The Microbiome, Metabolome, and Genome in Multiplex IBD Family Clusters
多重 IBD 家族簇中的微生物组、代谢组和基因组
基本信息
- 批准号:10681314
- 负责人:
- 金额:$ 16.59万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-08-01 至 2027-05-31
- 项目状态:未结题
- 来源:
- 关键词:AffectAgeAreaAwardBirth OrderCharacteristicsChildhoodChronicClinicalClinical ImmunologyCohort StudiesCollaborationsComplexDataDevelopmentDiagnosisDiseaseEnrollmentEnvironmentEventEvolutionFaithFamilyFamily ResearchFamily memberFecesFirst Degree RelativeFundingGastroenterologyGeneticGenetic RiskGenomeGenomicsGoalsHeritabilityImmuneImmune responseInflammatoryInflammatory Bowel DiseasesInstitutionInternationalLeadershipLifeLinkLongitudinal cohortMeasuresMentorsMetagenomicsModelingParentsParticipantPathogenesisPatientsPhasePopulationPreventionPrevention MeasuresRelative RisksResearchResearch PersonnelRiskRisk FactorsRoleRunningShapesSiblingsStatistical MethodsStratificationTraining ActivityTwin StudiesUnited States National Institutes of HealthValidationcareercareer developmentclinical careclinical centercohortdisorder preventiondisorder riskdysbiosisgenome sciencesgenomic datahigh riskimprovedindexinginflammatory markermedical schoolsmembermetabolomemetabolomicsmicrobialmicrobiomemicrobiome researchmid-career facultynovelpatient orientedpersonalized medicinepolygenic risk scorepre-clinicalprofessorprogramsrandom forestrisk prediction modelrisk stratificationrisk variantskillsward
项目摘要
This project will seek to define the relative risk contributions of microbial and genetic factors to the
development of inflammatory bowel disease (IBD) within a cohort of high-risk multiplex (3 first-degree relatives
affected) IBD families. Candidate: The primary objective of this application is to support Dr. Elizabeth
Spencer’s career development into an independent, patient-oriented investigator in the field of prevention and
personalized medicine for IBD patients. Dr. Spencer’s career goal is to become an independent researcher
and leader in the application of risk stratification and prevention for IBD. Dr. Spencer’s proposed training
activities are in five areas: 1) microbiomics, 2) metabolomics, 3) computational genomics and metagenomics,
4) longitudinal cohort building, and 5) leadership. To achieve this, she has assembled a mentoring team led by
Dr. Marla Dubinsky, Co-Director of the IBD Clinical Center at Mount Sinai and Chief of the Division of Pediatric
Gastroenterology, an expert in IBD risk stratification, Dr. Judy Cho, Ward-Coleman Professor, Vice-Chair of
Genetics & Genomics & Gastroenterology, and Director of the Charles Bronfman Institute for Personalized
Medicine (IPM) at the Icahn School of Medicine at Mount Sinai (ISMMS), an expert in the genetics of IBD, and
Dr. Jeremiah Faith, Associate Professor of Genetics and Genomic Sciences and Clinical Immunology and
Director of the Microbiome Translational Center, an expert in microbiomic analysis. Environment: The ISMMS
has a strong tradition of outstanding research and is one of the top 20 medical schools in NIH funding. The
Mount Sinai Division of Pediatric Gastroenterology is an international leader in IBD research and clinical care.
