World Trade Center Tissue Biobank

世界贸易中心组织生物库

• 批准号: 9607412
• 负责人: EMANUELA TAIOLI
• 金额: $ 49.4万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-01 至 2021-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9607412
• 关键词: World; Trade; Center; Tissue; Biobank

Immediately after the 9/11 terrorist attack, concerns were raised about the short and long term effects of exposure to the World Trade Center (WTC) dust cloud. Responders and residents were exposed to a complex mixture of toxic chemicals that included multiple known and suspected human carcinogens which could increase cancer risk. For most solid cancers, the relevant time window between exposure and cancer occurrence is approaching right now, 16 years after the event. The WTCHP has completed the follow-up of all the respondents up to 2014, and has confirmed a possible increase in thyroid and prostate cancers, where the possibility of a biologically more aggressive cancer type due to the nature of the environmental exposure in this population has not been discounted. In parallel with the biomarkers human studies, experimental animal studies of the systemic and local effects of controlled exposure to WTC dust have been conducted, to complement and help interpreting the epidemiological and biomarkers observations reported in the WTC responders cohort. We propose to update the existing biobank of human solid organ tissues from each cancer diagnosed among the WTC rescue and recovery workers, and to include a central repository of tissue samples from various relevant organs from all the animal experiments involving exposure to WTC dust, in order to facilitate and promote future clinical research and translational studies on cancer etiology, cancer biology and cancer outcome. This project proposes to update the central repository of cancer tissue samples and adjacent normal tissue from each solid cancer diagnosed among the WTC Health Program (WTCHP) participants. Relevant information from pathology and cytology reports from each cancer is also centrally stored. This repository has the capability to be linked with the main WTCHP data set containing clinical, epidemiological and exposure information, as well as with the peripheral blood sample collected from the participants at the time of inclusion in the WTCHP. We also propose to initiate and manage a central repository of tissue samples from various organs from rodents exposed to WTC dust at Mount Sinai and NYU. Relevant information from pathology reports will also be centrally stored, along with details of the exposure amount and duration, and of the experimental design. We establish the tissue bank as a resource for the science community, by defining a process for qualified applicants to request available samples for research use, and for linking with the epidemiologic and clinical information in the database. A plan for the evaluation of the tissue bank usage and success, as measured by publications and funding obtained by investigators using the samples, is also included.

9/11恐怖袭击发生后，人们立即对短期和长期 暴露在世界贸易中心(WTC)尘埃云中的影响。响应人员和居民 暴露在一种复杂的有毒化学品混合物中，其中包括多个已知和可疑的 可能会增加癌症风险的人类致癌物质。对于大多数实体癌，相关时间 暴露和癌症发生之间的窗口现在正在逼近，16年后的今天 事件。WTCHP已完成对所有受访者的跟踪，直至2014年，并已 证实了甲状腺和前列腺癌的可能增加，在这些癌症中， 由于环境暴露的性质，在生物学上更具侵袭性的癌症类型 人口并没有被打折扣。与生物标志物同时进行的人体研究，实验性的 对受控暴露于WTC粉尘的全身和局部影响的动物研究已经被 进行，以补充和帮助解释流行病学和生物标志物的观察结果 在世贸中心响应者队列中报告。我们建议更新现有的人类生物库 WTC抢救和康复中诊断出的每一种癌症的实体器官组织 工作人员，并包括来自各种相关组织样本的中央存储库 所有涉及WTC粉尘暴露的动物实验的器官，以便 促进和促进未来癌症病因学的临床研究和翻译研究， 癌症生物学和癌症转归。该项目建议更新中央存储库 癌症组织样本和邻近正常组织来自每一个诊断为 WTC健康计划(WTCHP)参与者。来自病理学和细胞学的相关信息 每种癌症的报告也都集中存储。此存储库具有链接的功能 由于WTCHP的主要数据集包含临床、流行病学和暴露信息，如 以及在纳入时从参与者身上采集的外周血液样本 WTCHP。我们还建议启动和管理一个中央组织样本储存库， 暴露在西奈山和纽约大学WTC粉尘中的啮齿动物的各种器官。相关信息 病理报告也将与暴露剂量的详细信息一起集中存储 持续时间和实验设计。我们建立了组织库，作为 科学界，通过为符合条件的申请者定义一个流程来请求可用的样本 用于研究用途，并与数据库中的流行病学和临床信息相联系。一个 评估组织库使用和成功的计划，由出版物和 调查人员使用样本获得的资金也包括在内。