Clinical Translational Core
临床转化核心
基本信息
- 批准号:10678894
- 负责人:
- 金额:$ 16.48万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-07-15 至 2026-05-31
- 项目状态:未结题
- 来源:
- 关键词:AcuteAddressAdvertisementsAgeAnimalsArchitectureAreaBehaviorBioinformaticsBiological MarkersBiometryBrainClinicClinicalClinical TrialsClinical and Translational Science AwardsClinical assessmentsCodeCohort StudiesCollaborationsCommunitiesComputational LinguisticsComputer Vision SystemsComputer softwareConsultationsContractsCustomDataData AnalysesData AnalyticsData ElementData Science CoreData SetDatabase Management SystemsDatabasesDevelopmental DisabilitiesDiagnosticEducationElectronic Health RecordEligibility DeterminationExclusion CriteriaFacial ExpressionFamilyGaitGenesGeneticGenomicsGoalsHospitalsHouseholdHumanIndividualInstitutional Review BoardsIntellectual and Developmental Disabilities Research CentersIntellectual functioning disabilityLanguageLeadershipLegalLibrariesLightLinkMachine LearningMapsMeasurementMeasuresMediationMissionNational Institute of Mental HealthNeuropsychologyNewsletterOutcome MeasurePatient RecruitmentsPatientsPhasePhenotypePre-Clinical ModelPreparationPrimary CareProcessProtocols documentationProviderQuality ControlQuestionnairesReportingReproducibilityReproducibility of ResultsResearchResearch PersonnelResearch Project GrantsResearch SupportResource AllocationResourcesSamplingSchoolsScienceServicesSiteSpeechStructureTechniquesTechnologyTextTrainingTranslatingTranslational ResearchTreatment outcomeVisualization softwareclinical phenotypeclinical translationcohortcomputable phenotypesdashboarddata archivedata harmonizationdata integrationdata managementdata submissiondata visualizationdesigndigitaldisabilityfallsinnovationmedical specialtiesneuralneural circuitneuroimagingnon-verbalnovelphenotypic dataprogramspsychologicrecruitresearch studyresponsesocial mediatoolweb site
项目摘要
(CORE B- CTC: CLINICAL TRANSLATIONAL CORE)
PROJECT SUMMARY
Description: The Clinical Translational Core (CTC) provides a comprehensive set of services designed to
enhance the impact and rigor of clinical translational research on Intellectual and Developmental Disabilities
(IDD). Select services are novel and unavailable outside of the CTC; other services increase research efficiency
and enhance quality control over study activities common to all CT research. Freeing individual IDDRC users of
the burden of common activities in turn allows users to better deploy resources for innovation and maximizing
the impact of their translational science. CTC services fall into four areas: (1) Assistance with assembling suitably
large study cohorts to support rigorous, well-powered research. Recruitment of large samples is necessary for
studies of developmental disabilities which have diverse clinical manifestations that must be measured and
controlled for in data analyses to garner reproducible results. (2) Creation of study specific interactive databases
and visualization tools which allow labs to track their study progress, efficiently allocate resources and effort, and
prepare study reports and data submissions (e.g., NIMH Data Archive). The CTC, in collaboration with the
Genomics and Data Integration and Neuroimaging and Neurocircuitry cores, support integration of different data
types. (3) Support all phases of IRB and IND protocol preparation, submission and response to stipulations; and
provide concierge services for other freely available research supports already on campus, such as services
offered by CHOP’s Clinical Trials office, and services provided by the Penn/CHOP Clinical and Translational
Science Award (CTSA). (4) Expert clinical assessment support, including support with conventional
psychological measurement; computable phenotypes from bioinformatic analyses of the electronic health
records (EHR); and novel digital phenotyping using computer vision and computational linguistics to achieve
granular measurement of speech, language and observable behaviors (e.g., nonverbal facial expressions and
synchrony between individuals during interactions). These technologies and analytic capabilities are especially
valued as they are not otherwise available on campus or commercially. The CTC will partner with the Preclinical
Models Core on computer vision measurement of animal and human behaviors (e.g., gait), to derive features for
mapping across species in order to more rapidly translate study findings and validate promising treatments.
Relevance to IDDRC Mission: The CTC facilitates interdisciplinary translational research and training in IDDs
(e.g., by working closely with the Leadership Education in Neurodevelopmental and Related Disabilities (LEND)
program). The CTC provides centralized resources as well as novel cutting-edge techniques to support and
advance IDD research linking genes, brain and behavior. The CTC is integral to advancing science that will
impact the lives of those with an intellectual and/or developmental disability.
Eligibility: Services are available to approved users of the CHOP/Penn IDDRC and for cross-site collaborations
with others within the IDDRC network.
