Multi-Disciplinary Training Program in Translational Cardiovascular Research

转化心血管研究的多学科培训计划

• 批准号: 10117092
• 负责人: William Gregory Hundley
• 金额: $ 36.91万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-03-01 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10117092
• 关键词: Cardiovascular system; Research; Training Programs; multidisciplinary

This program is designed to train post-doctoral physicians and scientists capable of developing new advances in multi-disciplinary translational cardiovascular research directed toward the diagnosis, treatment and prevention of cardiovascular disease (CVD). Worldwide, CVD is the primary cause of morbidity and mortality for those >30 years in age; unfortunately in the US after years of decline, rates of CVD are now increasing in prevalence. This program will help to address the inadequate number of MD and PhD investigators (a shortage recognized by the NHLBI task force review of research training and career development programs) trained in multi-disciplinary CVD research activities that are needed to pursue solutions to reduce the burden of CVD. Our 5-year proposal includes the training of 4 MD applicants for 2 years beginning at the PGY 5 level, and 3 PhD applicants for 3 years beginning at the PGY 0 level. The program builds on research strengths at Virginia Commonwealth University (VCU) involving basic and clinical translational CV science using cellular, small animal, and single and multi-center population cohort and clinical trials. Key features of this proposed T32 training program include: 1) pairing each trainee with an externally funded research mentor whose research focuses on CVD; 2) outstanding multidisciplinary faculty who are experienced in training young investigators and can quickly establish this T32 program for fostering successful progress in academic medicine; 3) access to multiple phenotypic and biologic materials from major NIH-funded basic science, prospective cohort, or clinical trials at VCU through the supporting program faculty; 4) courses provided by the existing graduate school and medical faculty that supplement areas of CV research not previously experienced by trainees; and 5) two institutional seminar programs that enhances interaction among individuals from multiple disciplines. The proposed training program includes 15 faculty from 7 departments; these faculty currently mentor 11 individuals who meet the program eligibility criteria. Each has NIH or VA extramural funding; strong institutional support in the form of financial resources, facilities, and equipment; robust integration with the VCU Center of Health Disparities for recruiting and training minority scientists; and support for key professional development activities such as presentations and grant and manuscript writing. The ultimate goal of this T32 training program is to attract and train a cohort of outstanding academic scientists fluent in the latest developments of CV multidisciplinary translational research, who will then apply this knowledge to design and lead future studies regarding important questions in cardiovascular health. The proposed training program, with an emphasis on training both MD and PhD investigators, would augment the supply of physicians and scientists capable of developing new advances in multi- disciplinary translational cardiovascular research directed toward the treatment and prevention of cardiovascular disease, a major public health issue.

该计划旨在培养能够开发新进展的博士后内科医生和科学家 在针对诊断、治疗和治疗的多学科转化性心血管研究中 预防心血管疾病(CVD)。在世界范围内，心血管疾病是发病率和死亡率的主要原因。 对于那些30岁的人；不幸的是，在美国，经过多年的下降，心血管疾病的发病率现在正在上升 流行率。该计划将有助于解决医学博士和博士研究人员数量不足的问题(a NHLBI工作组审查研究、培训和职业发展计划发现的不足) 接受了多学科心血管疾病研究活动的培训，这些活动需要寻求解决方案来减轻 心血管疾病。我们的5年计划包括从预科五年级开始，对4名MD申请者进行为期2年的培训， 和3名博士申请者，从0年级开始，为期3年。该计划建立在以下研究优势的基础上： 弗吉尼亚联邦大学(VCU)涉及基础和临床翻译简历科学使用细胞， 小动物，单中心和多中心人群队列和临床试验。此建议的主要特点 T32培训计划包括：1)将每个受训者与外部资助的研究导师配对，其 专注于心血管疾病的研究；2)优秀的多学科教师，具有培养年轻人才的经验 研究人员并可以快速建立这一T32计划，以促进学术上的成功进步 医学；3)从NIH资助的主要基础科学获得多种表型和生物材料， 未来队列，或VCU通过支持计划教师进行的临床试验；4)由 现有的研究生院和医学院，补充以前没有经历过的简历研究领域 由受训人员提供；以及5)两个机构研讨会计划，加强来自 多学科。拟议的培训计划包括来自7个系的15名教员；这些教员 目前指导了11名符合计划资格标准的个人。每个人都有NIH或VA的壁外 资金；以财政资源、设施和设备的形式提供的强有力的机构支持；强有力的 与VCU健康差距中心整合，以招募和培训少数族裔科学家；并支持 用于关键的专业发展活动，如演讲、赠款和手稿写作。这个 T32培训计划的最终目标是吸引和培养一批优秀的学术科学家 精通简历多学科翻译研究的最新发展，谁将应用这一点 设计和领导关于心血管健康重要问题的未来研究的知识。这个 拟议的培训方案，重点是培训医学博士和博士研究人员，将 增加能够在多学科领域取得新进展的医生和科学家的供应 旨在治疗和预防心血管疾病的学科转化性研究 心血管疾病是一个重大的公共卫生问题。