KBASE2: Korean Brain Aging Study, Longitudinal Endophenotypes and Systems Biology

KBASE2：韩国大脑衰老研究、纵向内表型和系统生物学

• 批准号: 10680421
• 负责人: Dong Young Lee
• 金额: $ 234.46万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-15 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10680421
• 关键词: Acceleration; Address; Age; Aging; Alzheimer' s Disease; American; Amyloid; Angiography; Asian; Asian population; Automobile Driving; Back; Biological Markers; Blood; Blood Vessels; Brain; California; Clinical; Clinical Data; Clinical assessments; Cognition; Cognitive; Collaborations; Collection; Complement; Data; Data Collection; Data Set; Dementia; Development; Diagnostic; Diffusion Magnetic Resonance Imaging; Disease; Disease Progression; Early Diagnosis; Elements; Enrollment; Ethnic Population; European ancestry; Follow-Up Studies; Functional Magnetic Resonance Imaging; Genes; Genetic; Genetic Risk; Genetic Transcription; Genetic Variation; Genetic study; Genome; Genomics; Goals; Heterogeneity; Image; Indiana; Institution; International; Korea; Koreans; Laboratories; Machine Learning; Magnetic Resonance Imaging; Memory; Methods; Molecular; Multiomic Data; Nerve Degeneration; Network-based; Participant; Pathology; Pathway Analysis; Pathway interactions; Pennsylvania; Phenotype; Population; Positron-Emission Tomography; Prevention; Process; Prospective, cohort study; Public Health; Reporting; Research; Resources; Rest; Risk; Sampling; Science; Systems Biology; Translations; Universities; aging brain; cerebrovascular; cohort; comparative; computerized data processing; data harmonization; data sharing; data storage site; design; drug development; endophenotype; fluorodeoxyglucose positron emission tomography; functional genomics; genetic analysis; genetic variant; genomic data; imaging biomarker; insight; lifestyle data; longitudinal analysis; member; mild cognitive impairment; multi-ethnic; multidisciplinary; multimodal data; multimodal neuroimaging; multimodality; multiple omics; neuroimaging; neuroimaging marker; novel diagnostics; novel strategies; polygenic risk score; precision medicine; prevent; prognostic; programs; progression marker; prospective; protective allele; risk variant; sample collection; specific biomarkers; tau Proteins; therapeutic development; therapeutic target; transcriptome sequencing; transcriptomics; whole genome; working group

Project Summary/Abstract The Korean Brain Aging Study for the Early Diagnosis and Prediction of AD (KBASE) is a comprehensive prospective cohort study launched at Seoul National University (SNU) in 2014 using a similar design and methods as the North American Alzheimer’s Disease Neuroimaging Initiative (ADNI). The KBASE cohort consists of well-characterized participants including cognitively normal (CN) controls with a wide age range (20 to 90 years), mild cognitive impairment (MCI) and AD dementia (AD). A unique aspect of KBASE is the systematic longitudinal collection of comprehensive clinical, cognitive and lifestyle data, multimodal neuroimaging (MRI/MRA, DTI, rsfMRI, amyloid, tau and FDG PET), and bio-specimens in Korea for the first five years (“KBASE1”). Some KBASE data have been analyzed and reported but much of the extensive KBASE data set and samples await comprehensive analysis. The proposed project (“KBASE2”) represents a collaboration between the NIA Alzheimer’s Disease Sequencing Project (ADSP) and partners, Indiana University (ADNI Genetics Core, Indiana NIA-designated ADRC, and IU Network Science Institute), the KBASE team at SNU in Korea, University of Southern California (USC), and the University of Pennsylvania. Over 1000 whole genome sequences (WGS) of Korean participants will be contributed to the ADSP, and the extensive ADSP multi-ethnic data set will be analyzed. WGS data will be harmonized by the NIA Genetics and Genomics Center for AD (GCAD) and shared via the NIA Genetics of AD Data Storage Site (NIAGADS). The Laboratory of Neuroimaging (LONI) at USC will support sharing of MRI and PET and related endophenotypes, as it does for ADNI. KBASE2 will continue longitudinal data and sample collection and provide high throughput WGS and RNA-Seq as well as data harmonization and sharing (Aim 1), perform intensive brain network-based analyses of longitudinal amyloid, tau, neurodegeneration and vascular (A/T/N/V) imaging biomarkers in relation to clinical data (Aim 2), employ integrative systems biology and functional genomics methods to analyze multi-omics data for association with A/T/N/V biomarkers for AD, and provide new insight into AD biomarker-related dysregulated gene modules and pathways (Aim 3). The overarching concepts driving this multidisciplinary international collaborative project are that 1) development of precision medicine for AD and related disorders (ADRD) requires systematic multi-modal biomarker collection in diverse cohorts during early at-risk stages of disease to identify robust diagnostic, prognostic and therapeutic targets and 2) sophisticated analytic strategies that address the complexity of multi- layer multimodal data and heterogeneous and diverse participant cohorts are essential. We hypothesize that integrative longitudinal analysis of genetic and -omics networks with structural and functional brain networks will yield new diagnostic and treatment-relevant insights related to A/T/N/V and other aging related pathways. Results of this collaboration and data sharing will facilitate translation of ADSP findings for therapeutic development in support of the National Alzheimer's Project Act goal of prevention and treatment of AD by 2025.

