Integrated Health Sciences Facility Core

综合健康科学设施核心

• 批准号: 10689676
• 负责人: Debra MacKenzie
• 金额: $ 18.31万
• 依托单位: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-25 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10689676
• 关键词: Address; Animals; Basic Science; Biological; Cancer Biology; Cardiovascular Diseases; Clinical; Collaborations; Communicable Diseases; Communication; Communities; Community Health; Complex; Consultations; Core Facility; DNA Damage; DNA Repair; Data; Ensure; Environmental Exposure; Environmental Health; Environmental Science; Epidemiology; Gases; Goals; Health; Health Policy; Health Sciences; Human; Immunology; Individual; Infrastructure; Institution; Institutional Review Boards; Knowledge; Laboratories; Metal exposure; Metals; Mexico; Mining; Molecular Toxicology; National Institute of Environmental Health Sciences; New Mexico; Nutritional Science; Oils; Outcome; Pharmacologic Substance; Population; Predisposition; PubMed; Public Health; Publications; Research; Research Design; Research Personnel; Research Support; Resources; Respiratory Disease; Risk Factors; Sampling; Science; Services; Site; Source; Toxicology; Translational Research; Uranium; Work; commune; design; experience; hydraulic fracturing; innovation; instrumentation; interest; member; metabolomics; neurodevelopment; programs; research study; response; text searching; translational research program; translational study; tribal community; wasting

IHSFC PROJECT SUMMARY Within the state of New Mexico, the health impacts (both individual and communal) from mining, metal exposure as well as oil/gas/fracking activities are of considerable community concern. There is a broad range of experience and extensive depth of knowledge that exists among the researchers and research teams throughout the NM-INSPIRES Center investigators that can be directed toward addressing these community environmental health concerns. The overall goal of the IHSFC is to work in partnership with all the Center’s Cores and provide key infrastructure and support to actualize innovative translational and reverse translational environmental health research that serves the communities of New Mexico. Environmental health research currently conducted by NM-INSPIRES investigators generates data on a large number of variables including environmental exposures, intermediate biological responses, and complex health outcomes. The findings from this broad array of ongoing environmental, human and animal studies provides a rich source of data to inform and inspire new translational or reverse-translational studies addressing complex exposure-outcome relationships. The IHSFC will support the expansion and implementation of new translational and reverse-translational research and capitalizes on the broad experience that exists within the Center. The IHSFC team includes expertise in epidemiology, public health and toxicology to provide guidance for study design to effectively address population risk factors and susceptibilities as well as potential mechanisms that drive health outcomes. Specifically, the IHSFC will provide exceptional and complementary scientific, technical and operational support to facilitate both new collaborations and initiatives through 1) providing support for study design and implementation of population, clinical and laboratory based studies, 2) overcoming institutional or regulatory bottlenecks, 3) facilitating access to existing data and samples from ongoing environmental research to support or validate new initiatives. The specific experience within the IHSFC team in implementing translational research studies will provide an infrastructure that does not currently exist across the Center. The IHSFC will work to capitalize on the unique research background and experience within the NM INSPIRES Center to expand our reach more broadly across New Mexico and build on the strength of existing expertise, available resources to develop the infrastructure and create a value- added synergistic service that will achieve Center objectives. The services and support provided by the IHSFC provides a mechanism to continue to expand our excellent basic and translational research programs in environmental health to serve our diverse community.

IHSFC项目摘要 在新墨西哥州，在采矿，金属中，健康影响（个人和公共） 暴露以及石油/天然气/压裂活动引起了人们的关注。范围很广 研究人员和研究团队之间存在的经验和广泛的知识 在整个NM启发中心的调查人员中，可以致力于解决这些社区 环境健康问题。 IHSFC的总体目标是与该中心的所有 核心并提供关键的基础架构和支持，以实现创新的翻译和反向 为新墨西哥州社区提供服务的转化环境健康研究。环境的 NM-Inspires研究人员目前进行的健康研究生成了有关大量的数据 变量包括环境暴露，中间的生物反应和复杂的健康 结果。从这个广泛的环境中，人类和动物研究的发现提供了 丰富的数据来源，以告知和激发新的翻译或反向翻译研究，以解决复杂 暴露结果关系。 IHSFC将支持新的扩展和实施 翻译和反向翻译研究，并利用 中心。 IHSFC团队包括流行病学，公共卫生和毒理学专业知识，以提供指导 为了进行研究设计，可以有效解决人口风险因素和敏感性以及潜力 推动健康结果的机制。具体而言，IHSFC将提供出色和完整的 科学，技术和运营支持，以促进新的合作和倡议1） 为人口，临床和实验室研究的研究设计和实施提供支持，2） 克服机构或监管瓶颈，3）支持从 正在进行的环境研究以支持或验证新计划。内部的特定经验 IHSFC团队实施转化研究将提供一个基础架构 目前存在于中心。 IHSFC将努力利用独特的研究背景和 NM中的经验激发了中心，以更广泛地在新墨西哥州扩大我们的影响力并建造 关于现有专业知识的实力，可用的资源来开发基础架构并创建价值 - 添加了协同服务将实现中心目标。由 IHSFC提供了一种继续扩展我们出色的基本和翻译的研究计划的机制 在环境健康方面为我们的潜水员社区服务。