Colorado HNC SPORE Biospecimen/Pathology Core

摘要，BPC 生物学家/病理学核心(BPC)是为支持以下工作而建立的中央标本存储库 头颈癌(HNC)孢子，以帮助成功执行拟议的研究。穿过 我们将建立一个全面的组织标本、体液和组织分离资源 (DNA/RNA)，它将支持孢子，并可被外部调查人员用来改善我们的 了解头颈部病变发生、发展和发展的潜在机制 癌症和改善治疗选择，以帮助临床医生进行病人管理。《战略规划纲要》的主要目标 是获取、表征、分析、加工和分发标本。这些服务的提供 利用与现有设施、基础设施和人员的密切工作关系 科罗拉多大学癌症中心组织生物库和组织学操作 处理共享资源和科罗拉多大学生物库核心设施。标本是 收集作为档案组织或孢子试验相关标本，根据IRB批准获得 协议。BPC还将收集相关的临床和生物学信息，这些信息可以包括在样本中 分配。BPC提供组织学解释，进行免疫组织化学(IHC)和 通过图像分析定量IHC，制备生物样品分离株(RNA，DNA，蛋白质)，并提供 对孢子项目所需的选定标本进行分子分析。这包括组织学检查和 按最新公布的WHO分类系统分类，以病理学家为首。这个 CORE设计其活动以满足提案中概述的每一个孢子项目的需要。按顺序 为了满足组织需求和实现项目的目标，BPC收集和处理组织在 通过与项目调查人员合作确定的具体方式。BPC还在 执行与项目相关的研究，其中BPC人员的专业知识可以帮助研究设计、数据 生成和数据分析。BPC将提供必要的经验和专业知识，以便能够 开发CLIA认证的测试，将研究成果转化为临床实用。

SUMMARY, BPC The Biospecimen/Pathology Core (BPC) is the central repository of specimens established to provide support to the Head and Neck Cancer (HNC) SPORE to aid in the successful execution of the proposed studies. Through the BPC we will establish a comprehensive resource of tissue specimens, body fluids, and tissue isolates (DNA/RNA) that will support the SPORE and can be used by extramural investigators to improve our understanding of the underlying mechanisms in the onset, development, and progression of head and neck cancer and improve treatment options to aid the clinician in patient management. The main goals of the BPC are to procure, characterize, analyze and process, and distribute specimen. The provision of these services takes advantage of a close working relationship with the existing facilities, infrastructure, and personnel for biobanking and histology operations of the University of Colorado Cancer Center Tissue Biobanking and Processing Shared Resource and the University of Colorado Biorepository Core Facility. Specimens are collected as archival tissue or SPORE trial associated specimens that are obtained under IRB approved protocols. The BPC will also collect correlative clinical and biologic information that can be included in specimen distributions. The BPC provides histologic interpretation, performs immunohistochemistry (IHC) and quantification of IHC by image analysis, prepares biospecimen isolates (RNA, DNA, protein), and provides molecular analysis on selected specimens required by the SPORE projects. This includes histologic review and classification by up-to-date published WHO classification systems by the pathologist leadership of the core. The core designs its activities to meet the needs of each of the SPORE projects as outlined in the proposal. In order to meet the tissue needs and achieve the goals of the projects, the BPC collects and processes tissues in a specific manner as determined via collaboration with project investigators. The BPC also collaborates in the performance of project related studies in which expertise of BPC personnel can benefit study design, data generation, and data analysis. The BPC will provide the necessary experience and expertise to be able to develop CLIA certified testing to translate research findings into clinical utility.