Project 1: Childhood Maltreatment, Repetitive Negative Thinking, and Mental Health in Adolescence: A 12-Year Longitudinal Study

项目 1：童年期虐待、重复性消极思维和青春期心理健康：一项为期 12 年的纵向研究

• 批准号: 10686044
• 负责人: Chrystal Vergara-Lopez
• 金额: $ 19.27万
• 依托单位: MIRIAM HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-15 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10686044
• 关键词: Adaptive Behaviors; Adult; Affective; Age; Attention; Case Study; Categories; Centers of Research Excellence; Child; Child Abuse and Neglect; Childhood; Chronic; Cognition; Cognitive; Data; Development; Dimensions; Ecological momentary assessment; Emotional; Emotions; Environment; Etiology; Executive Dysfunction; Exposure to; Female; Funding; Health; Implicit Association Test; Individual Differences; Intervention; Laboratories; Learning; Life; Link; Mediating; Memory; Mental Health; Mental disorders; Modeling; Neurosciences; Outcome; Participant; Pathway interactions; Pattern; Persons; Phase; Process; Protocols documentation; Psychological reinforcement; Punishment; Reaction Time; Regulation; Research; Research Project Grants; Rewards; Risk; Risk Factors; Sampling; Severities; Sexual abuse; Shapes; Stress; Symptoms; System; Technology; Testing; Thinking; Time; Trauma; attentional bias; career; childhood adversity; clinically relevant; cognitive ability; cognitive control; deprivation; emerging adult; emerging adulthood; emotion regulation; emotional abuse; emotional neglect; emotional stimulus; executive function; experience; falls; flexibility; follow-up; forging; health assessment; indexing; maltreatment; novel; personalized medicine; physical abuse; physical neglect; psychologic; recruit; resilience; resilience factor; social; synergism; theories; visual tracking; young adult

PROJECT SUMMARY / ABSTRACT COBRE Research Project 1 will enable Project Lead Vergara-Lopez to collect pilot data in support of a competitive R01 application investigating the influence of childhood maltreatment on repetitive negative thinking (RNT), and risk for mental health problems. Early life adversity alters cognitive processes; these effects become more evident as children transition to adolescence. However, the cognitive mechanisms by which childhood adversity confers risk for adolescent psychopathology are not well understood. We propose that cognitive control deficits, specifically poor set-shifting when processing emotional stimuli, leads to difficulty disengaging from negative content and experiences of repetitive negative thinking (RNT). RNT - a recurrent and difficult to control process focused on negative content has been proposed as a transdiagnostic cognitive risk factor across internalizing (e.g., depression, anxiety) and externalizing (e.g., substance use, aggression) problems. Yet, there are no studies that examine the role of RNT as it unfolds in vivo among adolescents with exposure to childhood adversity. This is a critical missed clinical opportunity because RNT may serve as a proximal malleable antecedent to a broad range of mental health problems, and thus, a potential transdiagnostic treatment target. Adolescents with comprehensive child protective services verified histories of maltreatment and other adversities (determined by contextual stress interviews, and self/parental report), will be recruited from a 12-year longitudinal study. We will capitalize on the infrastructure of this longitudinal study that has richly characterized maltreatment and other adverse exposures utilizing multi-method, multi-informant assessment of maltreatment in early childhood (ages 3-5) and middle childhood (ages 9-11) across exposure type, chronicity, and severity. We will recruit adolescents between 15-17 years old and a caregiver. Adolescents (N=75), and their caregivers will attend a laboratory visit to assess mental health via diagnostic clinical interviews and self-report measures. The adolescents will complete a cognitive control battery, a RNT induction paired with a free-view eye-tracking paradigm to assesses difficulty disengaging from negative content (i.e., how much participants visually dwell or perseverate on negative stimuli). Leveraging Ilumivu technology from the Technology, Assessment, Data, and Analysis (TADA) Core, adolescents will then complete a short-term EMA burst design with two, 2-week, EMA protocols at baseline and at a 6-month follow-up, assessing “real-time” RNT and cardinal mood symptoms of a broad spectrum of mental health problems (e.g., depressed, anxious, irritable, and angry mood). Finally, participants will complete a second laboratory visit to reassess full spectrum mental health via self-report and interviews. Ultimately, this research will inform the development of technology deployed ecological momentary interventions (EMIs) or just-in-time adaptive interventions (JITAIs) that vary based on real-time needs (e.g., in-vivo RNT) and help prevent and curtail mental health problems following childhood adversity.

项目概要/摘要 COBRE 研究项目 1 将使项目负责人 Vergara-Lopez 能够收集试点数据，以支持竞争性 R01 应用程序，该应用程序调查儿童虐待对重复消​​极思维 (RNT) 的影响以及心理健康问题的风险。早年的逆境会改变认知过程；随着儿童进入青春期，这些影响变得更加明显。然而，童年逆境导致青少年精神病理学风险的认知机制尚不清楚。我们认为，认知控制缺陷，特别是处理情绪刺激时的设定转换不佳，会导致难以摆脱消极内容和重复消极思维（RNT）的体验。 RNT——一种以负面内容为重点的反复出现且难以控制的过程，已被提议作为跨内化（例如抑郁、焦虑）和外化（例如物质使用、攻击性）问题的跨诊断认知风险因素。然而，尚无研究探讨 RNT 在童年经历逆境的青少年体内发挥的作用。这是一个错失的重要临床机会，因为 RNT 可能作为广泛的心理健康问题的近端可塑性前因，因此成为潜在的跨诊断治疗目标。将从一项为期 12 年的纵向研究中招募接受过全面儿童保护服务并经过核实的虐待和其他逆境历史（通过情景压力访谈和自我/父母报告确定）的青少年。我们将利用这项纵向研究的基础设施，该研究通过多种方法、多信息评估对幼儿期（3-5 岁）和中期（9-11 岁）虐待的暴露类型、长期性和严重程度进行了丰富的虐待和其他不良暴露特征描述。我们将招募 15-17 岁的青少年和一名看护者。青少年 (N=75) 及其照顾者将参加实验室访问，通过诊断性临床访谈和自我报告措施评估心理健康状况。青少年将完成认知控制电池组，即 RNT 诱导与自由视角眼球追踪范例相结合，以评估摆脱负面内容的难度（即，参与者在视觉上停留或坚持负面刺激的程度）。利用技术、评估、数据和分析 (TADA) 核心的 Ilumivu 技术，青少年将完成短期 EMA 突发设计，在基线和 6 个月的随访中使用两次、两周的 EMA 方案，评估“实时”RNT 和广泛心理健康问题的主要情绪症状（例如抑郁、焦虑、易怒和愤怒情绪）。最后，参与者将完成第二次实验室访问，通过自我报告和访谈重新评估全方位的心理健康状况。最终，这项研究将为生态瞬时干预（EMI）或即时适应性干预（JITAI）技术的发展提供信息，这些技术根据实时需求（例如体内 RNT）而变化，并有助于预防和减少童年逆境后的心理健康问题。