Administrative Core

行政核心

• 批准号: 10686894
• 负责人: DENNIS WILLIAM DICKSON
• 金额: $ 7.62万
• 依托单位: MAYO CLINIC JACKSONVILLE
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-20 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10686894
• 关键词: Accountability; Achievement; Address; Administrator; Advisory Committees; Amyloid beta-Protein; Arizona; Autopsy; Biochemistry; Bioinformatics; Biological; Brain; Caregiver support; Cellular biology; Clinic; Collaborations; Communities; Dedications; Disease; Education; Educational Materials; Ensure; Fostering; Funding Opportunities; Future; Genes; Genetic; Goals; Grant; Health; Health Sciences; Human; Human Subject Research; Institution; Interdisciplinary Study; Letters; Lewy Body Dementia; Libraries; Logistics; London; Maintenance; Molecular Biology; National Institute of Neurological Disorders and Stroke; New York City; Office of Administrative Management; Pathogenesis; Patients; Positioning Attribute; Progress Reports; Proteins; Proteomics; Publications; Quality Control; Records; Reporting; Reproducibility; Research; Research Personnel; Research Proposals; Resource Sharing; Resources; Saint Jude Children' s Research Hospital; Structure; Support Groups; Texas; Therapeutic Intervention; Toxic effect; United Kingdom; United States National Institutes of Health; Universities; Writing; alpha synuclein; brain tissue; college; data resource; data sharing; experience; innovation; insight; lipidomics; meetings; multidisciplinary; nervous system disorder; neuropathology; neurotoxicity; novel; operation; phosphoneuroprotein 14; programs; research in practice; response; responsible research conduct; structural biology; success; synergism; web page; web site

PROJECT SUMMARY – CORE A The Administrative Core is crucial to the operation of the Lewy body dementia Center without Walls (LBD CWOW). It provides administrative, fiscal, and scientific oversight of all cores and projects. It is responsible for maintaining a webpage for reporting on scientific achievements of the Center and establishing a publicly- available library of all subspecies of alpha-synuclein and amyloid-beta characterized by the Center. In conjunction with the other components of the LBD CWOW, Core A assures that educational materials, data, and research resources are available for sharing with other CWOWs and with non-CWOW LBD investigators. Core A assures that the LBD CWOW will cooperate fully with NINDS initiatives and has a dedicated Center Administrator who has experience with fiscal and administrative management of large multi-institutional grants as well as expertise in navigating the Mayo Clinic Brain Bank. To accomplish these goals, Core A has the following specific aims: Specific Aim 1: Provide administrative structure and fiscal oversight for the CWOW. Specific Aim 2: Assume responsibility for the quality control of the Center’s activities by ensuring responsible conduct of research and rigor and reproducibility of research practices. Specific Aim 3: Promote the scientific direction and integration of the Center components by organizing regular Executive Steering Committee meetings and overseeing external collaborations that support the Center cores and projects. Specific Aim 4: Establish an External Advisory Committee and report progress to the NIH. Specific Aim 5: Establish and maintain a publicly-available library of all α-syn and Aβ subspecies characterized by the center in the form of a LBD CWOW website. Specific Aim 6: Promote education on LBD and encourage CWOW investigators to participate in patient and caregiver support groups.

项目概要-核心A 行政核心是路易体痴呆症无墙中心（LBD）运作的关键 CWOW）。它对所有核心和项目提供行政、财政和科学监督。它负责 维护一个网页，报告中心的科学成就，并建立一个公开的- 该中心提供的α-突触核蛋白和淀粉样蛋白-β的所有亚种的可用文库。在 核心A与LBD CWOW的其他组成部分相结合，确保教育材料，数据， 研究资源可与其他CWOW和非CWOW LBD研究者共享。 核心A保证LBD CWOW将与NINDS倡议充分合作，并有一个专门的中心 具有大型多机构财务和行政管理经验的行政人员 赠款以及在马约诊所脑库导航的专业知识。为了实现这些目标，核心A 以下具体目标：具体目标1：提供行政结构和财政监督 哇。具体目标2：负责中心活动的质量控制，确保 负责任的研究行为以及研究实践的严谨性和可重复性。具体目标3：促进 通过组织定期的执行指导，对中心各组成部分进行科学指导和整合 委员会会议和监督支持中心核心和项目的外部合作。 具体目标4：建立外部咨询委员会，并向NIH报告进展情况。具体目标五： 建立并维护一个由该中心表征的所有α-syn和Aβ亚种的公开文库， LBD CWOW网站的形式。具体目标6：促进关于LBD的教育，鼓励CWOW 研究者参加患者和护理人员支持小组。