Clinical Translational Core

临床转化核心

• 批准号: 10678894
• 负责人: ROBERT Thomas SCHULTZ
• 金额: $ 16.48万
• 依托单位: CHILDREN'S HOSP OF PHILADELPHIA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-15 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10678894
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(CORE B- CTC: CLINICAL TRANSLATIONAL CORE) PROJECT SUMMARY Description: The Clinical Translational Core (CTC) provides a comprehensive set of services designed to enhance the impact and rigor of clinical translational research on Intellectual and Developmental Disabilities (IDD). Select services are novel and unavailable outside of the CTC; other services increase research efficiency and enhance quality control over study activities common to all CT research. Freeing individual IDDRC users of the burden of common activities in turn allows users to better deploy resources for innovation and maximizing the impact of their translational science. CTC services fall into four areas: (1) Assistance with assembling suitably large study cohorts to support rigorous, well-powered research. Recruitment of large samples is necessary for studies of developmental disabilities which have diverse clinical manifestations that must be measured and controlled for in data analyses to garner reproducible results. (2) Creation of study specific interactive databases and visualization tools which allow labs to track their study progress, efficiently allocate resources and effort, and prepare study reports and data submissions (e.g., NIMH Data Archive). The CTC, in collaboration with the Genomics and Data Integration and Neuroimaging and Neurocircuitry cores, support integration of different data types. (3) Support all phases of IRB and IND protocol preparation, submission and response to stipulations; and provide concierge services for other freely available research supports already on campus, such as services offered by CHOP’s Clinical Trials office, and services provided by the Penn/CHOP Clinical and Translational Science Award (CTSA). (4) Expert clinical assessment support, including support with conventional psychological measurement; computable phenotypes from bioinformatic analyses of the electronic health records (EHR); and novel digital phenotyping using computer vision and computational linguistics to achieve granular measurement of speech, language and observable behaviors (e.g., nonverbal facial expressions and synchrony between individuals during interactions). These technologies and analytic capabilities are especially valued as they are not otherwise available on campus or commercially. The CTC will partner with the Preclinical Models Core on computer vision measurement of animal and human behaviors (e.g., gait), to derive features for mapping across species in order to more rapidly translate study findings and validate promising treatments. Relevance to IDDRC Mission: The CTC facilitates interdisciplinary translational research and training in IDDs (e.g., by working closely with the Leadership Education in Neurodevelopmental and Related Disabilities (LEND) program). The CTC provides centralized resources as well as novel cutting-edge techniques to support and advance IDD research linking genes, brain and behavior. The CTC is integral to advancing science that will impact the lives of those with an intellectual and/or developmental disability. Eligibility: Services are available to approved users of the CHOP/Penn IDDRC and for cross-site collaborations with others within the IDDRC network.

（核心B- CTC：临床翻译核心） 项目摘要 描述：临床翻译核心（CTC）提供了一套旨在的全面服务 增强智力和发育障碍临床翻译研究的影响和严格 （IDD）。精选服务是新颖的，在CTC之外无法使用；其他服务提高了研究效率 并增强对所有CT研究共同研究活动的质量控制。释放个人IDDRC用户 共同活动的燃烧反过来允许用户更好地部署资源来创新和最大化 他们的翻译科学的影响。 CTC服务属于四个领域：（1）合适组装的协助 大型研究队列，以支持严格的，有力的研究。招募大型样品是必要的 具有潜水临床表现的发育障碍的研究，必须衡量和 在数据分析中受控以获得可重复的结果。 （2）创建研究特定交互式数据库 和可视化工具，使实验室能够跟踪其学习进度，有效地分配资源和精力，以及 准备研究报告和数据提交（例如NIMH数据存档）。 CTC与 基因组学和数据整合以及神经成像和神经记录核，支持不同数据的整合 类型。 （3）支持IRB和IND协议准备，提交和对规定的响应的所有阶段；和 为校园中的其他免费研究支持提供礼宾服务，例如服务 由CHOP的临床试验办公室提供，以及Penn/Chop临床和翻译提供的服务 科学奖（CTSA）。 （4）专家临床评估支持，包括传统的支持 心理测量；来自电子健康的生物信息学分析的可计算表型 记录（EHR）;以及使用计算机视觉和计算语言学实现的新型数字表型 语音，语言和可观察行为的颗粒状测量（例如，非语言面部表情和 互动过程中个体之间的同步）。这些技术和分析能力尤其是 值得在校园或商业上不可用。 CTC将与临床前合作 模型核心在计算机视觉测量动物和人类行为（例如步态）的核心，以得出特征 跨物种的映射以更快地翻译研究结果并验证承诺治疗。 与IDDRC任务相关：CTC促进IDDS跨学科翻译研究和培训 （例如，通过与神经发育和相关残疾的领导力教育紧密合作（LEND） 程序）。 CTC提供集中资源以及新颖的尖端技术来支持和 提前IDD研究将基因，大脑和行为联系起来。 CTC是前进科学不可或缺的一部分 影响智力和/或发育障碍的人的生活。 资格：可用于批准的CHOP/PENN IDDRC的用户和跨站点协作 在IDDRC网络中与其他人在一起。