Research: IBD is a heterogenous set of chronic inflammatory disorders that arise from the complex interplay
of genetic, environmental and microbial factors, and immune responses. These complicated interactions arise
before the identification of overt disease, making it difficult to tease out the causative factors behind disease
inception given the need for a pre-clinical, high-risk cohort. The Multiplex Families Research Program at
ISMMS provides a unique cohort of affected and unaffected members of multiplex families with IBD to examine
the relative contribution of these factors. Dr. Spencer’s preliminary observations in this cohort have shown that
siblings with IBD tend to cluster together in birth order, likely due to some environmental sharing, which could
be attributed to microbial changes. We would like to explore this further by characterizing the microbial and
genetic contributions to familial IBD to improve stratification of those at high-risk for developing both pre-clinical
and overt IBD. Therefore, our specific aims are (1) to define the features of microbial and metabolomic profiles
in sibling clusters of IBD and their association with genetic risk and (2) to develop an IBD risk score
incorporating genetic, microbial, and metabolomic factors with validation in a similar, external cohort. The
general approaches and skills developed during this award can be applied to further IBD risk stratification and
continued exploration of possible inciting environmental triggers for those at high-risk for IBD.
该项目将寻求确定微生物和遗传因素对
炎症性肠病(IBD)在高危多发性肠病(3个一级亲属)队列中的发展
受影响的)IBD家庭。候选人:这个应用程序的主要目标是支持伊丽莎白博士
斯宾塞的职业生涯发展成为一名独立的、以患者为导向的预防和治疗领域的调查员
针对IBD患者的个性化用药。斯宾塞博士的职业目标是成为一名独立研究人员
在IBD风险分层和预防方面的应用方面处于领先地位。斯宾塞博士提议的培训
活动涉及五个领域:1)微生物学,2)代谢组学,3)计算基因组学和元基因组学,
4)纵向队列建设,5)领导力。为了实现这一目标,她组建了一个由
Marla Dubinsky博士,西奈山IBD临床中心联席主任兼儿科科长
胃肠病学,IBD风险分层专家,Ward-Coleman教授,副主席
遗传学、基因组学和胃肠病学,查尔斯·布朗夫曼个性化研究所所长
西奈山伊坎医学院(ISMMS)的医学(IPM),IBD遗传学专家,以及
耶利米·费思博士,遗传学和基因组科学与临床免疫学副教授
微生物组翻译中心主任,微生物组分析专家。环境:ISMMS
拥有优秀研究的深厚传统,是NIH资助的前20所医学院之一。这个
西奈山儿科消化内科在IBD研究和临床护理方面处于国际领先地位。
研究:IBD是一组异质性慢性炎症性疾病,由复杂的相互作用引起
遗传、环境和微生物因素,以及免疫反应。这些复杂的相互作用就产生了
在确定显性疾病之前,很难找出疾病背后的致病因素
考虑到临床前、高风险队列的需要。多个家庭研究计划位于
ISMMS提供了患有IBD的多个家庭中受影响和未受影响的成员的独特队列以进行检查
这些因素的相对贡献。斯宾塞博士在这个队列中的初步观察表明
患有IBD的兄弟姐妹在出生顺序上倾向于聚集在一起,可能是因为一些共同的环境,这可能
可归因于微生物的变化。我们想通过对微生物和
对家族性IBD的遗传贡献以改善临床前发展的高危人群的分层
和公开的IBD。因此,我们的具体目标是(1)确定微生物和代谢组学的特征
在IBD的兄弟姐妹群中及其与遗传风险的关联以及(2)开发IBD风险评分
结合遗传、微生物和代谢因素,在类似的外部队列中进行验证。这个
在该奖项期间开发的一般方法和技能可应用于进一步的IBD风险分层和
继续探索对IBD高危人群可能的环境诱因。
项目成果
期刊论文数量(6)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
The Combination of Predictive Factors of Pharmacokinetic Origin Associates with Enhanced Disease Control during Treatment of Pediatric Crohn's Disease with Infliximab.
- DOI:10.3390/pharmaceutics15102408
- 发表时间:2023-09-30
- 期刊:
- 影响因子:5.4
- 作者:Dubinsky MC;Rabizadeh S;Panetta JC;Spencer EA;Everts-van der Wind A;Dervieux T
- 通讯作者:Dervieux T
Barriers to optimizing inflammatory bowel disease care in the United States.
