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Biomolecular Structure and Dynamics: Equipment Supplement for Zeiss 880 Airyscan Upgrade

生物分子结构和动力学：Zeiss 880 Airyscan 升级的设备补充

基本信息

批准号：
10580417
负责人：
BRUCE E BOWLER
金额：
$ 20.58万
依托单位：
UNIVERSITY OF MONTANA
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-08-10 至 2026-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10580417
关键词：
Applications Grants Area Award Basic Science Biological Process Biomimetics Biophysics Budgets Centers of Research Excellence Communities Computational Biology Core Facility Counseling Cryoelectron Microscopy Development Diabetes Mellitus Disease Docking Educational workshop Ensure Equipment Evolution Extramural Activities Faculty Fees Financial Support Fluorescence Fostering Foundations Funding Future Genes Genetic Transcription Goals Grant Grant Review Growth Health Human Humanities Imaging Techniques Incentives Infrastructure Institutes Investments Laboratory Research Lead Ligands Malignant Neoplasms Mass Spectrum Analysis Mathematical Biology Mentors Methods Mission Modernization Molecular Molecular Computations Monitor Montana Neurodegenerative Disorders Pathologic Peer Review Phase Physiological Processes Pilot Projects Positioning Attribute Proteomics Publications Research Research Personnel Research Support Resolution Resources Role Sampling Science Seeds Services Structural Chemistry Structure Translational Research United States National Institutes of Health Universities Water Work Writing base career cellular imaging cohort college design drug development drug discovery fluorescence lifetime imaging human pathogen imaging capabilities in vivo instrumentation macromolecule member metabolomics molecular dynamics novel therapeutics programs protein expression receptor research facility single molecule small molecule structural biology success two-dimensional

项目摘要

The Center of Biomedical Research Excellence in Biomolecular Structure and Dynamics (CBSD COBRE) at the University of Montana (UM) supports research that applies the methods and concepts of biophysics, structural biology and chemistry to understand the mechanistic basis of biological processes in health and disease. The CBSD COBRE draws from a pool of about 60 faculty members from the basic and biomedical sciences in the College of Humanities and Sciences and the College of Health. This phase III proposal builds on the successes of phases I and II of COBRE support for the CBSD that have led to the hiring of seven new faculty and early career support for an additional nine UM faculty. The direct COBRE support for their research efforts, the COBRE-supported research cores that underpin their research programs and the vibrant seminar and mentoring programs sponsored by the CBSD COBRE have propelled these early career investigators to success. As a cohort, they have been awarded 39 grants that brought in $16.8 million to support their research and have generated 83 well-cited peer-reviewed publications. During phases I and II, the CBSD COBRE has supported four research cores, the Integrated Structural Biology Core (ISBC), which provides gene to structure services, the BioSpectroscopy Core Research Laboratory (BCRL), which gives CBSD researchers access to state-of-the-art fluorescence lifetime and imaging instrumentation, the Molecular Computation Core Facility (MCCF), which provides molecular docking, drug discovery and molecular dynamics (MD) platforms, and the Mass Spectrometry Core Facility (MSCF), which applies proteomic and metabolomic approaches to CBSD research problems. The growth in the number of CBSD researchers afforded by investment in early career investigators and strong investment in research core infrastructure during phases I and II of COBRE support, which has included more than $2 million in new equipment resulting from extramural equipment grants, has positioned the CBSD well to attain long-term sustainability with phase III COBRE support. The CBSD COBRE will use the phase III COBRE to pursue three specific aims designed to sustain the CBSD beyond phase III. With specific aim 1, we will continue to expand the cutting-edge capabilities of our research cores by carefully prioritizing COBRE and institutional resources so that the cores respond to the needs of their users and by continuing to vigorously pursue extramural funding for equipment that enhances core infrastructure. Specific aim 2 will evolve the role of the Administrative Core to lead the CSBD to sustainability through strategic financial planning and ongoing mentoring programs that keep CBSD researchers across career stages at the leading edge of their research areas. Finally, specific aim 3 will develop a Pilot Project program designed to incentivize new scientific directions that not only use, but also expand the technical capabilities of our research cores. This carefully-designed framework will ensure the long-term sustainability of the CBSD and the vital research community that it supports.

生物分子结构和动力学生物医学研究卓越中心（CBSD COBRE）