Diversity Supplement for Kristina Bell: Biopsychosocial pain predictors of mobility decline in aging

克里斯蒂娜·贝尔的多样性补充：衰老过程中活动能力下降的生物心理社会疼痛预测因素

• 批准号: 10687327
• 负责人: Stephen Coombes
• 金额: $ 1.83万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-01 至 2027-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10687327
• 关键词: Age; Aging; Brain; Complex; Elderly; Individual; Joints; Knowledge; Longitudinal Studies; Measures; Mediating; Musculoskeletal Pain; Older Population; Pain; Pathology; Patient Self-Report; Peripheral; Predictive Factor; Prospective Studies; Research Design; Role; Shapes; Structure; Work; age related; aged; biopsychosocial; chronic musculoskeletal pain; disability impact; field study; novel; prospective; psychosocial

A. Project Summary or Abstract: Mobility disability impacts approximately 30% of individuals aged 60-69, 40% of individuals aged 70-79, and 55% of individuals age 80 or older. Emerging cross-sectional evidence suggests that self-reported musculoskeletal pain may be one of the major drivers of age-related mobility decline. Despite this evidence, significant knowledge gaps remain because the relationships among chronic musculoskeletal pain, aging, mobility, psychosocial function, and the brain have not been studied longitudinally in the same older individuals. Our prospective study design will provide novel information on the role of pain-related brain changes as predictive factors of age-related mobility decline. The proposed work will allow us to determine whether pain as well as brain structure and function predict mobility decline longitudinally (Aim 1) and whether brain measures mediate the pain-mobility association prospectively (Aim 2). The proposed work integrates multiple fields of study within a biopsychosocial approach to study pain and mobility in the older population.

A.项目摘要或摘要：行动不便影响大约30%的60-69岁的人，40% 年龄在70-79岁的人中，55%的人年龄在80岁或以上。新出现的横向证据表明， 自我报告的肌肉骨骼疼痛可能是与年龄相关的活动能力下降的主要驱动因素之一。尽管 这一证据表明，由于慢性肌肉骨骼疾病之间的关系， 疼痛、衰老、活动性、心理社会功能和大脑尚未在同一老年人中进行纵向研究。 个体我们的前瞻性研究设计将为疼痛相关的大脑变化的作用提供新的信息 作为与年龄相关的流动性下降的预测因素。这项工作将使我们能够确定疼痛是否 以及大脑结构和功能预测纵向移动性下降（目标1），以及大脑是否测量 前瞻性地介导疼痛-活动性关联（目的2）。拟议的工作整合了多个研究领域 在一个生物心理社会的方法来研究老年人的疼痛和流动性。