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Affective and Neural Correlates of Nicotine and Cannabis Co-Use in Young Adulthood

青年期尼古丁和大麻共同使用的情感和神经相关性

基本信息

批准号：
10689715
负责人：
Julia May Brooks
金额：
$ 4.77万
依托单位：
UNIVERSITY OF ILLINOIS AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-08-19 至 2024-08-18
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10689715
关键词：
Address Affect Affective Age Behavioral Cannabis Data Analyses Dedications Dependence Development Dopamine Drug usage Ecological momentary assessment Educational workshop Electroencephalography Ethics Future Goals Grant Individual Individual Differences Intervention Knowledge Laboratories Life Link Maintenance Manuscripts Measures Mental Health Mentors Mentorship Methods Moods Nicotine Outcome Participant Pattern Pharmaceutical Preparations Phenotype Population Prevalence Prevention Psyche structure Psychological reinforcement Public Health Reporting Research Research Personnel Rewards Risk Sampling Statistical Data Interpretation Statistical Methods Stimulus Techniques Testing Time Tobacco Tobacco use Training Visit Work Writing age group career career development drug maintenance experience high risk marijuana use marijuana user neural neural correlate nicotine use nicotine user psychologic recruit response responsible research conduct reward circuitry substance use symposium tobacco products transmission process young adult

项目摘要

PROJECT SUMMARY/ABSTRACT Co-use of tobacco and cannabis is increasingly prevalent and may be associated with greater physical and psychological risks when compared to use of either substance alone. Co-use is particularly prevalent in young adulthood, an age group where risk for problematic substance use is heightened. Despite growing rates of co-use in this age group, factors that may maintain co-use are less well known. Individual differences in positive affect response to drug use and neural reward reactivity are important predictors of drug use maintenance, but are relatively understudied in this population. Thus, the specific aims of the proposed study are to 1) Characterize subjective positive affect response to cannabis and nicotine co-use, as compared to single- use of either substance 2) Investigate relationships between non-intoxicated neural reward reactivity and positive affect response following episodes of cannabis, nicotine, and co-use, and 3) Examine rates of cannabis and nicotine use in the past month as potential moderators of the relationship between non-intoxicated neural reward reactivity and positive affect change following drug use. To address these aims, the current study proposes to recruit a subset of participants from a large-scale ecological momentary assessment (EMA) study of young adult cannabis and tobacco co-users to participate in an additional electroencephalogram (EEG) laboratory visit. These study aims support the applicant’s training goals to 1) develop knowledge in phenotypes of concurrent substance use through investigating affective, neural, and behavioral correlates of nicotine and cannabis co-use 2) acquire training in EMA methods and data analysis 3) gain training and experience in EEG methods 4) pursue academic professional development through authoring manuscripts, conference presentations, and career development and grant writing seminars and workshops, and 5) gain training in ethics and responsible conduct of research. The applicant’s mentorship team is comprised of experts in young adult nicotine and cannabis use research and EMA methods (Dr. Mermelstein), affective and neural correlates of cannabis use in young adulthood (Dr. Crane), EEG methods and analysis (Dr. Burkhouse), and advanced statistical methods (Dr. Hedeker). The mentoring team will thus advance the applicant’s goals to pursue training in concurrent substance use research, EMA methods, and EEG methods. The proposed training and research plan ultimately supports the candidate’s long-term goal of pursuing a career as an independent investigator dedicated to understanding affective, behavioral, and neural correlates of concurrent substance use in young adulthood. Further, the proposed study has the potential to greatly advance our understanding of correlates of affective and neural correlates co-use in young adulthood that can be harnessed as future prevention and treatment targets.

项目总结/摘要烟草和大麻的共同使用越来越普遍，可能与更大的身体健康有关。与单独使用任何一种物质相比，共同使用特别普遍，青年人，这一年龄组使用问题药物的风险较高。尽管增长率在这一年龄组的共同使用，可能维持共同使用的因素不太为人所知。的个体差异对药物使用的积极情感反应和神经奖赏反应是药物使用的重要预测因子维持，但在这一人群中相对研究不足。因此，拟议研究的具体目标 1）与单一使用相比，表征对大麻和尼古丁共同使用的主观积极情感反应， 2）研究非中毒性神经奖励反应与阳性反应之间的关系。影响大麻、尼古丁和共同使用事件后的反应，以及3）检查大麻和尼古丁使用在过去的一个月内作为非中毒神经奖励之间的关系的潜在调节剂反应性和积极的影响变化后，药物使用。为了实现这些目标，本研究建议：从一项针对年轻成年人的大规模生态瞬时评估（EMA）研究中招募一部分参与者，大麻和烟草共同使用者参加额外的脑电图（EEG）实验室访视。这些研究目的支持申请人的培训目标：1）发展并发症表型知识，通过调查尼古丁和大麻共同使用的情感，神经和行为相关性来研究物质使用 2)获得EMA方法和数据分析的培训3）获得EEG方法的培训和经验4）追求通过撰写手稿，会议演讲和职业生涯的学术专业发展发展和赠款写作研讨会和讲习班，以及5）获得道德和负责任行为的培训的研究。申请人的导师团队由年轻成人尼古丁和大麻使用专家组成研究和EMA方法（Mermelstein博士），年轻人使用大麻的情感和神经相关性成年（起重机博士），脑电图方法和分析（伯克豪斯博士），和先进的统计方法（博士。 Hedeker）。因此，辅导小组将推进申请人的目标，以寻求同时进行实质性培训使用研究、EMA方法和EEG方法。拟议的培训和研究计划最终支持候选人的长期目标是追求职业生涯作为一个独立的调查员致力于了解情感，行为和神经相关的并发物质使用在年轻的成年。此夕h 这项研究有可能极大地促进我们对情感和神经相关性的理解。与青年期的共同使用相关，可作为未来的预防和治疗目标。