Cognitive SuperAging: A model to explore resilience and resistance to aging and Alzheimers disease
认知超级老化:探索对衰老和阿尔茨海默病的恢复力和抵抗力的模型
基本信息
- 批准号:10359727
- 负责人:
- 金额:$ 75.18万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-05-01 至 2025-01-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAgeAge-associated memory impairmentAgingAlzheimer&aposs DiseaseAlzheimer&aposs disease pathologyAlzheimer&aposs disease riskAnteriorAxonBiologicalBiometryBrainBrain DiseasesCessation of lifeCharacteristicsChronologyCognitionCognitiveCognitive agingCollaborationsConsequentialismDataDementiaDendritic SpinesElderlyEnrollmentEpisodic memoryEvaluationFundingGene ExpressionGeneticGenetic PolymorphismImmuneImmunohistochemistryIndividualInflammationLabelLateralLifeMAP2K3 geneMagnetic Resonance ImagingMaintenanceMeasuresMemoryMemory LossModelingMolecularNerve DegenerationNeurobiologyNeurocognitiveNeurofibrillary TanglesNeuronal PlasticityNeuronsNeuropsychologyNeurosciencesOutcomeParietal LobeParticipantPathway AnalysisPatternPerformancePhenotypePhysiologicalPositron-Emission TomographyProcessProteinsReportingResearchResearch PriorityResistanceRestRisk FactorsStructureSynapsesThinnessTimeTissuesUnited States National Institutes of HealthUniversitiesage relatedaging brainbasebehavioral neurologycingulate cortexcognitive neurosciencecognitive performancecognitive reservecohortdemographicsdensitydesignentorhinal cortexgene networkgraph theoryhuman old age (65+)impressionin vivoinsightlongitudinal designmultidisciplinaryneocorticalneuroimagingneuropathologynormal agingnovelpeerpreventprotective factorspsychosocialrecruitresilienceresistance mechanismsegregationtranscriptometranscriptome sequencingtranscriptomicswhite matter
项目摘要
PROJECT SUMMARY/ABSTRACT:
Memory complaints are widespread among the elderly and aging is a major risk factor for Alzheimer's disease
(AD), leading to the impression that a gradual loss of memory ability, eventually culminating in dementia, may
be a nearly universal consequence of getting old. Our studies explore an alternative aging trajectory by
studying 80+ year olds, who have episodic memory performance that appears to have escaped age-related
decline and that remains in the range that is at least normal for 50-60 year-olds and we have labelled
`SuperAgers'. We enrolled a dedicated and unique cohort of SuperAgers and Controls committed to
longitudinal assessment and brain donation at death. Our initial studies identified domain-specific biologic,
psychosocial, and genetic features of the SuperAgers, including maintenance of cortical integrity (especially in
the anterior cingulate), an abundance of anterior cingulate Von Economo neurons and sparse cortical
Alzheimer pathology compared to their cognitively average peers. These features may contribute in part to
maintenance of superior memory performance past the 8th decade of life. This Project plans to extend the
characterization of the SuperAging phenotype through hypothesis-driven novel evaluations of functional brain
network connectivity, regional distribution of gene expression, and integrity of dendritic, synaptic and axonal
markers. The proposed project will allow us to expand our unique group of SuperAgers and cognitively
average peers and address important questions related to the neurobiology of resilience and cognitive reserve.
By identifying neurobiologic features that contribute to superior memory performance in old age, outcomes
from this project will help isolate factors that promote successful cognitive aging and perhaps also prevent age-
related brain diseases such as AD. The project's reliance on a cohort that has already been partially recruited,
its longitudinal design, multidisciplinary structure, and collaboration-friendly organization increases the
likelihood that consequential progress will be achieved.
项目总结/文摘:
项目成果
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{{ truncateString('CHANGIZ GEULA', 18)}}的其他基金
Cognitive SuperAging: A model to explore resilience and resistance to aging and Alzheimers disease
认知超级老化:探索对衰老和阿尔茨海默病的恢复力和抵抗力的模型
- 批准号:
10901316 - 财政年份:2023
- 资助金额:
$ 75.18万 - 项目类别:
Study to Uncover Pathways to Exceptional Cognitive Resilience in Aging (SUPERAging)
研究揭示衰老过程中卓越认知弹性的途径(SUPERAging)
- 批准号:
10276525 - 财政年份:2021
- 资助金额:
$ 75.18万 - 项目类别:
Study to Uncover Pathways to Exceptional Cognitive Resilience in Aging (SUPERAging)
研究揭示衰老过程中卓越认知弹性的途径(SUPERAging)
- 批准号:
10687271 - 财政年份:2021
- 资助金额:
$ 75.18万 - 项目类别:
Characterized Adult Primary Human Microglia Cells for Research
用于研究的特征化成人原代人小胶质细胞
- 批准号:
10004183 - 财政年份:2018
- 资助金额:
$ 75.18万 - 项目类别:
Characterized Adult Primary Human Microglia Cells for Research
用于研究的特征化成人原代人小胶质细胞
- 批准号:
9788539 - 财政年份:2018
- 资助金额:
$ 75.18万 - 项目类别:
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