- DOI:10.1177/17562848231169652
- 发表时间:2023
- 期刊:
- 影响因子:4.2
- 作者:Spencer, Elizabeth A.;Abbasi, Sadeea;Kayal, Maia
- 通讯作者:Kayal, Maia
Single-center Experience With Upadacitinib for Adolescents With Refractory Inflammatory Bowel Disease.
Upadacitinib 用于治疗难治性炎症性肠病青少年的单中心经验。
- DOI:10.1093/ibd/izad300
- 发表时间:2023
- 期刊:
- 影响因子:4.9
- 作者:Spencer,ElizabethA;Bergstein,Suzannah;Dolinger,Michael;Pittman,Nanci;Kellar,Amelia;Dunkin,David;Dubinsky,MarlaC
- 通讯作者:Dubinsky,MarlaC
Poor prognostic factors of pharmacokinetic origin predict outcomes in inflammatory bowel disease patients treated with anti-tumor necrosis factor-α.
药代动力学起源的不良预后因素可预测接受抗肿瘤坏死因子-α 治疗的炎症性肠病患者的结果。
- DOI:10.3389/fimmu.2024.1342477
- 发表时间:2024
- 期刊:
- 影响因子:7.3
- 作者:Spencer,ElizabethA;Dubinsky,MarlaC;Kamm,MichaelA;Chaparro,Maria;Gionchetti,Paolo;Rizzello,Fernando;Gisbert,JavierP;Wright,EmilyK;Schulberg,JulienD;Hamilton,AmyL;McGovern,DermotPB;Dervieux,Thierry
- 通讯作者:Dervieux,Thierry
Prognostication in inflammatory bowel disease.
- DOI:10.3389/fmed.2022.1025375
- 发表时间:2022
- 期刊:
- 影响因子:3.9
- 作者:
- 通讯作者:
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Elizabeth Spencer其他文献
Elizabeth Spencer的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Elizabeth Spencer', 18)}}的其他基金
The Microbiome, Metabolome, and Genome in Multiplex IBD Family Clusters
多重 IBD 家族簇中的微生物组、代谢组和基因组
- 批准号:
10525276 - 财政年份:2022
- 资助金额:
$ 16.59万 - 项目类别:
相似国自然基金
靶向递送一氧化碳调控AGE-RAGE级联反应促进糖尿病创面愈合研究
- 批准号:JCZRQN202500010
- 批准年份:2025
- 资助金额:0.0 万元
- 项目类别:省市级项目
对香豆酸抑制AGE-RAGE-Ang-1通路改善海马血管生成障碍发挥抗阿尔兹海默病作用
- 批准号:2025JJ70209
- 批准年份:2025
- 资助金额:0.0 万元
- 项目类别:省市级项目
AGE-RAGE通路调控慢性胰腺炎纤维化进程的作用及分子机制
- 批准号:
- 批准年份:2024
- 资助金额:0 万元
- 项目类别:面上项目
甜茶抑制AGE-RAGE通路增强突触可塑性改善小鼠抑郁样行为
- 批准号:2023JJ50274
- 批准年份:2023
- 资助金额:0.0 万元
- 项目类别:省市级项目
蒙药额尔敦-乌日勒基础方调控AGE-RAGE信号通路改善术后认知功能障碍研究
- 批准号:
- 批准年份:2022
- 资助金额:33 万元
- 项目类别:地区科学基金项目
补肾健脾祛瘀方调控AGE/RAGE信号通路在再生障碍性贫血骨髓间充质干细胞功能受损的作用与机制研究
- 批准号:
- 批准年份:2022
- 资助金额:52 万元
- 项目类别:面上项目
LncRNA GAS5在2型糖尿病动脉粥样硬化中对AGE-RAGE 信号通路上相关基因的调控作用及机制研究
- 批准号:n/a
- 批准年份:2022
- 资助金额:10.0 万元
- 项目类别:省市级项目
围绕GLP1-Arginine-AGE/RAGE轴构建探针组学方法探索大柴胡汤异病同治的效应机制
- 批准号:81973577
- 批准年份:2019
- 资助金额:55.0 万元
- 项目类别:面上项目
AGE/RAGE通路microRNA编码基因多态性与2型糖尿病并发冠心病的关联研究
- 批准号:81602908
- 批准年份:2016
- 资助金额:18.0 万元
- 项目类别:青年科学基金项目
高血糖激活滑膜AGE-RAGE-PKC轴致骨关节炎易感的机制研究
- 批准号:81501928
- 批准年份:2015
- 资助金额:18.0 万元
- 项目类别:青年科学基金项目
相似海外基金
