Automated Cassette-Based Radiosynthesis Equipment

基于盒的自动化放射合成设备

• 批准号: 10177621
• 负责人: Todd E Peterson
• 金额: $ 20.14万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-06-01 至 2022-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10177621
• 关键词: Cardiovascular Diseases; Core Facility; Equipment; Funding; Future; Generations; Health; High Pressure Liquid Chromatography; Human; Image; Institutes; Malignant Neoplasms; Modernization; Molecular; PET/CT scan; Performance; Positron-Emission Tomography; Production; Radiochemistry; Request for Applications; Research; Research Personnel; Science; Services; System; United States National Institutes of Health; Universities; base; imaging system; nervous system disorder; novel; novel therapeutic intervention; pre-clinical; radiotracer

Project Summary This application requests funding to support the purchase of a modernized automated PET radiochemistry cassette synthesis platform for PET radiotracer production. The system will be installed at the Vanderbilt University Institute of Imaging Science’s Radiochemistry Core (RCC) facility; a core that allows access to research radiotracers for use on three human PET/CT imaging systems, two pre-clinical PET imaging systems and a variety of other end uses. The core also offers expertise in allowing investigators to develop novel radiotracers for routine production. The RCC currently operates a GE TRACERLab MX module as the main GMP production module for a number of heavily utilized radiotracers. However, the TRACERLab MX, a 30-year-old, early-generation automated cassette radiosynthesis module with dated performance and declining health, has outlasted its projected use and both parts and service are no longer available. Thus, the proposed GE Fastlab 2 with HPLC+ was chosen to replace the existing and obsolete TRACERLab MX. Breakage of the TRACERLab MX would cause major disruptions to the core’s ability to support all ongoing NIH-funded studies that use radiotracers produced on this module. The Fastlab 2 with HPLC+ will substantially advance our radiotracer production capabilities, especially with the addition of the HPLC purification system married to a cassette-based radiosynthesis module. This upgraded capability would allow for more reliable production of some of the most requested radiotracers and allow for smooth integration of newly developed radiotracers to support ongoing future NIH-funded research. The proposed system will be placed in the radiochemistry core and used to support current and future NIH-funded research ranging from studying the molecular basis of cancer, cardiovascular, and neurological diseases to developing novel therapeutic approaches.

项目摘要 该申请要求资金支持购买现代化的自动化宠物放射化学 PET放射性示踪剂生产的盒式合成平台。该系统将安装在范德比尔特 大学成像科学研究所的放射化学核心（RCC）设施；允许访问的核心 用于在三个人类PET/CT成像系统的研究放射性示例，这是两个临床前PET成像系统 以及各种其他最终用途。核心还提供了专业知识，可以使研究人员开发新颖 用于常规生产的放射性示例。 RCC当前运行GE TracerLab MX模块作为主要GMP 用于多种大量使用的放射性示例的生产模块。但是，30岁的Tracerlab MX MX 早期生成自动盒放射合成模块具有过时的表现和健康状况下降，具有 超过预计的使用，零件和服务不再可用。那就是拟议的GE FastLab 2 选择HPLC+以替换现有和过时的Tracerlab MX。破坏曲目 MX会导致核心支持所有正在进行的NIH资金研究的能力的重大破坏 在该模块上产生的放射性示例。带有HPLC+的FastLab 2将大大提高我们的radiotracer 生产能力，尤其是加入HPLC纯化系统与基于盒的HPLC纯化系统 放射合成模块。这种升级的功能将使最可靠的生产最可靠 请求的是放射性示例，并允许新开发的放射性示例平稳整合 未来NIH资助的研究。提出的系统将放置在放射化学核心中，并用于支持 当前和未来的NIH资助的研究范围从研究癌症的分子基础，心血管， 和神经系统疾病开发新的治疗方法。