MAPP Research Network Tissue Analysis and Technology Core

描述(由申请人提供)：这是一份组织分析与技术核心(TATC)的申请，目前位于科罗拉多大学安舒茨医学院(UCAMC)，根据2013年8月23日分发的RFA-DK-13-507，继续参与MAPP研究网络(RN)。TATC的主要职责将是支持跨MAPP纵向症状模式研究(SPS)，提供以下领域的专业知识和服务：1)跨MAPP蛋白质组、感染病因学和基因组研究的生物样本收集、处理、管理和分配；2)集中式ELISA法和分析测试，包括MAPP生物样本的蛋白质和肌酐定量以及质量控制测试；以及3)跨MAPP队列的集中基因分型。TATC将作为MAPP SPS期间收集的所有体液样本的储存库；使用定制的、质量受控的和有文件记录的最佳实践程序处理这些样本；并向MAPP调查人员提供这些生物标本，以满足MAPP RN的目标。TATC将与MAPP数据协调中心(DCC)和执行委员会密切合作，以确保成功实现MAPP RN的目标。TATC将符合所有NIH质量标准，并将根据IRB、HIPAA和NIDDK程序向研究人员提供样本，这些程序保护所有同意的组织和血液存档的患者的机密性。根据RFP中规定的条款，TATC将准备来自MAPP RN的所有剩余样本，以便转移到NIDDK中央生物库。TATC将与NIDDK中央生物库合作，按照NIDDK的指示协调收集、编码、储存和最终转移的程序。

DESCRIPTION (provided by applicant): This is an application from the Tissue Analysis and Technology Core (TATC), currently housed at the University of Colorado Anschutz Medical Campus (UCAMC), to continue participation in the MAPP Research Network (RN) in response to RFA-DK-13-507 circulated on 8/23/2013. The primary responsibilities of the TATC will be to support the trans-MAPP longitudinal Symptom Patterns Study (SPS) by providing expertise and services in the areas of 1) biospecimens collection, processing, management and distribution for trans-MAPP proteomic, infectious etiology, and genomic studies, 2) centralized ELISA and analyte testing including protein and creatinine quantifications and quality control testing on MAPP biospecimens, and 3) centralized genotyping of the trans-MAPP cohort. The TATC will serve as the repository for all body fluid specimens collected during the MAPP SPS; process these specimens using customized, quality controlled, and documented best practice procedures; and to provide these biospecimens to MAPP investigators to meet the objectives of the MAPP RN. The TATC will collaborate closely with the MAPP Data Coordinating Center (DCC) and Executive Committee to ensure that the goals of the MAPP RN are successfully met. The TATC will meet all NIH quality standards and will provide specimens to researchers according to IRB, HIPAA and NIDDK procedures that protect the confidentiality of all consented patients whose tissue and blood are archived. In accordance with the terms set forth in the RFP, the TATC will prepare all residual samples from the MAPP RN for transfer to the NIDDK Central Biorepository. The TATC will work with the NIDDK Central Biorepository to coordinate procedures for collection, coding, storage and eventual transfer as directed by the NIDDK.