MAPP Research Network Tissue Analysis and Technology Core

描述（由申请人提供）：这是一份来自组织分析和技术中心（TATC）的申请，该中心目前位于科罗拉多大学安舒茨医学院（UCAMC），旨在继续参与MAPP研究网络（RN），以响应2013年8月23日分发的RFA-DK-13-507。TATC的主要职责是通过在以下领域提供专业知识和服务来支持trans-MAPP纵向症状模式研究（SPS）：1）用于trans-MAPP蛋白质组学、感染性病因学和基因组学研究的生物标本采集、处理、管理和分发，2）集中ELISA和分析物检测，包括蛋白质和肌酐定量以及MAPP生物标本的质量控制检测，和3）trans-MAPP群组的集中基因分型。TATC将作为MAPP SPS期间采集的所有体液标本的储存库;使用定制、质量控制和记录的最佳实践程序处理这些标本;并将这些生物标本提供给MAPP研究者，以满足MAPP RN的目标。TATC将与MAPP数据协调中心（DCC）和执行委员会密切合作，以确保成功实现MAPP RN的目标。TATC将符合所有NIH质量标准，并将根据IRB、HIPAA和NIDDK程序向研究人员提供标本，这些程序保护所有同意存档组织和血液的患者的机密性。根据RFP中规定的条款，TATC将准备来自MAPP RN的所有残留样品，以转移至NIDDK中央生物储存库。TATC将与NIDDK中央生物储存库合作，按照NIDDK的指示协调收集、编码、储存和最终转移的程序。

DESCRIPTION (provided by applicant): This is an application from the Tissue Analysis and Technology Core (TATC), currently housed at the University of Colorado Anschutz Medical Campus (UCAMC), to continue participation in the MAPP Research Network (RN) in response to RFA-DK-13-507 circulated on 8/23/2013. The primary responsibilities of the TATC will be to support the trans-MAPP longitudinal Symptom Patterns Study (SPS) by providing expertise and services in the areas of 1) biospecimens collection, processing, management and distribution for trans-MAPP proteomic, infectious etiology, and genomic studies, 2) centralized ELISA and analyte testing including protein and creatinine quantifications and quality control testing on MAPP biospecimens, and 3) centralized genotyping of the trans-MAPP cohort. The TATC will serve as the repository for all body fluid specimens collected during the MAPP SPS; process these specimens using customized, quality controlled, and documented best practice procedures; and to provide these biospecimens to MAPP investigators to meet the objectives of the MAPP RN. The TATC will collaborate closely with the MAPP Data Coordinating Center (DCC) and Executive Committee to ensure that the goals of the MAPP RN are successfully met. The TATC will meet all NIH quality standards and will provide specimens to researchers according to IRB, HIPAA and NIDDK procedures that protect the confidentiality of all consented patients whose tissue and blood are archived. In accordance with the terms set forth in the RFP, the TATC will prepare all residual samples from the MAPP RN for transfer to the NIDDK Central Biorepository. The TATC will work with the NIDDK Central Biorepository to coordinate procedures for collection, coding, storage and eventual transfer as directed by the NIDDK.