Biomolecular Structure and Dynamics

生物分子结构与动力学

• 批准号: 10004060
• 负责人: BRUCE E BOWLER
• 金额: $ 211.91万
• 依托单位: UNIVERSITY OF MONTANA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10004060
• 关键词: Adopted; Area; Biochemistry; Biological Process; Biology; Biophysics; Cellular biology; Centers of Research Excellence; Chemistry; Chronic; Collaborations; Communities; Core Facility; Development; Discipline; Disease; Docking; Ensure; Enzymes; Evolution; Faculty; Faculty Recruitment; Fluorescence Spectroscopy; Fostering; Foundations; Funding; Genetic Transcription; Goals; Growth; Health; Health Occupations; Humanities; K-Series Research Career Programs; Laboratory Research; Leadership; Mentors; Mentorship; Methods; Modeling; Molecular; Molecular Computations; Molecular Structure; Montana; Neurobiology; Neurodegenerative Disorders; Occupational activity of managing finances; Pathologic; Pharmacologic Substance; Pharmacology; Phase; Physiological Processes; Pilot Projects; Proteins; RNA purification; Research; Research Personnel; Research Project Grants; Research Support; Science; Stream; Structural Chemistry; Structure; Synthesis Chemistry; Time; Training; United States National Institutes of Health; Universities; Work; X ray diffraction analysis; X-Ray Crystallography; biophysical techniques; cohesion; cohort; college; diabetes mellitus therapy; inflammatory lung disease; innovation; macromolecular assembly; member; mid-career faculty; molecular dynamics; molecular mechanics; novel therapeutics; programs; protein expression; protein purification; receptor; recruit; research facility; single molecule; small molecule; structural biology; success; training project

The Center of Biomedical Research Excellence in Biomolecular Structure and Dynamics at the University of Montana (CBSD COBRE) supports research that applies the methods and concepts of biophysics, structural biology and chemistry to understand the mechanistic basis of biological processes in health and disease. CBSD faculty members are drawn from the basic and biomedical sciences in the Colleges of Humanities and Sciences and the College of Health Professions and Biomedical Sciences. Disciplines represented by Center faculty include cellular biology, pharmacology, neurobiology, biochemistry, synthetic chemistry and computational research in chemistry and biology. The first aim of the Phase II CBSD COBRE program is to support and mentor CBSD Investigators by: a) supporting four Junior Project Investigators who will conduct research in the general theme of small molecules that regulate or mimic protein receptors and enzymes; b) conducting an effective and robust mentoring program to guide Junior Investigators along the path towards academic success and independent funding; c) identifying and supporting strong replacement projects within the CBSD research theme, inviting both established investigators and collaborative projects to strengthen the research cohesion of the Center; and d) maintaining a Pilot Project and Bridge-funding Program to encourage innovative explorative research and sustain productive Investigators while they pursue independent funding. Aim 2 of the proposal is to carry on the work of Phase I to build a strong cohort of CBSD investigators though strategic faculty recruitment, supported by Career Development Awards, emphasizing the structure and dynamics of macromolecular assemblies in biological processes. Aim 3 advances the Core Facility structure of the CBSD by: a) maintaining a strong Administrative Core that provides effective leadership, oversight and financial management of the Center; b) developing additional capability in the Macromolecular X-ray Diffraction Core Facility to conduct protein expression and purification, as well as small molecule X-ray crystallography; c) developing advanced capabilities in the BioSpectroscopy Core Research Laboratory in time-resolved fluorescence spectroscopy, including single molecule analysis, and d) consolidating an integrated collaborative facility for protein modeling and molecular and dynamics in the Molecular Computation Core Facility. Aim 4 of the application is to conduct an array of programmatic activities to promote program cohesion and scientific excellence. An important overall goal of this proposal is to foster a self-sustainable Center by mentoring and supporting a community of outstanding junior and established investigators, and by adopting multiple funding streams to ensure sustainable Core Research Facilities.

生物分子结构和动力学卓越生物医学研究中心 蒙大拿州（CBSD COBRE）支持应用生物物理学、结构和生物学的方法和概念的研究。 生物学和化学，以了解健康和疾病的生物过程的机械基础。 CBSD教师来自人文学院的基础科学和生物医学科学， 科学和卫生保健和生物医学科学学院。中心代表的学科 教师包括细胞生物学，药理学，神经生物学，生物化学，合成化学和 化学和生物学的计算研究。第二阶段CBSD COBRE计划的首要目标是 通过以下方式支持和指导CBSD研究者：a）支持四名初级项目研究者，他们将进行 研究调节或模拟蛋白质受体和酶的小分子的一般主题; B） 开展有效和强有力的指导计划，引导初级调查员沿着通往 学术上的成功和独立的资金; c）确定和支持强有力的替代项目， CBSD的研究主题，邀请既建立调查和合作项目，以加强 中心的研究凝聚力;以及d）保持试点项目和桥梁资助计划，以鼓励 创新的探索性研究和维持生产调查，而他们追求独立的资金。 该提案的目标2是继续第一阶段的工作，建立一支强大的CBSD研究人员队伍， 战略性的教师招聘，由职业发展奖支持，强调结构和 生物过程中大分子组装的动力学。目标3推进核心融资结构， CBSD通过：a）保持一个强大的行政核心，提供有效的领导，监督和 中心的财务管理; B）发展高分子X射线衍射的额外能力 核心设施进行蛋白质表达和纯化，以及小分子X射线晶体学; c） 在生物光谱核心研究实验室开发先进的能力， 荧光光谱，包括单分子分析，和d）巩固一个综合的合作 分子计算核心设施中的蛋白质建模和分子动力学设施。目标4 应用程序是进行一系列的方案活动，以促进方案的凝聚力和科学性 卓越本提案的一个重要总体目标是通过指导和培训， 支持优秀的初级调查员和资深调查员社区，并采用多种资金 以确保可持续的核心研究设施。