸道病毒感染严重程度相关的基因的等位基因变异将与婴儿毛细支气管炎和儿童哮喘的易感性或抵抗力相关。 导师奖的目标将通过允许PI将她的实验专业知识转化为指导儿童病毒性疾病和哮喘的进展和功能结果的临床研究来实现，下一个目标是从风险因素确定过渡到干预和疾病预防。