Animal and Human Imaging Shared Resource

动物和人类成像共享资源

• 批准号: 10682585
• 负责人: Todd E Peterson
• 金额: $ 25.17万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10682585
• 关键词: Address; Animal Cancer Model; Animal Experimentation; Animal Model; Animals; Breast; Cancer Center Support Grant; Clinical; Clinical Trials; Collaborations; Data; Data Analyses; Dedications; Development; Effectiveness; Ensure; Environment; Equipment; Event; Experimental Designs; Faculty; Funding; Goals; Good Manufacturing Process; Healthcare; Histology; Human; Image; Image Analysis; Imaging Techniques; Individual; Institution; Investigational Drugs; Investigational New Drug Application; Isotopes; Magnetic Resonance; Magnetic Resonance Imaging; Malignant Neoplasms; Mentorship; Methods; Mission; Modality; Molecular; Monitor; Non-Invasive Detection; Nuclear; Optics; PET/CT scan; Patients; Phase; Physicians; Positron-Emission Tomography; Preparation; Production; Proteomics; Protocols documentation; Radiochemistry; Radiopharmaceuticals; Reproducibility; Research; Research Personnel; Resource Sharing; Resources; Scientist; Services; Specialized Program of Research Excellence; Students; System; Talents; The Vanderbilt-Ingram Cancer Center at the Vanderbilt University; Time; Tracer; Training; Ultrasonography; Universities; animal imaging; biomedical imaging; cancer clinical trial; cancer imaging; clinical imaging; clinically relevant; design; experimental study; gastrointestinal; human imaging; human model; imager; imaging facilities; imaging modality; imaging probe; imaging science; imaging scientist; imaging study; imaging system; improved; in vivo; innovation; instrument; method development; multimodality; non-invasive imaging; novel; pre-clinical; precision oncology; programs; quantitative imaging; response; responsible research conduct; single photon emission computed tomography; tumor; tumor metabolism; ultrasound

CORE 002 – ANIMAL AND HUMAN IMAGING SHARED RESOURCE PROJECT SUMMARY/ABSTRACT The Animal and Human Imaging Shared Resource (AHISR) has been continuously supported by the Cancer Center Support Grant (CCSG) since 2004. The AHISR provides scientific and technical assistance for experiments employing biomedical imaging for the study of cancer in both the pre-clinical and clinical settings and continues to undertake developments to meet ongoing needs. As in previous cycles, the AHISR remains a critical component of VICC’s Specialized Programs of Research Excellence (SPORE) programs, with both recently renewed Breast and Gastrointestinal (GI) SPOREs having featured imaging components. In 2018, the AHISR was integral to landing a new NCI-funded co-clinical imaging trial resource (U24) focused on quantitative PET imaging of cancer metabolism with investigational radiopharmaceuticals. Furthermore, the AHISR expertise and capabilities have enabled a new partnership between VICC and GE Health Care (GEHC), where quantitative cancer imaging and radiopharmaceutical discovery are central pillar programs of a major precision oncology initiative. The faculty and staff within the AHISR provide access to state-of-the-art imaging facilities including advanced human MRI systems operating at 3T and 7T, a research-dedicated PET/CT, ultrasound scanner, and a comprehensive facility for multimodal animal imaging and research radiopharmaceuticals for animal and human use. Furthermore, the AHISR leverages the institutional resources within the Vanderbilt University Institute of Imaging Science (VUIIS) to develop new and improved methods for obtaining information that addresses research questions of direct cancer relevance. More specifically, the AHISR will provide: 1. Collaborations with expert imaging science faculty (in nuclear, optical, magnetic resonance and ultrasound imaging) for the development and application of cutting-edge imaging protocols 2. Innovative and novel radiopharmaceuticals for animal and human imaging research 3. Support for imaging system operators and technical staff who will handle patient and animal preparation and monitoring as well as operate the instruments 4. Support for data analysis and for quantitative image analysis customized to specific applications including the co-registration and integration of multiple modalities, histology and proteomics. The AHISR brings together advanced equipment and diverse expertise into a comprehensive integrated resource that ensures the quality of the imaging data, and consequently, the overall quality, rigor, and reproducibility of the studies is the highest possible.

核心002 - 动物和人类成像共享资源 项目摘要/摘要 动物和人类成像共享资源（AHISR）一直受到癌症的不断支持 自2004年以来 在临床前和临床环境中，采用生物医学成像研究癌症的实验 并继续进行发展以满足持续的需求。与以前的周期一样，AHISR仍然是 VICC专业的研究卓越计划（Spore）计划的关键组成部分，两者都 最近，具有成像成分的乳房和胃肠道（GI）孢子。在2018年 AHISR是降落新的NCI资助的共同成像试验资源（U24）不可或缺的一部分 使用研究放射性药物的癌症代谢的宠物成像。此外，AHISR专业知识 能力和能力已经在VICC和GE Health Care（GEHC）之间建立了新的合作伙伴关系， 癌症成像和放射药物发现是主要精确肿瘤学的中心支柱程序 倡议。 AHISR中的教职员工提供了对最新成像设施的访问 高级人类MRI系统在3T和7T上运行，一项研究的PET/CT，超声扫描仪和 用于动物和动物的多模式动物成像和研究放射性药物的全面设施 人使用。此外，AHISR利用范德比尔特大学内的机构资源 成像科学研究所（VUIIS）开发新的和改进的方法，以获取信息 解决了直接癌症相关性的研究问题。更具体地说，AHISR将提供： 1。与专家成像科学教师合作（核，光学，磁共振和 超声成像）用于开发和应用尖端成像协议 2。动物和人类成像研究的创新和新颖的放射性药物 3.支持成像系统操作员和技术人员，他们将处理患者和动物准备 和监视以及操作仪器 4。支持数据分析和定量图像分析，定制为特定应用程序，包括 多种方式，组织学和蛋白质组学的共同注册和整合。 AHISR将高级设备和潜水专业知识融合在一起，成为全面的综合综合 确保成像数据质量的资源，从而确保整体质量，严谨和 研究的可重复性最高。