MAPP Research Network Tissue Analysis and Technology Core

描述（由申请人提供）：这是一份来自组织分析和技术核心（TATC）的申请，目前位于科罗拉多大学安舒茨医学院（UCAMC），为了响应2013年8月23日发布的RFA-DK-13-507，继续参与MAPP研究网络（RN）。TATC的主要职责是通过在以下领域提供专业知识和服务来支持跨MAPP纵向症状模式研究（SPS）： 1)跨MAPP蛋白质组学、感染病因学和基因组学研究的生物标本收集、处理、管理和分发；2)集中ELISA和分析物检测，包括蛋白质和肌酐定量以及MAPP生物标本的质量控制测试；3)跨mapp队列的集中基因分型。TATC将作为MAPP SPS期间收集的所有体液标本的储存库；使用定制的、质量控制的、有文件记录的最佳实践程序处理这些标本；并向MAPP调查员提供这些生物标本，以满足MAPP RN的目标。TATC将与MAPP数据协调中心（DCC）和执行委员会密切合作，确保MAPP RN的目标成功实现。TATC将符合所有NIH质量标准，并将根据IRB， HIPAA和NIDDK程序向研究人员提供标本，这些程序保护所有同意患者的组织和血液的机密性。根据RFP中规定的条款，TATC将准备来自MAPP RN的所有剩余样品，以便转移到NIDDK中央生物库。技术咨询中心将与NIDDK中央生物库合作，按照NIDDK的指示协调收集、编码、存储和最终转移的程序。

DESCRIPTION (provided by applicant): This is an application from the Tissue Analysis and Technology Core (TATC), currently housed at the University of Colorado Anschutz Medical Campus (UCAMC), to continue participation in the MAPP Research Network (RN) in response to RFA-DK-13-507 circulated on 8/23/2013. The primary responsibilities of the TATC will be to support the trans-MAPP longitudinal Symptom Patterns Study (SPS) by providing expertise and services in the areas of 1) biospecimens collection, processing, management and distribution for trans-MAPP proteomic, infectious etiology, and genomic studies, 2) centralized ELISA and analyte testing including protein and creatinine quantifications and quality control testing on MAPP biospecimens, and 3) centralized genotyping of the trans-MAPP cohort. The TATC will serve as the repository for all body fluid specimens collected during the MAPP SPS; process these specimens using customized, quality controlled, and documented best practice procedures; and to provide these biospecimens to MAPP investigators to meet the objectives of the MAPP RN. The TATC will collaborate closely with the MAPP Data Coordinating Center (DCC) and Executive Committee to ensure that the goals of the MAPP RN are successfully met. The TATC will meet all NIH quality standards and will provide specimens to researchers according to IRB, HIPAA and NIDDK procedures that protect the confidentiality of all consented patients whose tissue and blood are archived. In accordance with the terms set forth in the RFP, the TATC will prepare all residual samples from the MAPP RN for transfer to the NIDDK Central Biorepository. The TATC will work with the NIDDK Central Biorepository to coordinate procedures for collection, coding, storage and eventual transfer as directed by the NIDDK.