Pilot Projects

设计了生物分子结构与动力学中心（CBSD）COBRE的试点项目计划 为初级研究人员的研究计划提供种子，并为已建立的研究人员提供资金， 将他们的研究项目推向新的方向。这个项目建立在一个类似项目的成功基础上 在CBSD COBRE的第一和第二阶段实施。前几个阶段资助的28个试点项目 COBRE的支持导致了32项赠款，为CBSD带来了总计1550万美元的资金 investigators.试点项目计划还导致了对COBRE-supported四个项目的大量使用。 研究核心和充值收入的相关增加。我们将继续刺激增长， CBSD研究资金和我们的研究核心的使用，通过分配COBRE和机构资金， 坚持这个有价值的计划。在COBRE支持的第一和第二阶段，我们将利用试点项目计划， 为初级调查员的职业生涯奠定基础（具体目标1），并协助资深调查员寻求新的 研究方向（具体目标2）。扩大该计划对我们研究增长的影响 在第三阶段，为了增强我们研究核心的能力，我们还将优先考虑试点项目 涉及多PI合作（具体目标3）或推动新核心开发的项目 技术（具体目标4）。前者将允许开发赠款提交， 后者将有助于保持我们的研究核心处于技术前沿。的关键 我们的试点项目计划的成功将是有效的指导计划（具体目标5），如热 水奖写作研讨会。我们将继续通过评估其 通过外部咨询委员会的年度投入，我们可以最大限度地发挥其影响力， 我们的研究努力。增加研究经费的试验计划的良好记录 CBSD研究人员的生产力和推动我们研究核心的技术发展是一个关键 我们的战略计划的一部分，以维持CBSD后，第三阶段COBRE资金。

The Pilot Project program of the Center for Biomolecular Structure and Dynamics (CBSD) COBRE is designed to seed the research programs of junior investigators and to provide established investigators with funding to move their research programs in new directions. This program builds on the success of a similar program implemented during phases I and II of the CBSD COBRE. The 28 Pilot Projects funded during previous phases of COBRE support led to 32 grant awards that brought in a total of $15.5 million of funding to CBSD investigators. The Pilot Project program also led to a large increase in the use of the four COBRE-supported research cores and an associated increase in recharge income. We will continue to stimulate the growth of CBSD research funding and the use of our research cores by allocating COBRE and institutional funds to sustain this valuable program. As in phases I and II of COBRE support, we will use the Pilot Project program to seed the careers of junior investigators (specific aim 1) and to assist established investigators in pursuing new research directions (specific aim 2). To expand the impact of this program on the growth of our research enterprise and to enhance the capabilities of our research cores during phase III, we also will prioritize Pilot Projects that involve multi-PI collaborations (specific aim 3) or drive the development of new core technologies (specific aim 4). The former will allow for the development of grant submissions with a strong competitive edge and the latter will help to keep our research cores at the technological forefront. Critical to the success of our Pilot Project program will be effective mentoring programs (specific aim 5), such as the Hot Water grant writing workshop. We will continue to improve the Pilot Project program by evaluating its effectiveness with annual input from our External Advisory Committee so that we can maximize its impact on our research endeavors. The proven track-record of the Pilot Project program to increase the research funding and productivity of CBSD investigators and to drive technological development in our research cores is a key element of our strategic plan to sustain the CBSD after phase III COBRE funding.