1/2- Feasibility study to build a collaboration in genetics and genomic cancer research

1/2- 建立遗传学和基因组癌症研究合作的可行性研究

• 批准号: 10686191
• 负责人: EMANUELA TAIOLI
• 金额: $ 32.45万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-21 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10686191
• 关键词: Address; African American population; Area; Behavioral; Biological; Biometry; Clinical Investigator; Collaborations; Complement; Consultations; Coupled; Data; Data Collection; Detection; Disparity; Educational Activities; Educational Materials; Educational process of instructing; Ensure; Environment; Environmental Risk Factor; Epidemiology; Etiology; Exposure to; Extramural Activities; Faculty; Feasibility Studies; Funding; Genetic; Genetic Variation; Genomics; Goals; Health; Health Disparities Research; Institution; Interdisciplinary Study; Joints; Lead; Learning; Malignant Neoplasms; Malignant neoplasm of prostate; Mentors; Methodology; Methods; Minority; Outcome; Pilot Projects; Population; Productivity; Records; Registries; Research; Research Institute; Research Personnel; Research Project Grants; Resources; Scientist; Series; Site; Students; Time; Training; Training Activity; Training and Education; Translational Research; Travel; Universities; Vulnerable Populations; anticancer research; cancer epidemiology; cancer genetics; cancer genomics; cancer health disparity; cancer type; didactic education; education research; epidemiology study; experience; faculty research; genetic epidemiology; genomic epidemiology; hands on research; health disparity; improved; innovation; malignant breast neoplasm; medical schools; model building; novel; programs; proton therapy; social factors; statistics; success; survivorship; treatment and outcome; treatment response; undergraduate education

Project Summary This is a partnership between Hampton University (HU) and the Tisch Cancer Institute (TCI) at the Icahn School of Medicine at Mount Sinai that seeks to establish robust collaborations on-site and online training and education to increase HU faculty's research capacity in the area of genetics and genomics and health disparities, while increasing TCI research in health disparities, using the examples of prostate and breast cancer. The final goal is to create a competitive and sustainable joint Center for Genetics and Genomics Cancer Research, encompassing the genetics and genomics aspects of health disparities to explain population differences in breast and prostate cancer occurrence and outcome. The proposal is grounded in a longstanding and productive undergraduate educational collaboration between faculty at these two institutions, but is distinct in its focus, methods, and goals. Hence, the proposed program will utilize the best practices learned from previous collaborative endeavors to inform and create an innovative platform which will enhance research capacity at both institutions while addressing key institutional challenges. Our goals will be accomplished through a series of well-coordinated training/educational activities and two pilot research projects that were strategically chosen to meet our overarching goals of 1) improving health outcomes in vulnerable populations, 2) addressing gaps in cancer disparities research, 3) augmenting genomic, statistics, epidemiology expertise and 4) enhancing investigator productivity and extramural funding competitiveness. Training and education will aim to increase HU faculty's research capacity in the area of genetics and genomics and health disparities, using the examples of prostate and breast cancer. It will provide TCI ISMMS with access and collaboration to scientific projects in breast and prostate cancer disparity etiology, treatment and outcome, as well as to a mechanism to increase the diversity of the genetics and genomics faculty, which has traditionally lacked diversity To ensure the success of the training and education program, we have assembled an excellent team of faculty with outstanding mentoring and teaching track records, along with extensive expertise in developing and implementing new initiatives aimed at diversifying the clinical investigator workforce and eliminating health disparities. HU faculty will also be exposed to the most novel and cutting edge methods in cancer genomics through the completion of the pilot research project.

项目摘要 这是汉普顿大学(HU)和Tisch癌症研究所(TCI)的合作伙伴关系，网址为 位于西奈山的伊坎医学院寻求在现场建立强有力的合作 以及在线培训和教育，以提高HU教师在以下领域的研究能力 遗传学、基因组学和健康差距，同时增加对健康差距的TCI研究， 以前列腺癌和乳腺癌为例。最终目标是创造一个具有竞争力和 可持续的遗传学和基因组学癌症研究联合中心，包括 从遗传学和基因组学角度解释乳房人群差异的健康差异 前列腺癌的发生和转归。 这项提议是基于长期而富有成效的本科教育。 这两个机构的教职员工之间的合作，但其重点、方法和 目标。因此，拟议的方案将利用从以前的 合作努力，提供信息并创建一个创新平台，以加强研究 提高这两个机构的能力，同时应对关键的体制挑战。我们的目标将是 通过一系列协调良好的培训/教育活动和两个试点完成 战略选择的研究项目，以满足我们的总体目标：1)改进 脆弱人群的健康结果，2)解决癌症差异研究中的差距，3) 增强基因组、统计学、流行病学专业知识和4)加强调查人员 生产率和外部资金竞争力。 培训和教育将旨在提高HU教员在遗传学领域的研究能力 以及基因组学和健康差异，以前列腺癌和乳腺癌为例。会的 为TCI ISMMS提供对乳腺和前列腺科学项目的访问和协作 癌症的病因、治疗和结果的差异，以及增加 遗传学和基因组学教师的多样性，传统上缺乏多样性 为了确保培训和教育计划的成功，我们召集了一支优秀的 拥有出色的指导和教学记录的教员团队，以及广泛的 在开发和实施旨在使临床多样化的新计划方面的专业知识 调查人员队伍和消除健康差距。胡教职员工也将接触到 通过试点完成癌症基因组学中最新和最前沿的方法 研究项目。