(CORE B-CTC:临床翻译核心)
项目总结
描述:临床翻译核心(CTC)提供一整套服务,旨在
提高智力和发育障碍临床转化研究的影响力和严谨性
(IDD)。选定的服务是新颖的,在反恐中心之外是不可用的;其他服务提高了研究效率
并加强对所有CT研究共同的研究活动的质量控制。将IDDRC的个人用户从
共同活动的负担反过来又允许用户更好地配置资源来进行创新和最大化
他们的翻译科学的影响。CTC服务分为四个领域:(1)协助适当组装
支持严谨、有力的研究的大型研究队列。招募大样本是必要的
对具有不同临床表现的发育性残疾的研究必须测量和
受控于数据分析,以获得可重现的结果。(2)建立专门针对研究的互动数据库
和可视化工具,使实验室能够跟踪他们的研究进度,高效地分配资源和工作,以及
准备研究报告和数据提交(例如,NIMH数据档案)。反恐委员会与
基因组学和数据集成以及神经成像和神经电路核心,支持不同数据的集成
类型。(3)支持IRB和IND协议的编制、提交和响应规定的所有阶段;以及
为校园内已有的其他免费研究支持提供礼宾服务,如服务
由CHOP的临床试验办公室提供,由宾夕法尼亚大学/CHOP临床和翻译中心提供服务
科学奖(CTSA)。(4)专家临床评估支持,包括常规支持
心理测量.电子健康的生物信息学分析的可计算表型
记录(EHR);以及使用计算机视觉和计算语言学实现的新的数字表型
语音、语言和可观察行为的细粒度测量(例如,非语言面部表情和
在交互过程中个体之间的同步)。这些技术和分析能力尤其
因为它们在校园或商业上是不可用的。CTC将与临床前
以计算机视觉测量动物和人类行为(例如步态)为核心的模型,以推导出
绘制不同物种的地图,以便更快地转化研究结果并验证有前景的治疗方法。
与IDDRC任务的相关性:反恐委员会促进IDDS方面的跨学科翻译研究和培训
(例如,通过与神经发育和相关残疾领导教育(LAND)密切合作)
计划)。反恐委员会提供集中的资源以及新颖的尖端技术,以支持和
推进IDD研究,将基因、大脑和行为联系起来。反恐委员会对于推动科学进步是不可或缺的,它将
影响智力和/或发育障碍者的生活。
资格:CHOP/Penn IDDRC的批准用户和跨站点协作均可获得服务
与IDDRC网络内的其他人进行合作。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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ROBERT Thomas SCHULTZ其他文献
ROBERT Thomas SCHULTZ的其他文献
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{{ truncateString('ROBERT Thomas SCHULTZ', 18)}}的其他基金
Predicting Autism and Social Functioning from Computer Vision Analyses of Motor Synchrony During Dyadic Interactions
通过计算机视觉对二元交互过程中运动同步的分析来预测自闭症和社交功能
- 批准号:
10057391 - 财政年份:2019
- 资助金额:
$ 16.48万 - 项目类别:
Predicting Autism and Social Functioning from Computer Vision Analyses of Motor Synchrony During Dyadic Interactions
通过计算机视觉对二元交互过程中运动同步的分析来预测自闭症和社交功能
- 批准号:
10540333 - 财政年份:2019
- 资助金额:
$ 16.48万 - 项目类别:
Novel computer vision-based assessment of infant-caregiver synchrony as an early level II screening tool for autism
基于计算机视觉的婴儿-看护者同步性评估作为自闭症早期 II 级筛查工具
- 批准号:
10023938 - 财政年份:2019
- 资助金额:
$ 16.48万 - 项目类别:
Predicting Autism and Social Functioning from Computer Vision Analyses of Motor Synchrony During Dyadic Interactions
通过计算机视觉对二元交互过程中运动同步的分析来预测自闭症和社交功能
- 批准号:
10308068 - 财政年份:2019
- 资助金额:
$ 16.48万 - 项目类别:
Testing the hyperspecificity hypothesis: a neural theory of autism
检验超特异性假说:自闭症的神经理论
- 批准号:
8514729 - 财政年份:2012
- 资助金额:
$ 16.48万 - 项目类别:
Testing the hyperspecificity hypothesis: a neural theory of autism
检验超特异性假说:自闭症的神经理论
- 批准号:
8359473 - 财政年份:2012
- 资助金额:
$ 16.48万 - 项目类别:
Developing a Community-Based ASD Research Registry
开发基于社区的 ASD 研究登记处
- 批准号:
7830900 - 财政年份:2009
- 资助金额:
$ 16.48万 - 项目类别:
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