Training in Signal Transduction and Cellular Endocrinology

描述(由申请人提供)： 这次竞争性更新是针对伊利诺伊大学芝加哥分校的信号转导培训计划(STTP)，该计划现已有10年历史。STTP提供信号转导、基因转录和翻译以及细胞内分泌学方面的跨学科博士前培训，重点是细胞和分子机制，这些机制传递信号并调节细胞、组织和有机体的发育，以及环境和免疫反应。目标是在信号转导和细胞内分泌学的广泛方面培训博士前候选人，以培养独立的基础科学家和临床研究人员。过去十年的STTP主题是促进教师、研究人员和项目之间的培训环境互动，这些项目正在使用不同的实验系统和方法来了解生物组织的不同水平上的信号转导机制，包括分子、细胞和整体生物生物学。STTP跨越学科、系和学院的界限，利用来自六个基础科学系(解剖学和细胞生物学、生物化学和分子遗传学、微生物学和免疫学、药理学、生理学和生物物理学以及生物工程)和四个临床科(血液肿瘤学、内分泌和代谢、肺和重症护理、泌尿科)的35名教员的专业知识，利用广泛的分子、生化、生理学、遗传学、结构和动物模型综合生物学方法，在信号转导和相关领域的广泛问题上提供培训机会。信号转导、膜受体、第二信使、细胞周期调控、基因转录、癌症生物学、哺乳动物发育、内分泌和神经体液信号是STTP的主要优势。博士前培训包括理论、技术和研究视角，通过授课课程、研究报告、研讨会、研究轮换和非正式互动。在UIC的跨学科医学研究生教育(GEMS)计划中，信号转导、内分泌学的专业课程和核心课程包括分子和细胞生物学、生物化学、遗传学、结构生物学、生理学、药理学、科学交流和负责任的研究行为，为密集的研究培训环境奠定了基础。教师培训师的研究兴趣包括神经体液信号、膜受体和第二信使、细胞周期控制、转录、翻译和表观遗传基因调控、发育和结构生物学。STTP强调当代信号转导和细胞内分泌学研究在培养独立和创造性思维的环境中的跨学科性质，并正在为产生独立研究人员做出贡献，他们现在正在这一广泛领域做出重大贡献，并开始丰富科学进步和科学研究界。

DESCRIPTION (provided by applicant): This competitive renewal is for the now 10-year old Signal Transduction Training Program (STTP) at the University of Illinois at Chicago. The STTP provides interdisciplinary predoctoral training in signal transduction, gene transcription and translation, and cellular endocrinology, with strong emphasis on cellular and molecular mechanisms that transduce signals and regulate cell, tissue and organismal development, and environmental and immunologic responses. The goal is the training of predoctoral candidates in broad aspects of signal transduction and cellular endocrinology to develop independent basic scientists and clinical investigators. An STTP theme for the past ten years is the promotion of training environment interactions between faculty researchers and programs that are using different experimental systems and approaches to understand signal transduction mechanisms at various levels of biological organization including molecular, cellular and integrative whole organism biology. The STTP crosses disciplinary, departmental and college lines, drawing upon the expertise of 35 faculty from six basic science departments (anatomy & cell biology, biochemistry & molecular genetics, microbiology & immunology, pharmacology, physiology & biophysics and bioengineering), and four clinical sections (hematology-oncology, endocrinology and metabolism, pulmonary and critical care, urology), offering training opportunities in wide ranging problems in signal transduction and allied areas using a broad spectrum of molecular, biochemical, physiologic, genetic, structural and animal model integrative biology approaches. Signal transduction, membrane receptors, second messengers, cell cycle regulation, gene transcription, cancer biology, mammalian development, endocrine and neurohumoral signaling are major strengths of the STTP faculty. Predoctoral training includes theory, techniques and research perspectives through didactic courses, research presentations, seminars, research rotations and informal interactions. Specialized courses in signal transduction, endocrinology, and a core curriculum in the interdisciplinary Graduate Education in Medical Sciences (GEMS) program at UIC in molecular and cellular biology, biochemistry, genetics, structural biology, physiology, pharmacology, scientific communication and responsible conduct of research provide the foundation for an intensive research training environment. Faculty trainer research interests range from neurohumoral signaling, membrane receptors and second messengers, cell cycle control, transcriptional, translational and epigenetic gene regulation, developmental and structural biology. The STTP emphasizes the interdisciplinary nature of contemporary research in signal transduction and cellular endocrinology in an environment fostering independent and creative thinking, and is contributing to the generation of independent investigators who are now making significant contributions in this broad area, and who beginning to enrich scientific progress and the scientific research community.