项目总结/文摘

项目成果

Association of Central Auditory Processing Dysfunction With Preclinical Alzheimer's Disease.

中枢听觉处理功能障碍与临床前阿尔茨海默病的关联。

• DOI: 10.1002/ohn.228
• 发表时间: 2023
• 期刊: Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
• 作者: Byun,MinSoo;Chang,Munyoung;Yi,Dahyun;Ahn,Hyejin;Han,Dongkyun;Jeon,Seulki;Jang,Hyunsook;Lee,DongYoung;Oh,SeungHa;KBASEResearchGroup
• 通讯作者: KBASEResearchGroup

Circadian rest-activity rhythm and longitudinal brain changes underlying late-life cognitive decline.

• DOI: 10.1111/pcn.13521
• 发表时间: 2023-04
• 期刊: PSYCHIATRY AND CLINICAL NEUROSCIENCES
• 影响因子: 11.9
• 作者: Jeon, So Yeon;Byun, Min Soo;Yi, Dahyun;Jung, Gijung;Lee, Jun-Young;Kim, Yu Kyeong;Sohn, Chul-Ho;Kang, Koung Mi;Lee, Yu Jin;Lee, Dong Young;KBASE Research Group
• 通讯作者: KBASE Research Group

Sex differences in the progression of glucose metabolism dysfunction in Alzheimer's disease.

• DOI: 10.1038/s12276-023-00993-3
• 发表时间: 2023-05
• 期刊: EXPERIMENTAL AND MOLECULAR MEDICINE
• 影响因子: 12.8
• 作者: Park, Jong-Chan;Lim, Hanbyeol;Byun, Min Soo;Yi, Dahyun;Byeon, Gihwan;Jung, Gijung;Kim, Yu Kyeong;Lee, Dong Young;Han, Sun-Ho;Mook-Jung, Inhee
• 通讯作者: Mook-Jung, Inhee

Association between brain amyloid deposition and longitudinal changes of white matter hyperintensities.

脑淀粉样蛋白沉积与白质高信号纵向变化之间的关联。

• DOI: 10.1186/s13195-024-01417-8
• 发表时间: 2024
• 期刊: Alzheimer's research & therapy
• 作者: Cha,Woo-Jin;Yi,Dahyun;Ahn,Hyejin;Byun,MinSoo;Chang,YoonYoung;Choi,Jung-Min;Kim,Kyungtae;Choi,Hyeji;Jung,Gijung;Kang,KoungMi;Sohn,Chul-Ho;Lee,Yun-Sang;Kim,YuKyeong;Lee,DongYoung
• 通讯作者: Lee,DongYoung

Body mass index and two-year change of in vivo Alzheimer's disease pathologies in cognitively normal older adults.

• DOI: 10.1186/s13195-023-01259-w
• 发表时间: 2023-06-13
• 期刊: Alzheimer's research & therapy