Colorado HNC SPORE Biospecimen/Pathology Core

科罗拉多州 HNC SPORE 生物样本/病理学核心

• 批准号: 10268844
• 负责人: M. Scott Lucia
• 金额: $ 23.57万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10268844
• 关键词: Archives; Biological; Biological Specimen Banks; Body Fluids; CLIA certified; Cancer Center; Chemopreventive Agent; Classification; Clinical; Clinical Trials; Collaborations; Colorado; Computer Assisted; Consent; Core Facility; Cytogenetics; DNA; Data; Data Analyses; Data Science Core; Databases; Development; Diagnostic; Disease; Disease Progression; Drug or chemical Tissue Distribution; Extramural Activities; Generations; Genetic; Goals; Guidelines; Head Cancer; Head and Neck Cancer; Health Insurance Portability and Accountability Act; Histologic; Histology; Human; Human Resources; Image; Image Analysis; Immune; Immunohistochemistry; Immunologic Monitoring; Individual; Infrastructure; Institutional Review Boards; Intervention; Knowledge; Laboratories; Leadership; Link; Liquid substance; Medical; Methodology; Molecular; Molecular Analysis; Morphology; Outcome; Participant; Pathologic; Pathologist; Pathology; Patients; Performance; Practice Guidelines; Procedures; Process; Proteins; Protocols documentation; Publishing; RNA; Research; Research Design; Research Personnel; Resource Sharing; Resources; Service provision; Services; Solid; Specimen; Specimen Handling; Standardization; System; Techniques; Technology; Testing; The University of Colorado Cancer Center; Therapeutic; Time; Tissue Sample; Tissues; Translating; Translational Research; United States National Institutes of Health; Universities; Work; biobank; biological specimen archives; cancer clinical trial; career development; design; experience; human tissue; improved; laser capture microdissection; member; molecular pathology; operation; organizational structure; patient derived xenograft model; prevent; research study; response; skills; success; thyroid neoplasm; tissue archive; tissue processing; tissue resource; tool

SUMMARY, BPC The Biospecimen/Pathology Core (BPC) is the central repository of specimens established to provide support to the Head and Neck Cancer (HNC) SPORE to aid in the successful execution of the proposed studies. Through the BPC we will establish a comprehensive resource of tissue specimens, body fluids, and tissue isolates (DNA/RNA) that will support the SPORE and can be used by extramural investigators to improve our understanding of the underlying mechanisms in the onset, development, and progression of head and neck cancer and improve treatment options to aid the clinician in patient management. The main goals of the BPC are to procure, characterize, analyze and process, and distribute specimen. The provision of these services takes advantage of a close working relationship with the existing facilities, infrastructure, and personnel for biobanking and histology operations of the University of Colorado Cancer Center Tissue Biobanking and Processing Shared Resource and the University of Colorado Biorepository Core Facility. Specimens are collected as archival tissue or SPORE trial associated specimens that are obtained under IRB approved protocols. The BPC will also collect correlative clinical and biologic information that can be included in specimen distributions. The BPC provides histologic interpretation, performs immunohistochemistry (IHC) and quantification of IHC by image analysis, prepares biospecimen isolates (RNA, DNA, protein), and provides molecular analysis on selected specimens required by the SPORE projects. This includes histologic review and classification by up-to-date published WHO classification systems by the pathologist leadership of the core. The core designs its activities to meet the needs of each of the SPORE projects as outlined in the proposal. In order to meet the tissue needs and achieve the goals of the projects, the BPC collects and processes tissues in a specific manner as determined via collaboration with project investigators. The BPC also collaborates in the performance of project related studies in which expertise of BPC personnel can benefit study design, data generation, and data analysis. The BPC will provide the necessary experience and expertise to be able to develop CLIA certified testing to translate research findings into clinical utility.

摘要、业务流程控制 生物样本/病理学核心 (BPC) 是样本的中央存储库，旨在为以下人员提供支持： 头颈癌 (HNC) SPORE 有助于成功执行拟议的研究。通过 BPC 我们将建立组织标本、体液和组织分离物的综合资源 （DNA/RNA）将支持 SPORE，并且可以被校外研究人员用来改进我们的研究 了解头颈部发病、发展和进展的潜在机制 癌症并改善治疗方案，以帮助临床医生进行患者管理。 BPC 的主要目标 是采购、表征、分析和处理以及分发样本。提供这些服务 利用与现有设施、基础设施和人员的密切工作关系 科罗拉多大学癌症中心组织生物样本库和组织学业务 处理共享资源和科罗拉多大学生物样本库核心设施。标本是 作为档案组织或 SPORE 试验相关标本收集，并根据 IRB 批准获得 协议。 BPC 还将收集可包含在样本中的相关临床和生物学信息 分布。 BPC 提供组织学解释、执行免疫组织化学 (IHC) 和 通过图像分析对 IHC 进行定量，制备生物样本分离物（RNA、DNA、蛋白质），并提供 对 SPORE 项目所需的选定样本进行分子分析。这包括组织学检查和 分类采用最新公布的WHO分类系统，由病理学家领导为核心。这 core 设计其活动以满足提案中概述的每个 SPORE 项目的需求。为了 为了满足组织需求并实现项目目标，BPC 在一个特定的环境中收集和处理组织 具体方式由与项目调查人员合作确定。 BPC 还在以下领域开展合作： 执行与项目相关的研究，其中 BPC 人员的专业知识可以使研究设计、数据受益 生成和数据分析。 BPC 将提供必要的经验和专业知识，以便能够 开发 CLIA 认证测试，将研究成果转化为临床实用性。