Administrative Core

行政核心

• 批准号: 10022180
• 负责人: DENNIS WILLIAM DICKSON
• 金额: $ 7.62万
• 依托单位: MAYO CLINIC JACKSONVILLE
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-20 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10022180
• 关键词: Accountability; Achievement; Address; Administrator; Advisory Committees; Amyloid beta-Protein; Arizona; Autopsy; Biochemistry; Bioinformatics; Biological; Brain; Caregiver support; Cellular biology; Clinic; Collaborations; Communities; Disease; Education; Educational Materials; Ensure; Fostering; Funding Opportunities; Future; Genes; Genetic; Goals; Grant; Health; Health Sciences; Human; Human Subject Research; Interdisciplinary Study; Letters; Lewy Body Dementia; Libraries; Logistics; London; Maintenance; Molecular Biology; National Institute of Neurological Disorders and Stroke; New York City; Office of Administrative Management; Pathogenesis; Patients; Positioning Attribute; Progress Reports; Proteins; Proteomics; Publications; Quality Control; Records; Reporting; Reproducibility; Research; Research Personnel; Research Proposals; Resource Sharing; Resources; Saint Jude Children' s Research Hospital; Structure; Support Groups; Texas; Therapeutic Intervention; Toxic effect; United Kingdom; United States National Institutes of Health; Universities; alpha synuclein; brain tissue; college; data resource; data sharing; education resources; experience; innovation; insight; meetings; multidisciplinary; nervous system disorder; neuropathology; neurotoxicity; novel; operation; programs; research in practice; response; responsible research conduct; structural biology; success; synergism; web page; web site

PROJECT SUMMARY – CORE A The Administrative Core is crucial to the operation of the Lewy body dementia Center without Walls (LBD CWOW). It provides administrative, fiscal, and scientific oversight of all cores and projects. It is responsible for maintaining a webpage for reporting on scientific achievements of the Center and establishing a publicly- available library of all subspecies of alpha-synuclein and amyloid-beta characterized by the Center. In conjunction with the other components of the LBD CWOW, Core A assures that educational materials, data, and research resources are available for sharing with other CWOWs and with non-CWOW LBD investigators. Core A assures that the LBD CWOW will cooperate fully with NINDS initiatives and has a dedicated Center Administrator who has experience with fiscal and administrative management of large multi-institutional grants as well as expertise in navigating the Mayo Clinic Brain Bank. To accomplish these goals, Core A has the following specific aims: Specific Aim 1: Provide administrative structure and fiscal oversight for the CWOW. Specific Aim 2: Assume responsibility for the quality control of the Center’s activities by ensuring responsible conduct of research and rigor and reproducibility of research practices. Specific Aim 3: Promote the scientific direction and integration of the Center components by organizing regular Executive Steering Committee meetings and overseeing external collaborations that support the Center cores and projects. Specific Aim 4: Establish an External Advisory Committee and report progress to the NIH. Specific Aim 5: Establish and maintain a publicly-available library of all α-syn and Aβ subspecies characterized by the center in the form of a LBD CWOW website. Specific Aim 6: Promote education on LBD and encourage CWOW investigators to participate in patient and caregiver support groups.

项目摘要 – 核心 A 行政核心对于路易体痴呆无墙中心 (LBD) 的运营至关重要 CWOW）。它为所有核心和项目提供行政、财政和科学监督。它负责 维护一个用于报告中心科学成就的网页，并建立一个公开的 该中心鉴定了α-突触核蛋白和β-淀粉样蛋白所有亚种的可用文库。在 与 LBD CWOW 的其他组成部分相结合，核心 A 确保教育材料、数据、 研究资源可与其他 CWOW 和非 CWOW LBD 研究人员共享。 核心 A 确保 LBD CWOW 将与 NINDS 倡议充分合作，并设有专门的中心 具有大型多机构财务和行政管理经验的管理员 拨款以及探索梅奥诊所脑库的专业知识。为了实现这些目标，Core A 已 具体目标如下： 具体目标 1：为政府提供行政结构和财政监督 哇。具体目标 2：承担中心活动质量控制的责任，确保 负责任的研究行为以及研究实践的严谨性和可重复性。具体目标 3：促进 通过定期组织行政指导，科学指导和整合中心各组成部分 委员会会议并监督支持中心核心和项目的外部合作。 具体目标 4：建立外部咨询委员会并向 NIH 报告进展情况。具体目标 5： 建立并维护以中心为特征的所有 α-syn 和 Aβ 亚种的公开库 LBD CWOW 网站的形式。具体目标 6：促进 LBD 教育并鼓励 CWOW 研究人员参加患者和护理人员支持小组。