Integrated Health Sciences Facility Core

综合健康科学设施核心

• 批准号: 10689676
• 负责人: Debra MacKenzie
• 金额: $ 18.31万
• 依托单位: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-25 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10689676
• 关键词: Address; Animals; Basic Science; Biological; Cancer Biology; Cardiovascular Diseases; Clinical; Collaborations; Communicable Diseases; Communication; Communities; Community Health; Complex; Consultations; Core Facility; DNA Damage; DNA Repair; Data; Ensure; Environmental Exposure; Environmental Health; Environmental Science; Epidemiology; Gases; Goals; Health; Health Policy; Health Sciences; Human; Immunology; Individual; Infrastructure; Institution; Institutional Review Boards; Knowledge; Laboratories; Metal exposure; Metals; Mexico; Mining; Molecular Toxicology; National Institute of Environmental Health Sciences; New Mexico; Nutritional Science; Oils; Outcome; Pharmacologic Substance; Population; Predisposition; PubMed; Public Health; Publications; Research; Research Design; Research Personnel; Research Support; Resources; Respiratory Disease; Risk Factors; Sampling; Science; Services; Site; Source; Toxicology; Translational Research; Uranium; Work; commune; design; experience; hydraulic fracturing; innovation; instrumentation; interest; member; metabolomics; neurodevelopment; programs; research study; response; text searching; translational research program; translational study; tribal community; wasting

IHSFC PROJECT SUMMARY Within the state of New Mexico, the health impacts (both individual and communal) from mining, metal exposure as well as oil/gas/fracking activities are of considerable community concern. There is a broad range of experience and extensive depth of knowledge that exists among the researchers and research teams throughout the NM-INSPIRES Center investigators that can be directed toward addressing these community environmental health concerns. The overall goal of the IHSFC is to work in partnership with all the Center’s Cores and provide key infrastructure and support to actualize innovative translational and reverse translational environmental health research that serves the communities of New Mexico. Environmental health research currently conducted by NM-INSPIRES investigators generates data on a large number of variables including environmental exposures, intermediate biological responses, and complex health outcomes. The findings from this broad array of ongoing environmental, human and animal studies provides a rich source of data to inform and inspire new translational or reverse-translational studies addressing complex exposure-outcome relationships. The IHSFC will support the expansion and implementation of new translational and reverse-translational research and capitalizes on the broad experience that exists within the Center. The IHSFC team includes expertise in epidemiology, public health and toxicology to provide guidance for study design to effectively address population risk factors and susceptibilities as well as potential mechanisms that drive health outcomes. Specifically, the IHSFC will provide exceptional and complementary scientific, technical and operational support to facilitate both new collaborations and initiatives through 1) providing support for study design and implementation of population, clinical and laboratory based studies, 2) overcoming institutional or regulatory bottlenecks, 3) facilitating access to existing data and samples from ongoing environmental research to support or validate new initiatives. The specific experience within the IHSFC team in implementing translational research studies will provide an infrastructure that does not currently exist across the Center. The IHSFC will work to capitalize on the unique research background and experience within the NM INSPIRES Center to expand our reach more broadly across New Mexico and build on the strength of existing expertise, available resources to develop the infrastructure and create a value- added synergistic service that will achieve Center objectives. The services and support provided by the IHSFC provides a mechanism to continue to expand our excellent basic and translational research programs in environmental health to serve our diverse community.

IHSFC项目总结 在新墨西哥州内，采矿、金属加工、采矿业和采矿业对健康的影响（个人和社区） 暴露以及石油/天然气/水力压裂活动是社区相当关注的问题。有一个广泛的范围 研究人员和研究团队的经验和广泛的知识深度 整个NM-INSPIRES中心的研究人员可以直接针对这些社区 环境健康问题。IHSFC的总体目标是与所有中心的 核心并提供关键的基础设施和支持，以实现创新的转化和逆转 为新墨西哥州社区服务的转化环境健康研究。环境 目前由NM-INSPIRES研究人员进行的健康研究产生了大量的数据， 变量包括环境暴露、中间生物反应和复杂的健康状况 结果。这些正在进行的环境、人类和动物研究的结果提供了一个 丰富的数据来源，为解决复杂问题提供信息和启发新的翻译或反向翻译研究 结果-结果关系。IHSFC将支持扩展和实施新的 翻译和反向翻译研究，并利用广泛的经验，存在于 中心IHSFC团队包括流行病学，公共卫生和毒理学方面的专业知识， 对于研究设计，以有效解决人群风险因素和易感性以及潜在的 推动健康成果的机制。具体而言，IHSFC将提供特殊和互补的 科学、技术和业务支持，以促进新的合作和举措，具体做法是： 为研究设计和实施人群、临床和实验室研究提供支持，2） 克服体制或监管瓶颈，3）便利获取现有数据和样本， 正在进行的环境研究，以支持或验证新的倡议。具体经验在 IHSFC团队在实施转化研究时将提供不需要的基础设施 目前存在于整个中心。IHSFC将努力利用独特的研究背景， 在NM INSPIRES中心的经验，以扩大我们的覆盖范围更广泛地跨越新墨西哥州，并建立 利用现有的专业知识和可用资源来开发基础设施并创造价值- 增加了将实现中心目标的协同服务。提供的服务和支持， IHSFC提供了一个机制，继续扩大我们优秀的基础和转化研究计划 为我们多元化的社区服务。