World Trade Center Tissue Biobank

世界贸易中心组织生物库

• 批准号: 9607412
• 负责人: EMANUELA TAIOLI
• 金额: $ 49.4万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-01 至 2021-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9607412
• 关键词: World; Trade; Center; Tissue; Biobank

Immediately after the 9/11 terrorist attack, concerns were raised about the short and long term effects of exposure to the World Trade Center (WTC) dust cloud. Responders and residents were exposed to a complex mixture of toxic chemicals that included multiple known and suspected human carcinogens which could increase cancer risk. For most solid cancers, the relevant time window between exposure and cancer occurrence is approaching right now, 16 years after the event. The WTCHP has completed the follow-up of all the respondents up to 2014, and has confirmed a possible increase in thyroid and prostate cancers, where the possibility of a biologically more aggressive cancer type due to the nature of the environmental exposure in this population has not been discounted. In parallel with the biomarkers human studies, experimental animal studies of the systemic and local effects of controlled exposure to WTC dust have been conducted, to complement and help interpreting the epidemiological and biomarkers observations reported in the WTC responders cohort. We propose to update the existing biobank of human solid organ tissues from each cancer diagnosed among the WTC rescue and recovery workers, and to include a central repository of tissue samples from various relevant organs from all the animal experiments involving exposure to WTC dust, in order to facilitate and promote future clinical research and translational studies on cancer etiology, cancer biology and cancer outcome. This project proposes to update the central repository of cancer tissue samples and adjacent normal tissue from each solid cancer diagnosed among the WTC Health Program (WTCHP) participants. Relevant information from pathology and cytology reports from each cancer is also centrally stored. This repository has the capability to be linked with the main WTCHP data set containing clinical, epidemiological and exposure information, as well as with the peripheral blood sample collected from the participants at the time of inclusion in the WTCHP. We also propose to initiate and manage a central repository of tissue samples from various organs from rodents exposed to WTC dust at Mount Sinai and NYU. Relevant information from pathology reports will also be centrally stored, along with details of the exposure amount and duration, and of the experimental design. We establish the tissue bank as a resource for the science community, by defining a process for qualified applicants to request available samples for research use, and for linking with the epidemiologic and clinical information in the database. A plan for the evaluation of the tissue bank usage and success, as measured by publications and funding obtained by investigators using the samples, is also included.

9/11恐怖袭击发生后，人们立即提出了对短期和长期的担忧。 暴露在世界贸易中心（WTC）尘埃云中的影响。响应者和居民 暴露于有毒化学物质的复杂混合物，其中包括多种已知和疑似 人类致癌物质，可能会增加癌症风险。对于大多数实体癌， 暴露和癌症发生之间的窗口正在接近，16年后， 活动WTCHP已经完成了截至2014年对所有答复者的跟踪，并 证实了甲状腺癌和前列腺癌的可能增加， 生物学上更具侵略性的癌症类型，由于这种环境暴露的性质， 人口并没有减少。与生物标志物人类研究平行， 对控制暴露于世贸中心粉尘的全身和局部影响的动物研究已经 进行，以补充和帮助解释流行病学和生物标志物观察结果 在WTC应答者队列中报告。我们建议更新现有的人类生物库， WTC救援和恢复期间诊断的每种癌症的实体器官组织 工人，并包括一个中央储存库的组织样本，从各种相关的 器官从所有动物实验涉及暴露于世贸中心灰尘，以 促进和促进未来的癌症病因学临床研究和转化研究， 癌症生物学和癌症结果。本项目建议更新 癌症组织样品和来自在所述患者中诊断的每种实体癌的相邻正常组织。 WTC健康计划（WTCHP）参与者。病理学和细胞学相关信息 每种癌症的报告也集中存储。此存储库具有链接功能 WTCHP的主要数据集包含临床、流行病学和接触信息， 以及在纳入研究时从参与者收集的外周血样品。 WTCHP。我们还建议启动和管理一个中央组织样本库， 西奈山和纽约大学暴露于世贸中心灰尘的啮齿动物的各种器官。相关信息 病理学报告中的数据也将集中存储，沿着暴露量的详细信息， 持续时间和实验设计。我们建立了组织库， 科学界，为合格的申请人确定一个程序，要求提供样品， 研究用途，并与数据库中的流行病学和临床信息相关联。一 组织库使用和成功评估计划，通过出版物和 研究人员使用样本获得的资金也包括在内。