Holocene Landscape History in the forest area „Schweinert“ – a geoarchaeological study in Germany’s largest Bronze Age barrow cemetery
森林地区全新世景观历史“Schweinert”——德国最大的青铜时代手推墓地的地质考古研究
- 批准号:
452251818 - 财政年份:2020
- 资助金额:
$ 16.59万 - 项目类别:
Research Grants
Empirical study on the Iron Production of the Early Iron Age in the Area of Altai Extending over Four Countries
阿尔泰地区四国早期铁器时代铁矿生产实证研究
- 批准号:
17H01646 - 财政年份:2017
- 资助金额:
$ 16.59万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
Religious Paracelsianism: Science and Religion in the German-speaking Area of the Early Modern Age
宗教帕拉塞尔西主义:近代早期德语区的科学与宗教
- 批准号:
16K21332 - 财政年份:2016
- 资助金额:
$ 16.59万 - 项目类别:
Grant-in-Aid for Young Scientists (B)
Age and significance of permafrost landforms in the Fort McMurray area
麦克默里堡地区多年冻土地貌的年龄和意义
- 批准号:
478568-2015 - 财政年份:2015
- 资助金额:
$ 16.59万 - 项目类别:
University Undergraduate Student Research Awards
Late Neolithic/Early Bronze Age developments in the south-west Baltic area (2500-1500 BC): Why did the Bruszczewo-Leki Male type of power structures appear?
波罗的海西南部地区新石器时代晚期/青铜时代早期的发展(公元前2500-1500年):为什么会出现布鲁什切沃-莱基男性类型的权力结构?
- 批准号:
277223019 - 财政年份:2015
- 资助金额:
$ 16.59万 - 项目类别:
Research Grants
'Ritual feasting' in the Late Bronze Age in the northwestern Carpathian area -archaeological and scientific aspects
喀尔巴阡山脉西北部地区青铜时代晚期的“仪式盛宴”——考古和科学方面
- 批准号:
287419687 - 财政年份:2015
- 资助金额:
$ 16.59万 - 项目类别:
Research Grants
Research on the Folk House of Yeosu Area in a Modern Age -Consideration from a Viewpoint of the Influence of the Ocean Culture Area-
近代丽水地区民居研究-从海洋文化区影响的角度思考-
- 批准号:
26420607 - 财政年份:2014
- 资助金额:
$ 16.59万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
A study about the age and the production area of the Yan Guo and Liaoning Area Remains in the Spring and Autumn Warring States Period
春秋战国时期燕国及辽宁地区遗存的年代及产地研究
- 批准号:
25300043 - 财政年份:2013
- 资助金额:
$ 16.59万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
The formation process of Tai Hang mountains area in Final stage of Chinese Neolithic age : Focused on analysing pottery
中国新石器时代末期大坑山区的形成过程——以陶器为重点分析
- 批准号:
23820059 - 财政年份:2011
- 资助金额:
$ 16.59万 - 项目类别:
Grant-in-Aid for Research Activity Start-up
Bronze Age Carian Iasos: Structures, Stratigraphy, and Finds from the area of the Late Roman Agora (ca. 3000-1500 BC)
青铜时代卡里安亚索斯:晚期罗马集市(约公元前 3000-1500 年)地区的结构、地层学和发现物
- 批准号:
AH/I001611/1 - 财政年份:2011
- 资助金额:
$ 16.59万 - 项目类别:
Fellowship














{{item.name}}会员




