Biomolecular Structure and Dynamics: Equipment Supplement for Zeiss 880 Airyscan Upgrade

生物分子结构和动力学：Zeiss 880 Airyscan 升级的设备补充

• 批准号: 10580417
• 负责人: BRUCE E BOWLER
• 金额: $ 20.58万
• 依托单位: UNIVERSITY OF MONTANA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-10 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10580417
• 关键词: Applications Grants; Area; Award; Basic Science; Biological Process; Biomimetics; Biophysics; Budgets; Centers of Research Excellence; Communities; Computational Biology; Core Facility; Counseling; Cryoelectron Microscopy; Development; Diabetes Mellitus; Disease; Docking; Educational workshop; Ensure; Equipment; Evolution; Extramural Activities; Faculty; Fees; Financial Support; Fluorescence; Fostering; Foundations; Funding; Future; Genes; Genetic Transcription; Goals; Grant; Grant Review; Growth; Health; Human; Humanities; Imaging Techniques; Incentives; Infrastructure; Institutes; Investments; Laboratory Research; Lead; Ligands; Malignant Neoplasms; Mass Spectrum Analysis; Mathematical Biology; Mentors; Methods; Mission; Modernization; Molecular; Molecular Computations; Monitor; Montana; Neurodegenerative Disorders; Pathologic; Peer Review; Phase; Physiological Processes; Pilot Projects; Positioning Attribute; Proteomics; Publications; Research; Research Personnel; Research Support; Resolution; Resources; Role; Sampling; Science; Seeds; Services; Structural Chemistry; Structure; Translational Research; United States National Institutes of Health; Universities; Water; Work; Writing; base; career; cellular imaging; cohort; college; design; drug development; drug discovery; fluorescence lifetime imaging; human pathogen; imaging capabilities; in vivo; instrumentation; macromolecule; member; metabolomics; molecular dynamics; novel therapeutics; programs; protein expression; receptor; research facility; single molecule; small molecule; structural biology; success; two-dimensional

The Center of Biomedical Research Excellence in Biomolecular Structure and Dynamics (CBSD COBRE) at the University of Montana (UM) supports research that applies the methods and concepts of biophysics, structural biology and chemistry to understand the mechanistic basis of biological processes in health and disease. The CBSD COBRE draws from a pool of about 60 faculty members from the basic and biomedical sciences in the College of Humanities and Sciences and the College of Health. This phase III proposal builds on the successes of phases I and II of COBRE support for the CBSD that have led to the hiring of seven new faculty and early career support for an additional nine UM faculty. The direct COBRE support for their research efforts, the COBRE-supported research cores that underpin their research programs and the vibrant seminar and mentoring programs sponsored by the CBSD COBRE have propelled these early career investigators to success. As a cohort, they have been awarded 39 grants that brought in $16.8 million to support their research and have generated 83 well-cited peer-reviewed publications. During phases I and II, the CBSD COBRE has supported four research cores, the Integrated Structural Biology Core (ISBC), which provides gene to structure services, the BioSpectroscopy Core Research Laboratory (BCRL), which gives CBSD researchers access to state-of-the-art fluorescence lifetime and imaging instrumentation, the Molecular Computation Core Facility (MCCF), which provides molecular docking, drug discovery and molecular dynamics (MD) platforms, and the Mass Spectrometry Core Facility (MSCF), which applies proteomic and metabolomic approaches to CBSD research problems. The growth in the number of CBSD researchers afforded by investment in early career investigators and strong investment in research core infrastructure during phases I and II of COBRE support, which has included more than $2 million in new equipment resulting from extramural equipment grants, has positioned the CBSD well to attain long-term sustainability with phase III COBRE support. The CBSD COBRE will use the phase III COBRE to pursue three specific aims designed to sustain the CBSD beyond phase III. With specific aim 1, we will continue to expand the cutting-edge capabilities of our research cores by carefully prioritizing COBRE and institutional resources so that the cores respond to the needs of their users and by continuing to vigorously pursue extramural funding for equipment that enhances core infrastructure. Specific aim 2 will evolve the role of the Administrative Core to lead the CSBD to sustainability through strategic financial planning and ongoing mentoring programs that keep CBSD researchers across career stages at the leading edge of their research areas. Finally, specific aim 3 will develop a Pilot Project program designed to incentivize new scientific directions that not only use, but also expand the technical capabilities of our research cores. This carefully-designed framework will ensure the long-term sustainability of the CBSD and the vital research community that it supports.

生物分子结构和动力学生物医学研究卓越中心(CBSD Cobre) 蒙大拿大学(UM)支持应用生物物理学的方法和概念的研究， 结构生物学和化学，以了解健康和健康中生物过程的机制基础 疾病。CBSD Cobre从大约60名来自基础和生物医学的教职员工中挑选 人文与科学学院和卫生学院的理科专业。此阶段III建议书构建 关于Cobre对CBSD的支持第一阶段和第二阶段的成功，导致雇用了七名新的 为另外九名密歇根大学教职员工提供教师和早期职业支持。科布雷对他们研究的直接支持 努力，科布雷支持的研究核心支持他们的研究计划和充满活力的研讨会 由CBSD Cobre赞助的指导计划推动了这些早期职业调查人员 成功。作为一个队列，他们已经获得了39项拨款，带来了1680万美元的资金来支持他们的研究 并产生了83本被广泛引用的同行评议出版物。在第一和第二阶段，CBSD Cobre已经 支持四个研究核心，集成结构生物学核心(ISBC)，它提供基因与结构 服务，生物光谱核心研究实验室(BCRL)，使CBSD研究人员能够访问 最先进的荧光寿命和成像仪器，分子计算核心设备 (MCCF)，提供分子对接、药物发现和分子动力学(MD)平台，以及 将蛋白质组和代谢组学方法应用于CBSD的质谱学核心设备(MSCF) 研究问题。CBSD研究人员数量的增长是由职业早期投资提供的 在科布雷支持的第一和第二阶段期间，研究人员和对研究核心基础设施的大力投资， 其中包括200多万美元的新设备，这些设备是由外部设备赠款产生的 在Cobre第三阶段的支持下，将CBSD定位得很好，以实现长期可持续性。CBSD眼镜蛇 将利用第三阶段Cobre来实现三个具体目标，旨在维持第三阶段之后的可持续发展。 具体目标1，我们将继续谨慎地扩展我们研究核心的尖端能力 确定Cobre和机构资源的优先顺序，以使核心响应其用户的需求，并通过 继续积极争取为加强核心基础设施的设备提供外部资金。特定的 目标2将发展行政核心的作用，通过战略手段领导可持续发展委员会 财务规划和持续的指导计划，使CBSD研究人员在整个职业生涯阶段 他们研究领域的前沿。最后，具体目标3将制定一项试点项目计划，旨在 激励新的科学方向，不仅使用并扩展我们研究的技术能力 核心。这一精心设计的框架将确保可持续发展战略的长期可持续性和重要的 它所支持的研究社区。