Coordination Core

协调核心

• 批准号: 10704486
• 负责人: RICHARD M CAPRIOLI
• 金额: $ 21.32万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-30 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10704486
• 关键词: 3-Dimensional; Achievement; Atlases; Biological; Biomedical Research; Collaborations; Communication; Communities; Data; Data Analyses; Eye; Foundations; Freezing; Goals; High Performance Computing; Human; Human BioMolecular Atlas Program; Imaging technology; Infrastructure; Institution; Laboratories; Leadership; Manuscripts; Mass Spectrum Analysis; Mining; Mission; Molecular; Multimodal Imaging; Organ; Pancreas; Physicians; Procedures; Productivity; Protocols documentation; Publications; Publishing; Reporting; Research; Research Activity; Research Personnel; Resources; Role; Sampling; Scientific Evaluation; Scientist; Site; Specimen; Time; Tissue Banks; Tissue atlas; Travel; United States National Institutes of Health; Universities; Visualization; Work; biocomputing; complex data; data exchange; data management; data mining; data sharing; design; development policy; experience; flexibility; human tissue; imaging facilities; large scale data; meetings; member; molecular imaging; multidisciplinary; multimodality; operation; professional atmosphere; programs; skills; success; tissue fixing; tissue mapping; tool

PROJECT SUMMARY – Coordination Core. The proposed multidisciplinary Eye and Pancreas Tissue Mapping Center (TMC) for the Human BioMolecular Atlas Program (HuBMAP) requires diverse proficiencies including (1) the biological expertise and infrastructure required for acquisition of normal human tissue, (2) the analytical skills to produce highly multiplexed multimodal molecular imaging data, (3) computational expertise in integrating and mining complex data, and (4) a track record in collaboration between the TMC components and other HuBMAP consortium members. The Coordination Core (CC) will be a key center of administration for the proposed Vanderbilt University Eye and Pancreas Tissue Mapping Center (TMC). The specific aims of the CC directly reflect its role to prioritize achievement of program milestones through effective leadership, sharing of data and samples, and communication with HuBMAP leadership as well as interaction among Consortium groups to provide a foundation of success for the Vanderbilt Eye and Pancreas TMC. Leadership for the proposed TMC include distinguished experts in their fields: Dr. Jeffrey Spraggins (MPI, BIOMIC Director, DAC Team Leader), Dr. Richard Caprioli (MPI, CC Team Leader), Dr. Alvin Powers (MPI, Pancreas OSP Team Leader), and Dr. Kevin Schey (MPI, Eye OSP co-Team Leader). These four have worked extensively together in rigorous and large-scale research programs, for which they have managed research activities, collaborations, and data coordination. To contribute productively to the HuBMAP consortium, the proposed Vanderbilt Eye and Pancreas TMC will share and accept protocols, samples, and data to promote and unify 3-D molecular atlas construction across the Consortium. The Vanderbilt team will follow and participate in the development of policies and procedures established by the Consortium, including those for data/specimen sharing and publications. The overall mission of the CC and for the proposed TMC is to successfully contribute to HuBMAP to establish 3-D molecular human tissue atlases that advance biomedical research.

项目摘要-协调核心。拟议的多学科眼和胰腺组织映射 中心（TMC）的人类生物分子图谱计划（HuBMAP）需要不同的专业知识，包括（1） 获取正常人体组织所需的生物学专业知识和基础设施，（2）分析技能 产生高度多路复用的多模态分子成像数据，（3）整合和 挖掘复杂数据，以及（4）TMC组件与其他HuBMAP之间的协作记录 财团成员。协调核心（CC）将是拟议的 范德比尔特大学眼部和胰腺组织绘图中心（TMC）。CC的具体目标直接 反映其通过有效领导、数据共享和 样本，与HuBMAP领导层的沟通以及联盟团体之间的互动， 为范德比尔特眼科和胰腺TMC提供成功的基础。拟议TMC的领导层 包括各自领域的杰出专家：Jeffrey Spraggins博士（MPI，BIOMIC主任，DAC团队负责人）， 博士Richard Caprioli（MPI，CC团队负责人）、Alvin Powers博士（MPI，胰腺OSP团队负责人）和 Kevin Schey（MPI，Eye OSP共同团队负责人）。这四个人在严格的、 大型研究项目，他们管理研究活动，合作和数据 协同为了对HuBMAP联盟做出富有成效的贡献，拟议的范德比尔特眼和 胰腺TMC将共享和接受方案，样本和数据，以促进和统一3-D分子图谱 整个财团的建设。范德比尔特团队将跟进并参与政策的制定 和程序，包括数据/标本共享和出版。的 协调委员会和拟议中的战术管理委员会的总体使命是成功地为军事基地管理和评估中心（HuBMAP）提供帮助， 推动生物医学研究的分子人体组织图谱。